Objective To explore the effect of cryotherapy and compression system in rehabilitation treatment for reconstruction of anterior cruciate ligament.Methods One hundred and twenty patients who had been treated with reconstruction of anterior cruciate ligament were randomly divided into treatment group (60 patients,treated with cryotherapy and compression system) and control group (60 patients,treated with traditional method).All patients was treated for 3 months and followed up for 6 months.The scores of visual analogue scales(VAS),degree of swelling,Lysholm and IKDC scores were observed and compared.Results The scores of VAS in treatment group postoperative 6,24 and 48 h were significantly lower than those in control group (P ＜ 0.01).The degree of swelling in two groups postoperative 6 h,12 h,24 h,48 h,1 week,2 weeks had significant difference(P ＜ 0.05).The degree of swelling in treatment group postoperative 4 weeks,3 months and 6 months was lower than that in control group,but there was no significant difference (P ＞0.05).The scores of Lysholm and IKDC in treatment group postoperative 4 weeks were (65.2 ± 12.3),(65.3 ± 14.3) scores,in control group were (60.2 ± 12.5),(59.4 ± 13.5) scores,there was significant difference (P ＜0.05).The scores of Lysholm and IKDC in two groups postoperative 3,6 months hod no significant difference (P ＞ 0.05).Conclusion The cryotherapy and compression system in rehabilitation treatment for reconstruction of anterior cruciate ligament can improve the effect of early-term rehabilitation training,but has little impact on the long-term rehabilitation training.

Orexins are a class of important hypothalamic neuropeptides,including type A and B. Orexins are associated w ith numerous physiological functions, including sleep-aw akening, energy balance, endocrine and visceral functions, and they also have certain relations w ith the pathophysiological changes, such as drow siness and drug abuse. In recent years, the pathophysiological role and mechanism, as w el as the clinical significance of orexins in cerebrovascular diseases are causing concern. This article summarizes the roles of orexins and focuses on the roles of orexin A in cerebrovascular diseases.

Vitamin D is a group of steroid hormones.Studies in recent years have shown that vitamin D is associated with the incidence of cerebral infarction,the severity of infarction,and functional outcome.In addition to the indirect effect of vascular risk factors,vitamin D may also play the direct protective effect by inhibiting inflammation and oxidative stress after cerebral infarction.

Innate immunity plays an important role in inflammatory injury after cerebral ischemia,and inflammasome is considered to be a key factor.Inflammasome is a macromolecular protein complex,can recognize pathogen-associated molecular patterns and damage-associated molecular patterns,and mediate immune inflammatory responses.Studies have shown that cerebral ischemia can induce the acute activation of the NLRP1 and NLRP3 inflammasomes.This article reviews the structure,activation and regulation of inflammasome,and the roles of inflammasome in cerebral ischemia.

Objective:To discuss the anti-rheumatoid arthritis activity and mechanism of hospital preparation Erteng Tongbi gran-ule ( ETTB) . Methods:The collagen-induced arthritis ( CIA) animal model in DBA/1 mice was established and treated with high, medium and low dosage of ETTB. Blank control, model control and methotrexate group were also established. The influences of ETTB on BMI, arthritis index, ankle joint destruction and expression of serum cytokine TNF-α and IL-6 in CIA mice were observed. Re-sults:Compared with the control group, ETTB at high dose (6g?kg-1) could significantly decrease the arthritis index of CIA mice (P<0. 05), and the joint damage on the 14th day was also significantly improved. ELISA results showed that ETTB at high dose could significantly inhibit the secretion of cytokine TNF-αand IL-6 when compared with the model group (P<0. 01). Conclusion:Hospital preparation ETTB has anti-rheumatoid arthritis activity, and its mechanism may be related with the inhibition of cytokine secretion.

Since it has been found that autoimmune thyroid diseases (Graves' disease and moyamoya disease) may have a causal relationship mediated by immune mechanism, the relationship between thyroid autoantibodies and cerebrovascular diseases has attracted more and more attention. Recent studies have shown that thyroid antibody abnormalities can affect the occurrence and development of vascular events. Therefore, this article reviews the relationship between thyroid autoantibodies and intracranial artery stenosis and the related mechanism.

