Objective To evaluate the clinical efficacy of intraarterial infusion chemotherapy in patients with advanced and/or recurrent breast cancer. Methods From February 2000 to March 2003, 18 patients with advanced and/or recurrent breast cancer were treated with interaarterial chemotherapy (IAC). The Seldinger's technique was used in all patients. IAC was administered for 2-3 courses every 3-4 weeks for each patient. Results The proceduce was successfully performed in all 18 patients including one with a complete response, 12 of a partial response, none in 3, and with progression in 2. The overall response rate was 72.2%. The frequent adverse effects were fever, leukopenia, nausea, and vomiting but no severe complication occurred. Conclusion Intraarterial infusion chemotherapy is a safe, simple, complication-free and effective in the patients with advanced and/or recurrent breast cancer.

Objective: To observe the effects of Chinese nutgalls ex tr acts on the secretion of IL-6 from monocytes induced by lipopolysaccharide (LPS ) of Porphyromonas gingivalis (Pg). Methods:Monocytes ob tained by separating human blood cells were stimulated with LPS of Pg at 25 ?g/ml, radioimmunoassay (RIA) was used to examine the effect of Chinese nutgal ls extracts at the concentrations of 6.25-100 ?g/ml on the secretion of IL-6 in the supernatant of the cell culture. Results:Chinese nutgalls extracts at the concentrations(?g/ml) of 6.25,12.50, 25.00 ,50.00 and 100.00 inhibited IL-6 secretion from monocytes by(%) 34.6,46.4,48.5,52.7 and 54.9 res pectively.Conclusions:Extracts from Chinese nutgalls may inhibit the secretion of IL-6 from monocyte induced by LPS of Pg in a dose-depend ent manner.

This study was conducted to assess the diagnostic value of serum CA19 9 in patients with pancreatic cancer. Seven hundred and seventy eight patients with the diagnosis of pancreatic cancer were involved in the study, and every patient had serum CA19 9 determined. The descriptive statistics and correlation analysis were used to evaluate the serum CA19 9 as an index in patients with pancreatic cancer. Results showed that 80 33% patients had the serum CA19 9 value higher than 37U/ml. Further more, a positive correlation was found between the serum CA19 9 and the TNM status of pancreatic cancer( r =0 513, P

Objective To investigate the effect of HPA gene polymorphism and its alleles on platelet transfusion.Methods From January 2015 to January 2017,50 patients suffered from Platelet transfusion refractoriness were collected as an observation group while 50 patients without Platelet transfusion refractoriness were collected as a control group.The HPA gene polymorphism of the both groups were compared.Results When compared with the control group,the HPA type coincidence rate of Donor and recipient in the observation group decreased significantly (4.00％ vs.82.00％,P =0.000).And patients in the observation group got decreased levels of percent platelet recovery and platelet corrected growth index.(HPA16,9,15) were common in both groups.However,aa,ab and bb of the HPA-2 allele got 37,8 and 5 cases in the observation group,while there were 48,2 and 0 cases in the control group (P=0.007).And aa,ab and bb of the HPA-3 allele got 33,9 and 8 cases in the observation group,while there were 46,3 and 1 cases in the control group (P =0.005).Moreover,aa,ab and bb of the HPA-15 allele got 35,8 and 7 cases in the observation group,while there were 47,2 and 1 cases in the control group (P =0.007).Homozygous aa were the most common gene type in the donors of the both groups,and the difference was no statistically significant (P＞0.05).As aa,ab and bb of the HPA-2,3 change,the percent platelet recovery and platelet corrected growth index both decreased (P＜0.05).Conclusion Platelet transfusion refractoriness is related to HPA gene polymorphism,and allele b may be the cause of platelet transfusion refractoriness.

