Objective: To ascertain the process conditions for extracting the volatile oil from kangchi Capsules. Methods: The effects of water adding amount and extraction time on the yield of volatile oil were studied. The extraction condition of percolation was established with the extract yield and extraction transfer rate of tanshinone Ⅱ A as markers and the optimum condition for reflux method also was selected with the orthogonal test. Results: The volatile oil of Rhizome Acori Graminei could be basically extracted when it was extracted for 5 hours with 12 times of water. Radix Salviae Miltiorrhizae and Radix Polygalae could be effectively extracted with the peocolation and reflux methods in 90% alcohol as a solvent. But the percolation method used less energy consumption and solvent than refluex method. So the production cost was lowered. Conclusion: The experimental results provide the basis for the ascertainment of extraction process of kangchi Capsules.

Feeding intolerance in preterm infants,which is an important issue that the neonatal pediatri-cians have to work out,leads to malnutrition of early preterm infants and growth restriction which have an impact on later behavioral and cognitive outcomes. Feeding intolerance is related to the immature of gastrointestinal function,perinatal asphyxia,infection and other diseases. Minimal enteral feeding,prokinetic agents and supple-mentation of the enteral probiotics,are used generally,but at present there is no guidelines for the prevention and treatment.

Objective To investigate the relationship between coronary artery lesions and multiple risk factors in the patients with metabolic syndrome (MS) and coronary heart disease (CHD). Methods Totally 429 patients were definitely diagnosed with CHD by coronary arteriography and their BMI, BP, FBG, TG, HDL-c as well as age, gender, smoking, TC, LDL-c, UA were recorded. All patients were divided into two groups: CHD with MS, CHD. Results BMI, BP, FBG, TG, HDL-c, TC, LDL-c and UA were significantly higher in CHD with MS group than those in CHD group (P

Objective　To investigate what effects BmKAS-1 (a polypeptide purified from the Chinese scorpion Buthus martensi Karsch ［BmK］ and named as BmK activator of skeletal-muscle ryanodine receptor) and its upstream mixture BmK1-3-2 have on Na+ channels in dorsal root ganglion (DRG) small diameter neurons. Methods　The whole-cell patch-clamp technique was used to investigate the effects of BmKAS-1 and BmK1-3-2 on Na+ current in rat small diameter DRG neurons. Results　About 50% peak Na+ current was suppressed by 10*!μg/ml of BmK1-3-2. 1.62*!μg/ml of BmKAS-1 also blocked 50% peak Na+ current, and there was an obvious dose-dependent relationship. Conclusion　Both BmK1-3-2 and BmKAS-1 have a blocking effect on Na+ channels, and this may one of the mechanisms for the analgetic effect of BmK1-3-2 and BmKAS-1.

Alzheimer′s disease (AD) is a neurological disorder of unknown etiology characterized by memory loss and severe intellectual impairment. Transcranial direct current stimulation (tDCS) acts on the brains of AD patients in a non-invasive manner by reducing neurotoxic substances, promoting synaptic plasticity, producing long-term after-effects, weakening neuroinflammation, and reducing oxidative stress in brain tissue, among other mechanisms that affect patients′ memory functions. Therefore, tDCS has become an important tool to improve the memory of AD patients. And the effect of this treatment on memory improvement is influenced by factors such as stimulation site, current level, and stimulation duration.