ObjectiveTo revise belief in a just world scale (BJW) established by Dalbert according with Chinese cultures and examine its reliability and validity.MethodsAt the base of studying abroad-related questionnaire and preparatory tests,a total 930 undergraduates form The East,The Middle and The West of China participant in this test respectively.ResultsThrough item analysis and explore factor analysis,the revised belief in a just world contained 13 items and 2 subscales which could explain 52.205％ of the total variances.The results of confirmatory factor analysis showed that the revised belief in a just world scales had good construct validity.The Cronbach's coefficients of the scales was 0.885,and test-retest reliabilities was 0.884.ConclusionThe revised belief in just world scales has fairly high reliability and validity.

Objective To investigate the clinical result, complication and influential factors of lyophilized and radiation-sterilized morselized allogeneic bone. Methods Between December 1995 and December 2000, 778 cases with implantation of bone allograft were performed. There were 188 females and 590 males with an average age of 37.2 years (range, 6-76 years). The lyophilized morselized allogeneic bone was processed according to American Association of Tissue Bank (AATB) standards and was sterilized by radiation. The bone allograft was rehydrated in fresh blood or in physiologic saline before implantation. The morselized allograft was used to fill defects attributable to various causes such as 84 bone tumors (10.8%), 551 fractures (70.8%), 143 joint fusions (18.4%). After implantation of the bone allograft, drainage was carried out for 2~3 days and antibiotics were used to prevent infection. The average amount of the allograft implanted was 24 g (range, 4-64 g). Results All patients were followed up clinically and radiographically. The minimum length of follow-up was 3 years with an average follow-up period of 59.7 months (range, 36-96 months), 722 allograft unions occurred at a mean of 4.5 months postoperatively (range, 3-8 months). There were 137 complications, included 44 of wound effusion (5.65%), 29 of delayed wound healing (3.72%), 2 of profuse liquid accumulation (0.26%), 43 of fracture non-union (5.52%), 4 of tumor recurrence (0.51%), 9 of fusion failure (1.15%) and 6 of fracture (0.77%). Estimated by the combined Mankin and Komender standards, 688 (88.44%) patients were satisfied with their outcomes while the other 90 (11.56%) patients were dissatisfied. Conclusion The lyophilized and radiation-sterilized morselized allograft is of good tissue compatibility and able to promote bone formation, it can be considered as a convenient, safe, and available material for bone transplantation. The important factors affecting allograft healing are the mechanical stability in the recipient region, local blood supply for the site of grafting and the surgical technology. The major complications of allograft are late infection and re-fracture.

0.05). Compared with primary trigeminal neuralgia group and normal control group,the LPs in each wave of BR were significantly prolonged in secondary trigeminal neuralgia group(all P

Objective To investigate the effects of mild hypothermia on the expression of Dickkopf-1(Dkk1)in rats'brains after focal cerebral ischemia and reperfusion and to explore the molecular mechanism of any neuroprotective effects of mild hypothermia. Methods A focal cerebral ischemia and reperfusion model was established in rats by intraluminal filament occlusion of the middle cerebral artery.The adult rats were randomly divided into four groups:a sham-operation group,a sham-operation plus mild hypothermia group,a model group,and a model plus mild hypothermia group.The expression of Dkk-1 mRNA and protein in the ischemic cortex at different phases afterreperfusion were assessed using a reverse transcription polymerase chain reaction(RT-PCR),Western blotting and immunohistochemical staining.Results There was little expression of Dkk-1 mRNA or its protein in the sham-operation group or in the sham-operation plus mild hypothermia group.Expression of Dkk-1 mRNA and its protein began to increase after 2 h of cerebral ischemia and 3 h of reperfusion,with expression peaking at the 24th h after the start of reperfusion and then decreasing markedly.But expression was still stronger than in the sham-operation group at the 72nd h.At every reperfusion time point,expression of Dkk-1 mRNA and its protein were markedly less in the model plus mild hypothermia group than in the model group. Conclusion Dkk-1 probably participates in the pathologic process of injury caused by focal cerebral ischemia and reperfusion.Inhibiting the expression of Dkk-1 after focal cerebral ischemia and reperfusion is partly responsible for the neuroprotective effects of mild hypothermia.