Objective To establish a method for accurate typing of ABO in blood donors and patients with difficult blood types,and to provide clinical reference for safe blood transfusion,organ transplantation,and bone marrow matching.Methods The results of serological and genotyping of 178 volunteers from four ethnic groups in China were analyzed statistically,and the blood type difference coincidence test was carried out.Results The difference of blood type difference between the four nationalities was checked (x2 =24.5,P＞0.05).The results showed that there was no difference in blood group distribution between the four nationalities.Conclusion Serological results of 178 volunteers from four ethnic groups in China are consistent with the results of molecular biology,and there is no difference in blood type distribution.

OBJECTIVE:To investigate the effects of tiotropium bromide assisted with bronchoalveolar lavage (BAL) on short-term efficacy,quality of life and re-hospitalization rate of patients with bronchiectasis complicated with lung infection. METH-ODS:A total of 140 patients with bronchiectasis complicated with lung infection selected from our hospital during Oct. 2013-Dec. 2015 were divided into control group and observation group by lottery,with 70 cases in each group. Based on intervention therapy, control group received BAL. Observation group was additionally given Tiotropium bromide powder inhalation 18 μg ,once a day before going to bed,on the basis of control group. Both groups were treated for 4 weeks. Clinical efficacy was compared between 2 group;pulmonary ventilation function indexes,blood gas analysis indexes,BODE index scores and QLI scores before and after treatment,re-hospitalization rate and the occurrence of ADR were also compared between 2 groups. RESULTS:The total response rate of observation group was 91.43%,which was significantly higher than that of control group(78.57%),with statistical signif-icance (P<0.05). Before treatment,there was no statistical significance in pulmonary ventilation function indexes,blood gas analysis indexes,BOED index scores or QLI scores between 2 groups(P>0.05). After treatment,FVC,FEV1,FEV1%,p(O2) and QLI score of 2 groups were increased significantly,while p(CO2)and BODE index scores were decreased significantly,com-pared to before treatment;all indexes of the observation group was significantly better than the control group,with statistical sig-nificance (P<0.05). The re-hospitalization rate of observation group 3,6 months after treatment was significantly lower thanthat of control group,with statistical significance(P<0.05). No ADR was found in 2 groups. CONCLUSIONS:For patients with bronchiectasis complicated with lung infection,tiotropium bromide assisted with BAL can effectively relieve the clinical symp-toms and signs,improve lung ventilation function and the quality of daily life and can be helpful to reduce the risk of re-hospital-ization with good safety.

Objective To analyze the anti hypertensive drugs use of clinical characteristics of obstructive sleep apnea hypopnea syndrome(OSAHS) patients complicated with hypertension.Methods 233 obstructive sleep apnea hypopnea syndrome patients complicated with hypertension were enrolled,and they were theated with three different therapy methods.After the treatment,the situations of kind,effect and combined use of oral antihypertensive drugs were statistically analyzed.Results The most frequently used drugs were calcium channel blocker (CCB),especially nifedipine sustained-release tablets [75.5％ (176/233)];the combined prescription was 63.9％ (149/233) of all prescriptions,but the data reduced to 57.1％ (133/233) after OSAHS therapy.Conclusion There is a good condition regarding using oral antihypertensive drugs in Weihai.However,some antihypertensive drugs are used irrationally.

Background and purpose:Hyperthermia could directly kill cancer cells or induce apoptosis,it has also been proved to improve immunity of patients.In this study,we evaluated the efficacy and side effects of hyperthermia combined with transcatheter arterial infusion chemotherapy in the treatment of intermediate and advanced non-small cell lung cancer(NSCLC).Methods:Forty patients with intermediate and advanced non-small cell lung cancer were randomly divided into two groups,with 20 each.Group A was treated with transcatheter arterial infusion chemotherapy in combination with hyperthermia,Group B was treated with interventional arterial infusion chemotherapy alone.Treatment response in both groups were evaluated as well as side effects after one or two cycles.Results:As to Group A,Karnofsky score had been improved in 16 cases,accounting for 80%(16/20);compared with 50%(10/20)in the Group B,there was significant difference(P

