Objective To explore the changes of CX3CR1 expressions in monocytes from the patients with different types of coronary heart diseases (CHD). Methods The expressions of CX3CR1 in monocytes were measured by direct immunofluorescence associated with flow cytometry (FCM) in 54 patients with stable angina pectoris (SAP) confirmed by coronary arteriography, 61 patients with acute coronary syndrome (ACS), 20 normal individuals and 24 patients with chest pain syndrome (CPS). Gensini score system was utilized to quantitatively assess the coronary lesion in CHD patients. Finally, the correlation of CX3CR1 levels and Gensini scores was analyzed. Results CX3CR1 expressions in monocytes from the CHD patients were markedly higher than those in normal individuals (P

Objective To observe the changes of plasma urotensinⅡ(UⅡ)、PAMP(proadrenomedullin N-terminal peptide)and ANP(atrial natriuretic peptide)levels in patients with congestive heart failure (CHF) and to illustrate clinical significance of these changes.Methods 52 patients with CHF and 20 age and gender-matched control subjects were studied.Plasma UⅡ.PAMP and ANP levels of 52 patients with CHF and 20 control subjects were measured by radioimmunoassay.Heart function of all study subjects were mensurated by ultrasound cardiography.Results The plasma UⅡ levels were significantly lower in patients with CHF than that in control subjects [(1.48?1.05) vs (4.28?1.21) pg?mL -1,P

Objective To investigate the effect of HPA gene polymorphism and its alleles on platelet transfusion.Methods From January 2015 to January 2017,50 patients suffered from Platelet transfusion refractoriness were collected as an observation group while 50 patients without Platelet transfusion refractoriness were collected as a control group.The HPA gene polymorphism of the both groups were compared.Results When compared with the control group,the HPA type coincidence rate of Donor and recipient in the observation group decreased significantly (4.00％ vs.82.00％,P =0.000).And patients in the observation group got decreased levels of percent platelet recovery and platelet corrected growth index.(HPA16,9,15) were common in both groups.However,aa,ab and bb of the HPA-2 allele got 37,8 and 5 cases in the observation group,while there were 48,2 and 0 cases in the control group (P=0.007).And aa,ab and bb of the HPA-3 allele got 33,9 and 8 cases in the observation group,while there were 46,3 and 1 cases in the control group (P =0.005).Moreover,aa,ab and bb of the HPA-15 allele got 35,8 and 7 cases in the observation group,while there were 47,2 and 1 cases in the control group (P =0.007).Homozygous aa were the most common gene type in the donors of the both groups,and the difference was no statistically significant (P＞0.05).As aa,ab and bb of the HPA-2,3 change,the percent platelet recovery and platelet corrected growth index both decreased (P＜0.05).Conclusion Platelet transfusion refractoriness is related to HPA gene polymorphism,and allele b may be the cause of platelet transfusion refractoriness.

OBJECTIVE:To investigate the effects of tiotropium bromide assisted with bronchoalveolar lavage (BAL) on short-term efficacy,quality of life and re-hospitalization rate of patients with bronchiectasis complicated with lung infection. METH-ODS:A total of 140 patients with bronchiectasis complicated with lung infection selected from our hospital during Oct. 2013-Dec. 2015 were divided into control group and observation group by lottery,with 70 cases in each group. Based on intervention therapy, control group received BAL. Observation group was additionally given Tiotropium bromide powder inhalation 18 μg ,once a day before going to bed,on the basis of control group. Both groups were treated for 4 weeks. Clinical efficacy was compared between 2 group;pulmonary ventilation function indexes,blood gas analysis indexes,BODE index scores and QLI scores before and after treatment,re-hospitalization rate and the occurrence of ADR were also compared between 2 groups. RESULTS:The total response rate of observation group was 91.43%,which was significantly higher than that of control group(78.57%),with statistical signif-icance (P<0.05). Before treatment,there was no statistical significance in pulmonary ventilation function indexes,blood gas analysis indexes,BOED index scores or QLI scores between 2 groups(P>0.05). After treatment,FVC,FEV1,FEV1%,p(O2) and QLI score of 2 groups were increased significantly,while p(CO2)and BODE index scores were decreased significantly,com-pared to before treatment;all indexes of the observation group was significantly better than the control group,with statistical sig-nificance (P<0.05). The re-hospitalization rate of observation group 3,6 months after treatment was significantly lower thanthat of control group,with statistical significance(P<0.05). No ADR was found in 2 groups. CONCLUSIONS:For patients with bronchiectasis complicated with lung infection,tiotropium bromide assisted with BAL can effectively relieve the clinical symp-toms and signs,improve lung ventilation function and the quality of daily life and can be helpful to reduce the risk of re-hospital-ization with good safety.

