ObjectiveTo investigate the context-sensitive half-times of etomidate. Methods Twenty patients ( ASA Ⅰ - Ⅱ ) underwent selective thoracic operation were divided into 2 groups by random digits table with 10 cases each,the patients were allocated to receive either continuous infusion etomidate 10μg/(kg·min) for 1 h(Gl group) or continuous infusion etomidate 10 μg/(kg·min) for 2 h(G2 group) of maintenance anesthesia. The samples were collected at the following time points: 1 min before stop infusion,2,5, 10,15,20,30,40,50 and 60 min after stop infusion. The plasma concentrations of etomidate were measured by high-performance liquid chromatography and the changes of the context-sensitive half-times of etomidate were calculated. ResultsThe context-sensitive half-times of etomidate was ( 17.1 ± 13.1 )min in G1 group and (21.7 ± 15.1 ) min in G2 group. There was no significant difference between two groups (P＞0.05). ConclusionThe context-sensitive half-times of etomidate is short and its pharmacokinetic profile is suitable for continuous infusion.

Objective　To explore an objective and precise method of measuring the angles of human ears.Methods　Thirty cases (60 ears) were measured by CT.They were performed in position of Frankfort horizontal plane.Results　Auriculo-cranial is 45±14 degrees,cephaloconchal is 83±13 degrees,scaphaconchal is 92±4 degrees,and they are symmetric on both sides.The differences of the angles between men and women are not obvious,except auriculo-cranial angle.Conclusion　The measurement of human auricular angles with CT is a useful and practical method in anthropology and aesthetic medicine.

The number of IPFI has increased in recent years because of the increasing of immunocompromised hosts due to abuse of antibiotics,glucocorticoids,immunosuppressants and all kinds of invasive operations,organ transplants.The mortality of IPFI remains highly because it's difficult to early diagnosis.Histopathologic biopsy remains as the gold standard for IPFI diagnosis although limited by materials.Imaging manifestations are nonspecific but have important suggestive values to some kinds of fungus.Direct examination is quickly but it's difficult to distinguish strain.Fungal culture can guide the treatment but its positive rate is low and the distinguish for contamination,infection and colonization is hard.Serological test has high sensitivity and specificity,but it cannot distinguish strain and it can yield false positives and false negative.Molecular biology is one of rapid developing methods,but its application is limited due to lack of standardized procedures and standards to assess its results,furthermore it can yield false positives.The proper diagnosis for IPFI relies on the comprehensive assessment combing with advantages and disadvantages of various methods.

Bnip3,a kind of mitochondrion apoptosis gene,belongs to the Bcl-2 gene family and BH3-only subfamily.It is one of the downstream response factors of hypoxia inducible factor (HIF).Bnip3 can induce cell apoptosis and autophagy under the oxygen deficit condition.Many studies show that Bnip3 is closely related to the occurrence,development and treatment of tumors.Molecular targeting treatment aimed at Bnip3 combined with chemoradiotherapy has preferable application foreground in tumor therapy.

0 05); At the 7th day, T?RⅠ mRNAs expression was decreased( P

Objective To study the adverse effect of amatoxins on DNA in the histiocytes of rats and the antagonism of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA). Methods SD rats were randomly divided into three groups, the number of males and females was the same. The rats in the experimental groups were respectively treated with amatoxins(0.1 mg/kg bw, i.p.) and amatoxins added EPA, DHA (both were 10 mg/kg bw, i.p.) for 10 days. Single cell gel-electrophoresis was employed to test the damage of DNA in the histiocytes. Results In the group treated with amatoxins, DNA damage in the peripheral lymphocyte, hepatocytes, lung cells ,brain cells was more seriously compared with the control, but no significant DNA damage was seen in the group treated with amatoxins added EPA, DHA. Conclusion Amatoxins may induce DNA damage and eicosapentaenoic acid, docosahexaenoic acid have an antagonism to the adverse effect of amatoxins.

The clinical efficacy of two dosages of mifepristone plus methotrexate (MTX) in the treatment of ectopic pregnancy was compared.One hundred and fifty patients with ectopic pregnancy patients were stratified randomly into 200 mg's single oral group (n =77) and 150 mg graded oral group (n =73).The results showed that,when the Fernandez scores ≤ 12 points,the difference of treatment success rate was not statistically significant (98％ vs 100％,P ＞0.05) ; and when ＞ 12 points,two groups had statistical significance difference (10/13,3/11,P ＜ 0.05).The incidence of gastrointestinal adverse reactions was statistically significant between two groups (P ＜ 0.05).However,the number of leucopenia,the time of hCG back to normal and average length of hospital stay were not statistically different(P ＞0.05).

In addition to modulation by a variety of structurally diverse agents that act allosteri-cally via distinct binding sites on the receptor complexes , there is another outstanding characteristic of the GABAA receptors: they are modulated by multiple endogenous agents. Well known examples include Ca2+ , adenosine triphosphate (ATP) , protein kinase A (PKA), protein kinase C(PKC), ty-ros ine kinase (TK) and calmodulin-dependent protein kinase II (CaMK II ). Intracellular modulation of GABAA receptor function may have profound effects on the control of neuronal excitation.

Objective To evaluate CT in the diagnosis of small bowel obstruction in children. Methods Thirty one cases with small bowel obstruction manifestations on CT and plain radiograph were analysed. The age ranged from 9 months to 14 years, male 17 cases, female 14 cases. There were 29 acute small bowel obstructions, and 2 chronic obstruction. Seven cases had history of previous abdominal operation. Results Corred diagnosis was made in 19 cases and 29 cases respectively by plain film and CT. The accurate etiologic diagnosis could be made by CT in 18 cases, including small bowell stone 4 cases, intussusception, 5 localized infection and adhesion 6 intraluminal bowel duplication, 1 congenital umbilical hernia, congenital malrotation of the intestine 1 case.Combined with history of abdominal operation the accurate CT etiologic diagnosis increased to 25 cases.There were 4 CT false negative cases and 2 plain film false negative cases. Conclusion The CT is obviously superior to plain radiograph in detecting strangulation and gas in bowel wall,better dilineating the transitional segment of bowel stenosis thereby demonstrating the case of obstruction which is very helpful for clinical management.