Objective To observe the efficacy of pioglitazone combined with repaglinide in the treatment of external insulin antibody (IAb)-positive patients with type 2 diabetic nephropathy.Methods 44 cases with IAb positive diabetes nephropathy were divided into the treatment group (22 cases) and control group (22 cases).The treatment group moved gradually insulin to pioglitazone 15 mg once daily add repaglinide 1 mg three times daily oral and gradually adjustment dose.The control group continued to use insulin treatment,a total of 12 weeks.Before and after treatment,blood sugar,blood fat,glycosylated hemoglobin,etc were detected.Results Mter treatment,the blood glucose,glycosylated hemoglobin,urine albumin and urine creatinine ratio of the treatment group were significantly decreased (all P ＜ 0.01),the above indicators had statistically significant differences compared with the control group at the same period (P ＜ 0.05).Conclusion Pioglitazone combined with repaglinide is an effective method for treatment of IAb positive type 2 diabetic nephropathy.

Objective To observe curative effect of acupuncture treating children acute upper respiratory infections (AURI).Methods According to random digits table,150 children from clinic emergency department were averagely bring into a acupuncture treatment group and a western medicine treatment group.Patients in the acupuncture treatment group received the treatments of acupunctureing one side of “SiGuan”points,bloodletting in apex satyri,and reducing temperature with tepid sponge bath; while patients in the western medicine treatment group received the treatments of taking ibuprofen suspension,using external pyretolysis patches on forehead,and reducing temperature with an alcohol sponge bath.After the treatment,the near future therapeutic effects:the time of pyretolysis,fevering again in 24 hours and convulsion time,and the prostecdtive efficacy:the time of cough continuing,AURI happening again in 3 months and recovery time of appetite were both observed.Results The time of pyretolysis,fevering again in 24 hours,convulsion time,the time of cough continuing,recovery time of appetite and AURI happening again in 3 months of acupuncture treatment group was(15.6±5.8) minutes,(12.7±3.3) hours,(0.6±0.1) times,(2.3±1.8) days,(2.4±1.6)days,and (35.2±3.9) days respectively; and the western medicine treatment group was (25.5±7.3) minutes,(8.6±4.1) hours,(2.1±0.5) times (6.2±2.4) days,(3.8±1.5) days,and (18.4±5.2) days respectively.Comparing between the two groups,P＜0.05.Conclusion Acupuncture can significantly decrease the time of pyretolysis,cough continuing,recovery time of appetite and convulsion time,and significantly increase the time of fevering again in 24 hours and AURI happening again in 3 months in patients with AURI.

Objective To analyse the clinical situations and other factors that influence the PetCO2 monito-ring. The analysis can improve the nursing care for mechanical ventilated patients. Methods To retrospectively ana-lyze 212 PetCO2 monitoring ntanbers and capnograms in 108 mechanical ventilated patients. Results PetCO2 abnor-malities rate was 13.4%; leakage in the ventilator system was 30.4%; endotracheal tube malposition 6.8%; endo-tracheal tube baloon leakage 11.3%; secreations 22.4%; hyperventilation 12.5%; hypopeffusion 7.6%; hypoper-fusion of the lung 5.8%; mechanical malfunctioning 3.2%. Conclusions Continue monitoring of PetCO2 and cap-nogram along with hemodynamic monitoring in mechanical ventilated patients can timely find patients' problems and promptly use appropriate interventions. The understanding of these monitoring systems can improve the quality of the nursing care for the critically ill patients.

ObjectiveTo investigate the effect of nursing intervention on sleep quality of patients after cardiac intervention. Methods140 patients undergoing cardiac interventional surgery in our hospital from January 2010 to January 2011 were chosen as the research object.They were divided into the observation group and the control group in accordance with the principle of randomization with 70 cases in each group.The control group was treated with conventional methods of nursing care of cardiology.The observation group was given with sleep- related nursing interventions on the basis of the routine care.The sleep quality score (PSQI)24 h and 1 week,2 weeks postoperation and treatment compliance 2 weeks postoperation were compared between the two groups. ResultsThe study showed that the PSQI score 24h postoperation showed no significant difference,but 1 week and 2 weeks after the operation,the score of the observation group was significantly lower than the control group.The full compliance rate in the observation group was significantly higher than the control group.The non-full compliance rate was significantly lower than the control group,the differences were statistically significantConclusionsNursing intervention can improve treatment compliance of patients,improve sleep quality of patients after cardiac intervention.It is conducive to the rehabilitation of patients and is worthy of clinical application.

