Epstein-Barr virus (EBV) related post-transplant lymphoproliferative diseases (EBV-PTLD) is a rare and deadly complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical manifestations often show the unexplained fever, swollen lymph nodes, hepatosplenomegaly, pharyngitis, and central nervous system symptoms, with rapid disease progression and high fatality rate. As allo-HSCT for treatment of complex and refractory hemopathy has made a great progress, the prevention of graft versus host disease (GVHD) requires more application of immune inhibitors, resulting in an increasing incidence rate of PTLD. In addition to conventional treatments, such as antiviral therapy, reduction of immune suppression , local surgery and traditional chemotherapy, monoclonal antibodies and adoptive immunotherapy with T-cells for treatment of PTLD have brought a profound influence. This paper reviews the latest progress of treatment of EBV-PTLD.

Objective:To optimize the storage placement of drug in automatic dispensing machine so as to increase the dispensing speed and work efficiency.Methods: The drugs were dispensed on the up and down side of the center of axle wire from high to low according to the dispensed frequency. The application regularity of various drugs was analyzed by using a number of prescription information and the relevant drugs were stored in nearest tank aroundthe drug outlet as the principle of minimum time algorithm. Through optimizing the storage placement of automatic dispensing machine and applying average dispensing time as evaluation index, the change of average dispensing time between before and after 3 months of the optimization of storage placement was analyzed.Results: After the storage placement was optimized, average dispensing time was shortened 2.0s. And the difference of the time between before and after optimization was statistically significant (t=11.92,P<0.05). Conclusion: Through applying minimum time algorithm, the optimized storage placement of automatic dispensing machine shortens the dispensing time of prescription and increases work efficiency.

OBJECTIVE: To properly evaluate the conditions of clinical practice of quinolone antibacterial agents. To provide data for clinical medicine and to guide rational drug use. METHODS: 237 cases with adverse reactions induced by quinolone antibacterial agents reported in demestic literatures issued from 1985 to 1997 were collected and statistically ana- lyzed. RESULTS: The general rule and characteristics of occurrence of adverse reactions resulted from quinolones have been summarized. CONCLUSION: The indications for clinical use of quinolones should be handled strictly, especially in children, so as to avoid the abuse of drug.

Objective To investigate the effect and safety of early electric bronchoscope on patients with nonresponding pneumonia. Method Seventy non responding pneumonia patients were selected from our hospital , who received treatments from January 2015 to April 2016.According to the random table ,patients were randomly divided into the observation group(34 cases)and the control group(36 cases). According to the experience and sputum culture results,patients in the control group were given the conventional therapy,and patients in the observation group were given bronchoscope and transbronchil lung biopsy(TBLB). The effect of bronchoscopy,the treatment curative effect,duration of fever,the period of the elevated CRP dropped to baseline,the length of hospital stay and medical costs were compared between the two groups. Results The diagnostic rate of bronchoscopy and the positive rate of airway suction bacterial culture in the observation group were similar with those in the control group,with no significant differences. The positive rate of airway suction bacterial culture was significantly higher than that of sputum culture in the observation group. The positive rate of airway suction bacterial culture was higher than that of sputum culture in the control group ,but with no significant difference.The total effective rate in the observation group(87.1%)was significantly higher than that in the control group(58.8%). The duration of fever and the time of the elevated CRP dropped to baseline in the observation group were significantly shorter than those in the control group. The hospital stay and hospital costs in the observation group were also significantly lower than those in the control group. Conclusion Early bronchoscopy can obtain diagnosis evidence of etiology and histology and improve the diagnostic rate,meanwhile,it also has a therapeutic effect.It can improve the clinical treatment effect and shorten the healing time and the cost of hospitalization. In addition , early electronic bronchoscopy has fewer adverse reactions and it may play an important role in diagnosis and treatment on nonresponding pneumonia patients.

Hydrolysate of Meretrix meretrix soft tissue (HMST ) (20, 10g/kg ,po.for 14d ) could markedly inhibit the increase of serum total cholesterol(TC)and triglyceride(TG),enhance the content of high density lipoprotein cholesterol(HLD-C) ;reduced cholesterol(Ch)of the liver(for 28d)in hyperlipimic quail ;and it could also reduce whole blood viscosity in normal and hyperlipemic quail (for 21d).In addition.it could suppress the platelet aggregation induced by ADP in rabbits in vitro. The results show that HMST obviously decreased blood lipid and whole blood viscosity .inhibited platelet aggregation.

Eighty-eight patients with obstructive sleep apnea hyperpnoea syndrome (OSHAS) were assigned to the mild (n =21 ), moderate (n =30), or severe group (n =37) according to apnea-hypopnea index( AHI ). Twenty-five healthy individuals were selected as normal controls. Color Doppler ultrasonography was used to measure the intimae-media thickness of the carotid coteries and the occurrence of sclerosis plagues. Our data found that increased severity of OSHAS led to the elevated intimae-media thickness of the carotid coteries and more sclerosis plagues, which suggests OSHAS may influence the development of the carotid artery arthrosclerosis.