Owing to climate influence, mean daily temperature in north China differs greatly from that of the southern regions during the same season. The introduction of Fritillaria thunbergii to Beijing for cultivation was hampered by delayed emergence of seedling and a shortened period for their growth, resulting in degeneration with the underground bulb becoming smaller year after year. With forcing culture as described in this paper, the emergence of seedling came earlier and growth period prolonged. The blossom and fruit became normal.By combining the method with formalin treated seed, diseases and pest index of the bulb were reduced distinctly and the yield increased with increased proportion of larger bulb year after year.

By means of HPLC,the changes of endogenous hormones in the process of releasing dormancy in Fritillaria thunbergii Miq. seeds were determined. The results indicated that the content of GA3 had a process of increase while the content of ABA was reduced in general. The content of IAA showed a downward -plateau-upward-downward curve in the process of releasing dormancy. When the dormancy of the seeds were released attemperatures 8~10℃ and 3~5℃,changing pattern of each of the three endogenous hormones were similar,but the duration spanning each change were different.

Objective To study the clinicopathologic features of giant cell carcinoma of the pancreas(GCCP). Methods The clinicopathologic features of 19 pathologically diagnosed as GCCP were retrospecti- vely analyzed in detail, compared with 96 cases of common pancreatic carcinoma (PC). Results Tumors that occurred in the head of pancreas were found in 8 patients(42.1%), and those in the body or tail of pancreas in 11 patients(57.9%). The initial symptom is mainly characterized by abdominal pain (57.9%). Abdominal pain (73.7%), dyspepsia(63.2%) and weight loss(36.8%) were common symptoms when patients were diagnosed. Jaundices is not a common symptom in these patients. The abnormal rates of routine laboratory tests were dramatically lower than those in common PC. The assay of tumor markers between GCCP and common PC were approximately same. The sensitivity and accuracy of diagnosis by ultrasonography, spiral computed tomography and magnetic resonance imaging were high. The carcinomas grew so large that 9 patients ( 47.4%)were in stage Ⅳ, the rate of which was higher than that in common PC. Osteoid formation was found under microscopy in some patients, and the tumor cells differentiated poorly in most of patients. The overall 1-year survival rate was 17.6%, which was lower than that in common PC. Conclusions The clinicopathologic features of GCCP are different from those of common PC. Imaging tests may be combined with the assay of tumor markers simultaneously so as to diagnose GCCP as early as possible and thus the prognosis of GCCP patients could be improved.

This study was aimed to assess the proportion and causes of misdiagnosis of pancreatic cancer (PC), and the effects of misdiagnosis on and treatment of PC, so as to sum up experiences and improve the diagnosis and treatment. 1027 cases with confirmed diagnosis of PC were retrospectively analyzed in detail. The patients were divided into misdiagnosed group and a group with correct diagnosis. The relevant data of the two groups were analyzed by stastical methods, and the differences between them were assessed. It was found that 586 cases (57 1%) were misdiagnosed.Fifty five diseases were involved in misdiagnosis, among them gastritis and duodenitis, peptic ulcer, virus hepatitis, cholecystitis and cholelithiasis, chronic pancreatitis wese the commonest. The differences of duration of diagnosis, main symptoms, resection rate, and half year survival rate between misdiagnosed group and correct diagnosis group were significant. It is concluded that PC is often misdiagnosed as other diseases. Early diagnosis and treatment is critical to the prognosis. The physician should be aware that PC may present a veriety of clinical manifestations, and therefore he or she should analyze comprehensively the symptoms and signs in order to improve diagnosis and treatment.

This study was conducted to assess the diagnostic value of serum CA19 9 in patients with pancreatic cancer. Seven hundred and seventy eight patients with the diagnosis of pancreatic cancer were involved in the study, and every patient had serum CA19 9 determined. The descriptive statistics and correlation analysis were used to evaluate the serum CA19 9 as an index in patients with pancreatic cancer. Results showed that 80 33% patients had the serum CA19 9 value higher than 37U/ml. Further more, a positive correlation was found between the serum CA19 9 and the TNM status of pancreatic cancer( r =0 513, P

To study the clinical features of the pancreatic cancer (PC), clinical symptoms of 1027 diagnosed cases of PC were retrospectively analyzed in detail, including their dynamic changes with regards to the patients'sexes, ages, blood types, and tumor locations in the pancreas. The results showed that abdominal pain, jaundice and epigastric discomfort were the prevailing initial symptoms in these 1027 cases. Abdominal pain, jaundice, weight loss, and anorexia were the main symptoms. Unusual symptoms were seemed to be different in different patients. The clinical symptoms could be dramatically different with difference in patients′ age and tumor location. The blood type might also infhluence the clinical symptoms in certain degree. It is concluded that the clinical symptoms of the PC were atypical in general, but still there were some characteristics.The physician should grasp these characteristic symptoms in order to make an early diagnosis.