Objective To prospectively observe the changes of amplitude-integrated electroencephalogram(aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE).Methods Thirty-five HIE neonates with gestational age of 37 ～ 41 weeks were chosen as HIE group,and all of them were hospitalized in neonatal intensive care unit of Bethune International Peace Hospital from Aug 2011 to Jan 2012.At the same time,40 healthy term neonates were chosen as control group.aEEG monitoring was done within 24 ～ 48 hours after birth with cerebral function monitor (CF3000) and each recording last at least 8 hours.The continuity,sleep-wake cycle,voltage of every aEEG tracing were analyzed.Results (1) The maximal voltage of aEEG tracing in control group was 30 μV,while that in HIE group was 16 μV.The minimal voltage of aEEG tracing in control group was 13 μV,while that in HIE group was 7 μV.The aEEG tracing amplitude both in highest and lowest in HIE group were significantly lower than those in the control group.There were significant differences between them (P ＜ 0.05).(2) There was significant difference of sleep-wake cycling between HIE group and control group[20％ (7/35) vs 100％ (40/40),x2 =51.064,P ＜ 0.05].While there was also significant difference of the continuity of the amplitude between HIE group and control group[31％ (11/35)vs 100％ (40/40),x2 =40.336,P ＜0.05].Conclusion aEEG has some specific changes in neonates with HIE,possiblility it can be used for earlier predicting the occurrence of brain damage after asphyxia and provides good evidence for the early diagnosis and treatment of HIE.

Child ; Humans ; Mitochondrial Diseases ; diagnosis ; Pediatrics

Using morphometry and impregnation technique of lanthanum nitrate,acomparative investigation on the epidermis structure of high and low electricresistance skin points was carried out in mice and rabbits at both light and electronmicroscope level,with special emphasis on the structure of gap junctions in epidermis.It was observed that the frequency of gap junctions in low resistance points wassignificantly higher,and their diameter was larger than that in high resistancepoints,while no difference was found in other structure parameters examinedbetween the two types of skin points.It is assumed that the gap junctions may bethe structure basis for the difference in skin electric resistance.

0.05) The above amount was enough to maintain the subjects two weeks in good vitamin C nutrition as judged by steady plasma ascorbic acid content of about 1 mg%. At the end of maintenance period, 400mg of ascorbic acid was administered. The urinary excretion of ascorbic acid in 24 hours was about 30% of the test dose.This method is reliable but not suitable for large scale analysis as it involves daily urine collection and analysis.The urinary excretion of ascorbic acid decreased during menstrual period in women subjects.

Objective To investigate the effects of functional electrical stimulation (FES) on motor function and on the expression, proliferation, migration and differentiation of endogenous neural stem cells in the subventricular zone (SVZ) after cerebral ischemia.Methods Middle cerebral artery occlusion (MCAO) was used to induce a model of cerebral ischemia in 108 rats using the modified Zea-Longa method of intraluminal filament occlusion.They were then randomly divided into an FES group, a placebo stimulation group and a control group with 36 cases in each.Superficial FES electrodes were pasted on the paralyzed forelimbs of the rats in the first two groups, though FES treatment was administered only to the FES group beginning on the 3rd day after the MCAO operation.The stimulation was designed to produce extension of the wrist and digits of the paralyzed forelimb.Before, and after 1,3, 7 and 14 days of the treatment, the neurological deficit was evaluated using modified neurological severity scoring (mNSS).BrdU +/GFAP+, BrdU+/DCX+ and BrdU+/NeuN + cells in the SVZ were detected using immunofluorescence technique.Results After 7 and 14 days of treatment, the average motor function of the rats in the FES group had improved significantly when compared with the averages of the other two groups.Compared with the other two groups, the average number of BrdU +/GFAP+ positive cells in the ischemic SVZ was also significantly greater in the FES group after 7 and 14 days of treatment.After 14 days, BrdU +/Dcx + positive cells in the FES group had also increased significantly more,but only a few BrdU +/NeuN + cells had appeared in any of the three groups.Conclusion FES can improve motor function after cerebral ischemia, and promote proliferation and differentiation of neural stem cells in the SVZ.

Objective To translate the Personal Diabetes Questionnaire(PDQ),and test the relia bility and validity of the Chinese version of PDQ.Methods Through forward translation,back translation,cultural adjustment,etc.,the Personal Diabetes Questionnaire (PDQ) was introduced to localize it.60 eligible patients with diabetes were selected in a tertiary hospital to make a preliminary investigation.The results were statistically analyzed in order to assess the reliability and validity of the Chinese version of PDQ.Results The Chinese version of PDQ had good reliability,whose total internal consistency coefficient was 0.831 and test-retest reliability was 0.801.The questionnaire has good validity.Total Content Validity Index was 0.938.I-CVI was between 0.800 and 1.000.The questionnaire's dimensions had good parallel validity with glycosylated hemoglobin (HbAlc) and body mass index (BMI).Conclusions The Chinese Version of the personal diabetes questionnaire has good reliability and validity,which can be widely used as the evaluation tool of diabetes self-management education.