Objective To investigate clinical value of Tei index used for monitoring right ventricular (RV) function in pregnant women complicating cardiac disease accompanying pulmonary hypertension(PH) and the influence on left ventricular(LV) function due to overload pressure of RV. Methods Fifty-eight pregnant women complicating cardiac disease (including 32 cases with congenital heart disease,14 cases with rheumatic heart disease and 8 cases with arrhythmia)were enrolled in this study, among 26 cases coexisted with pulmonary hypertension. According to the pressure of PH, those patients were divided into three groups:11 cases in mild group[30-49 mm Hg (1 mm Hg=0.133 kPa)],9 cases in moderate group (50-79 mm Hg)and 6 cases in severe group (≥80 mm Hg). In the mean time, 15 healthy pregnant women were matched as control. Tei index were measured for LV and RV respectively. Results (1) The isovolumetric relaxation time [IRT,(93±52) ms] and isovolumetric contraction time [ICT,(66±41) ms] of RV in PH group were significantly higher than normal controls [(39±19) ms in IRT and (38±20) ms in ICT] and the other patients without PH group[(59±12) ms in IRT and (43±19)ms in ICT, P<0.01, P<0.05;P<0.05,P<0.05]; however, ejection time (ET) was(239±46) ms significantly shortened in PH group (P<0.05,P<0.01) when compared with (250±41) ms in patients without PH and (299±38) ms in normal controls. Tei index in PH group were 0.72±0.49, which were significantly higher than 0.38±0.12 in normal controls and 0.43±0.16 in patients without PH (P<0.01,P<0.05). (2) The IRT[(99±27)ms] and ICT[(71±40) ms] of LV in PH group were significantly higher than in normal controls [(88±20) ms,(50±24)ms] (P<0.01,P<0.01). ET of LV in PH group [(202±26)ms] were significantly shortened that (290±21)ms in normal controls and (220±36)ms in patients without PH (P<0.01,P<0.05). Tei index of LV in PH group were significantly higher than 0.43±0.15 in normal controls and 0.58±0.21 in patients without PH (P<0.01,P<0.05). (3) Positive correlation between Tei index of RV and pressure of pumonaroy artery were observed (r=0.84, P<0.01). (4) Tei index of RV in severe PH were significantly higher than mild PH (0.75±0.43 vs. 0.68±0.35, P<0.01) and moderate PH (0.75±0.43 vs. 0.71±0.14, P<0.05). Conclusions (1)The Tei index is a novel efficient Doppler index in assessing RV function of pregnant women complicating cardiac disease accompanying PH. And the fluctuation of Tei index might reflect seriousness of the disease. (2) The overload pressure of RV pressure due to PH has significant influence on LV function.

This paper tried to describe the hospital labor union how to play an important role on hospital's development,as well as adopt its own characteristic and advantages in order to improve hospital's medical treament and scientific research.

Objective To analyse the relationship between the left ventricular(LV)structure,function and changes of concentration of serum matrix metalloproteinase-1(MMP-1),tissue inhibitor of matrix metalloproteinase-1(TIMP-1),and evaluate the value of the change of serum MMP-1 and serum TIMP-1 in ventrieular remodeling of pregnant women complicating cardiac disease.Methods Fifty-eight cases of pregnant women with cardiac disease divided into three groups[group A had 17 cases who had clinical manifestations and no left ventricular hypertrophy(LVH)],group B had 15 cases who had clinical manifestations and LVH but no palmonaly hypertension(PH),group C had 26 cases who had clinical manifestations,LVH and PH which divided into three groups again:11 cases of slight group[PH from 30-49 mm Hg(1 mm Hg=0.133 kPa)],9 cases of moderate group(PH from 50-79 mm Hg)and 6 cases of severe group(PH≥80 mm Hg).Fifteen healthy pregnant women acted as control group.The left ventricular structure and function[(left ventrieular nlasS index(LVMI),left ventricular end-diastolic diameter(INEDd),Ejection fraction(EF),E peak(E),A peak(A)and E/A],pulmonary pressure and plasma MMP-1,TIMP-1 values were determined in the third trimester of pregnancy.Results(1)LVMI (148±7)g/m~2 and LVEDd(58.9±3.5)mm in group C increased significantly(totally P＜0.01),EF (51.0±4.4)% decreased significantly(P＜0.01),E(50±10)cm/s decreased significantly(P＜0.01),A(81±13)cm/s increased(P＜0.05)and E/A(0.6±0.3)decreased significantly(P＜0.01)compared with normal subjects,group A and group B.(2)LVMI(150±7)g/m~2,LVEDd(69.7±3.4)mm in severe pulmonary hypertension group increased significantly(P＜0.01),EF(45.6±2.6)% decreased significantly(P＜0.01),E(44±9)cm/s decreased(P＜0.05),A(86±8)cm/s increased(P＜0.05)and E/A(0.52±0.17)decreased significantly(P＜0.01)compared with slight and moderate pulmonary hypertension group.(3)Plasma MMP-1(41±10)μg/L and TIMP-1(393±37)μg/L values in group C increased significantly compared with normal subjects,group A and group B(P＜0.01).(4)Plasma MMP-1(42±7)μg/L and TIMP-1(411±31)μg/L values of severe pulmonary hypertension group increased significantly compared with slight pulmonary hypertension group(P＜0.05,P＜0.01).(5)The correlation analysis indicated that:There was positive correlation between the serum concentration of MMP-1 and TIMP-1(r=0.587.P＜0.01).The serum concentration of MMP-1 was positively correlated with LVMI and LVEDd significantly(r=0.782,P＜0.001;r=0.648,P＜0.01)and was negatively correlated with EF significantly(r:-0.587,P＜0.01).(6)Plasma MMP-1 values＞50μg/L and plasma TIMP-1 values ＞450μg/L in 3 cardiac disease failure cases.Conclusions (1)The ventricular remodeling can be found in the third trimester of pregnancy of women complicating cardiac disease,and the more serious the left ventricular hypertrophy and PH,the more obvious the ventricular remodeling.(2)The changes in the plasma MMP-1/TIMP-1 values and MMP-1/TIMP-1 balance may play an important role in the left ventrieular structural.functional,and clinical manifestations of pregnant women complicating cardiac disease.(3)An increased MMP-1 and TIMP-1 level maybe can predict the presence of cardiac disease failure.

asty without increasing morbidity, especially for slim patients or patients with a large renal pelvis.