Objective To observe the safety issues of antiplatelet agents in the acute-phase treatment and secondary prevention of cerebral thrombosis in patients with history of cerebral hemorrhage. Methods The 149 cerebral thrombosis patients with history of cerebral hemorrhage were assigned to the test group, while the 405 cerebral thrombosis patients without history of hemorrhage stroke were assigned to the control group. The patients in the two groups were continuously treated with antiplatelet agents during hospitalization and after discharge. Cumulative incidences of cerebral hemorrhage were observed during hospitalization and 1.5 years after discharge.Results During hospitalization, 7 patients in the test group and 16 patients in the control group were noted with cerebral hemorrhage attack (no death were recorded because of cerebral hemorrhage).And at 1.5 years after discharge, 15 patients in the test group and 36 patients in the control group were noted with cerebral hemorrhage attack (no death were recorded because of cerebral hemorrhage).Conclusions There are no increased cerebral hemorrhage risks for patients who have a history of cerebral hemorrhage to take antiplatelet agents during the acute phase and secondary prevention of cerebral thrombosis.

ObjectiveTo investigate whether brain microbleeds is associated with antiplatelet-related intracranial hemorrhage (ICH). MethodsForty-three patients with antiplatelet-related ICH treated in our hospital from Jun 2005 to Jun 2010 were investigated in this study.Age, sex and hypertension matched controls with non-antiplatelet-related ICH; and without history of ICH on antiplatelet therapy were selected. ResultsMicrobleeds was more frequent in antiplatelet users with ICH than in matched antiplatelet users without ICH(31/43(72. 1％ ) vs 12/57(21.1％ ), x2 =6. 731, P =0. 011 ) and was more frequent in IHC patients with antiplatelet treatment than those with non-antiplatelet treatment (31/43 (72. 1％ ) vs 17/48 (35.4％), P =0. 030). The frequency of lobar microbleeds(27/43, 62. 8％ ) was significant high in antiplatelet-related ICH than that in non antiplatelet-related ICH (19/48, 39. 6％, x2 =4. 019, P =0. 042). The number of microbleeds was associated with the risk of antiplate-related ICH ( OR =1.38 per additional microbleed, 95％ CI 1.07-1.71, t =0. 806, P =0. 021 ). ConclusionBrain microbleeds are associated with antiplatelet-related ICH.

Objective To approach the clinical applied value of MSCT coronary angiography in detecting coronary artery disease. Methods 150 patients underwent MSCT coronary angiography, of them, 100 patients were also examined by coronary arteriography. The ability in showing coronary arteriae with MSCT was evaluated comparatively with coronary arteriography. Results The success-ful rate in showing coronary arteriae by MSCT was 95.3%,the excellent rate of images was 82.970%. There was negative correlation between image quality and heart rate(r=0.938). And the accurate rate in evaluating the narrowing of coronary arteriae was 91.2% with MSCT. There was no significant difference in detecting the narrowing of coronary arteriae with MSCT and coronary angiography (P>0.05). Conclusion By controlling the patients' heart rate(below 70/min) and optimizing the technical methods,MACT coro-nary angiography can detect all of the 1～3 branch of coronary artery. MSCT has some particular superiority in diagnosing coronary artery disease and evaluating the effects of coronary artery bypass graft.

Flexible bronchoscopy has become an important method in diagnosis of pediatric respiratory diseases.Here,we introduced some diagnostic techniques such as bronchoalveolar lavage,protected specimen brushing and biopsy techniques including endobronchial biopsy,transbronchial lung biopsy,and transbronchial needle aspiration.Meanwhile,its role in the diagnosis of common diseases and symptoms (abnormality of airways,dyspnea,refractory wheezing,chronic cough,tuberculosis and bronchial foreign bodies)was discussed.

In this article, the manifestations of the DSA in 100 patients with primary hepatic carcinoma have been studied. According to the haculta the authors put forward a method for classification by DSA findingas of the hapatic carcinoma, It can be expressed in A B C D. A represents the site and shape of the tumor; B represents the blood supply; C represents having or not having arterial - venous fistula; D represents the condition of the portal vein. Simnltaneouly the authors pointed out its clinical significance by reflecting the whole changes of the fumor in morpholygy and hemodynanics useful to plan an interventioanl therapy, and to assess the prognosis.

The comprehension of the current status and summary of the advantages vs disadvantages of different interventional methods for the treatment of tumor were concluded in the article.Although all these methods have improved the efficiency of tumor therapy,they are still having a lot of space for further development.The author gives a new concept of the molecular interventional therapy of tumor.

Dishevelled (Dvl) is a kind of protein widely existing in human tissue, containing three structural domains:Dishevelled and Axin (DIX);postsynaptic density protein-95, disc large tumour suppressor, zonula occludens-1 (PDZ);and Dishevelled, Egl-10 and pleck-strin (DEP). Dvl participates in the Wnt signaling through different structure domains to play a role in nervous system development and neu-rogenesis after nerve injury.

Objective To observe the therapeutic efficacy and evaluate the health economics of early rehabilitation intervention applied to patients with cerebral hemorrhage in stroke unit. Methods A total of 131 cerebral hemorrhage patients were randomly assigned to the stroke unit group (n=62) and the control group (n=69). The patients in the stroke unit group received rehabilitation training at a very early stage, while there were no rehabilitation training program and no professional treatment team for patients in the control group. Results of the national institute health stroke scale (NIHSS), activities of daily living (ADL) Barthel index were compared between the two groups. Infection rate, mortality, cost of hospitalization and length of stay were also compared. Results There were better therapeutic effects as revealed by NIHSS (4.3±3.5 vs. 7. 9±5.0, t=-3. 211, P<0.05), ADL Barthel index score (85.9±29.6 vs. 67.1±37.1, t=3.194, P<0.05), lower incidence of infection in lung (8.06% vs. 15.94%, χ~2 =3.901, P<0.05) and in urinary tract (6.45% vs. 11.59%, χ~2 =4. 138, P<0. 05), lower mortality (4.84% vs. 7.25%, χ~2=4. 351, P< 0.05), lower cost of hospitalization[￥ (17506. 90±954.10 ) vs. ￥(21096.49±923.46), t=-20. 786, P<0.01)] and shorter length of stay[(20. 47±7. 03)d vs. (31. 42±8.14)d, t=-8.196, P< 0.01)] in the stroke unit group compared to the control group. Conclusions Early rehabilitation intervention by stroke unit is advantageous to patients with cerebral hemorrhage.

Objective To study the clinical effect and the range of indications of oxygen-ozone treatment for lumber disc herniation. Methods 6～15 ml of oxygen-ozone(35～45 ?g/ml) were injected percutaneously into lumbar disc.In case of multiple disc herniations,the proceduce could be taken with two discs for once. Results 323 patients with 433 discs were treated by oxygen-ozone injection procedure.Total effective rate was 77.7%. Conclusions The treatment of lumber disc herniation by oxygen-ozone injection is simple,safe and effective with mild trauma.Oxygen-ozone not only can oxidize the proteoglycan in the nucleus leading to the contraction of nucleus,but also provide anti-inflammation effect with pain relief and without complication yet.

Genome ; Humans ; Precision Medicine