Objective To assess the curative effect of different therapeutic regimen in perimenopausal and postmenopausal pa-tients with depressive disorder ,in order to guide clinical work .Methods Relevant literatures were collect by retrieving a number of online database ,,screen documents independent ,the randomized controlled trial(RCT) and cohort study were included ,and carried on the quality evaluation and data extractione ,then completed the Meta analysis .Results 19 papers were inclouded (2 312 cases) , including 10 RCT papers and 9 cohort papers .There was no statistically significant difference for cure rate (RR=1 .15 ,P=0 .07) , the difference of effective rate had statistically significant (RR=1 .17 ,P=0 .005) .Hormone in combination with antidepressants compared with hormone replacement therapy :the difference of cure ratio (RR=1 .73 ,P=0 .003) and effective rate (RR=1 .52 , P<0 .01) all had statistically significant .The difference of effective rate between antidepressants and hormone replacement therapy had statistically significant (RR=1 .37 ,P=0 .003) .Hormone replacement therapy compared with placebo :the difference of cure rate had statistically significant(RR=2 .17 ,P=0 .03) ,the difference of effective rate had no statistically significant (RR= 0 .78 ,P=0 .15) .Conclusion Although the hormone replacement therapy has a positive effect on the mood ,it′s promoting effect on the anti-depressant of perimenopausal and postmenopausal women is uncertain .

Objective To investigate the current status of iodine deficiency disorders in Lianyungang,Jiangsu Province,and to evaluate the effectiveness of prevention and control measures.Methods Using population probability proportional to size sampling method (PPS),in Lianyungang City,30 townships (towns) were selected,one primary school was selected in each township (town),fifty 8-10 years old students (half male and half female,uniformly distributed in age groups) were selected in each school,and goiter was examined; one random urine sample was collected to survey the urinary iodine content; household salt sample was collected to survey the salt iodine content.At the same time,30 students from Grade 5 in each school were selected,and health education questionnaire survey was conducted.In the village where the primary school located,5 housewives were selected and a questionnaire survey was conducted; salt samples were collected and salt iodine level was tested by semi quantitative detection on site; 2-5 drinking water samples were collected and the water iodine level was determined in the village.One random urine sample from twenty pregnant women and 10 lactating women in the township (town)was selected and urinary iodine was determined.The goiter was examined by palpation; urinary iodine was detected by arsenic cerium catalytic spectrophotometry (WS/T 107-2006); salt iodine was detected by direct titration,Sichuan salt and other fortified edible salt were tested by arbitration law (GB/T 13025.7-2012); water iodine was detected by the method suitable for iodine deficiency and high iodine areas (recommended method of reference laboratory of national iodine deficiency disorders).Results One thousand and five hundred children aged 8-10 years old were examined by palpation,18 children had goiter,and the goiter rate was 1.20％ (18/1 500).One thousand and five hundred urine samples of children aged 8-10 years old were tested,and the median of urinary iodine was 239.62 μg/L.A total of 1 500 salt samples were tested; the coverage rate of iodized salt was 96.73％ (1 451/1 500); the rate of qualified iodized salt was 93.53％ (1 403/1 500); and the non-iodized salt rate was 3.27％ (49/1 500).The number of question of the questionnaire survey of health education about iodine deficiency disorders among students and housewives was 2 697,450; the number of correct answer was 2 542,410; the pass rates were 94.25％ and 91.11％,respectively.Sixty-six drinking water samples were collected,water iodine median was 13.5 μg/L.Six hundred and one,two hundred and ninety-eight urine samples of pregnant women and lactating women were monitored,and the median of urinary iodine was 176.12 and 150.03 μg/L,respectively.Conclusion The status of iodine nutrition among residents in Lianyungang City has improved,the control effect of iodine deficiency disorders is significant,and the achievements are stable.