PurposeTo evaluate the shear wave elastography in diagnosis of intraductal papillomas, benign or malignant breast lesions.Materials and Methods From December 2013 to December 2014, 145 female patients with 155 lesions who underwent ultrasonography and shear wave elastography in general hospital of PLA were retrospectively studied. All the lesions were confirmed by pathology via surgery or biopsy. The performance of the maximum elasticity, the mean elasticity, the minimum elasticity values and the elasticity ratio in diagnosis of benign and malignant tumors were analyzed. The portion of intraductal papillomas in misdiagnosed cases was calculated. The elasticity values of intraductal papillomas were compared with those of other breast benign and malignant lesions.ResultsAmong 155 lesions, pathology confirmed intraductal papillomas in 20 lesions, fibroadenosis in 23 lesions, fibroadenoma in 23 lesions, inflammation in 9 lesions, adenosis with fibroadenoma in 17 lesions, and breast cancer in 63 lesions. The maximum, mean, minimum elasticity values and the elasticity ratio of intraductal papillomas were (84.39±74.08) kPa, (51.33±46.36) kPa, (26.55±24.98) kPa and 2.80±2.18, respectively. The elasticity values of intraductal papillomas were between those of breast cancer and other benign lesions, and there were no statistically significant (P=0.003).ConclusionThe elasticity values of intraductal papillomas were between those of breast cancer and other benign lesions, which may be a potential reason to cause misdiagnosis using shear wave elastography to differentiate breast benign and malignant diseases.

Objective]The article summarizes the essentials of hyperprolactinemia infertility experience by Professor Wang Zhe. [Methods]From following Professor Wang Zhe clincial studies,summarize experience and thoughts of treating hyperprolactinemia infertility with a case. [Results]Professor Wang Zhe thinks the main reason for the occurrence of hyperprolactinemia infertility ,which is related to the dysfunction of the liver,spleen and kidney.The spleen rules transformation and transportation that like dryness and dislike dampness.The liver stores the blood and rules flowing and spreading, that is sensitive to boundaries and maintains the smoothness and harmony of movement throughout the body.The kidneys store the essence and rule birth and hiding, which is foundation of innate existence. Its main types are liver depression and deficiency of the kidney block and phlegm-dampness stagnation.Therapeutically,using Fu Qingzhu medicine for women in the study of Yangjingzhongyu Decoction and the Ye Tianshi treatment recipe for women refers to Cangfudaotan Decoction in the treatment,to achieve nourishing the liver and kidney, invigorating spleen for eliminating dampness.[Conclusion]Professor Wang has exquisite medical skills, rigorous academic attitude, and richly professional knowledge and clinical experience.She has unique insights and experience in treating hyperprolactinemia infertility.Professor Wang Zhe's experience hopes to expand ideas of the clinical diagnosis and treatment.

Epstein-Barr virus (EBV)infection is highly prevalent in general population,serum EBV antibody can be detected in about 90% of the adults.Forty years of researches have demonstrated that EBV infection is closely related to a variety of hematological diseases,such as infectious mononucleosis, EBV-related lymphoproliferative disorders,lymphoma and hemophagocytic syndrome.This paper reviews EBV-associated hematological diseases and its pathogenic mechanism.

Objective: To examine the emotional states of asthmatic children with different degrees of severity, as well as the effects of emotion on change of cytokines in airway. Methods: Asthmatic children were divided into two groups according to the degrees of severity: moderate and mild. Their emotional states were measured and results were compared. Correlation analysis was conducted between scores on emotional scales and sputum levels of IL-8.Results: Total scores on anxiety and depression were higher in the moderate group than in the mild group. Negative correlation was found between levels of anxiety and IL-8 during acute exacerbation of asthmatic condition. Conclusion: Emotional distress was found to be increased with severity of asthmatic condition in children. Anxiety contributed to the decreased concentration of IL-8 in asthmatic children's airway.

Objective To investigate the preventive effect of 1,25-dihydroxyvitamin D_3 〔1,25-(OH)_2D_3〕 on type 1 diabetes in cyclophosphamide-treated NOD mice. Methods Twenty female NOD mice were administered 280 mg/kg cyclophosphamide by a single intraperitoneal injection at the beginning of the experiment and then divided into two equal groups. Group 1 received intraperitoneal injection of 5 ?g/kg 1,25-(OH)_2D_3 every other day; Group 2 received the intraperitoneal injection of peanut oil in the same volume as control. When the experiment was finished on the 30th day, the incidence of diabetes and the degree of insulitis were observed. The expressions of bcl-2 and bax in islets were detected with immunohistochemical technique. The apoptosis rate of spleen T lymphocyte was also measured by flow cytometry quantitative analysis. Results Intraperitoneal injections of 1,25-(OH)_2D_3 to NOD mice reduced the incidence of diabetes (10% vs 70%, P

[Objective]To investigate the curative effect and methods of distal tibial fracture by operation.[Method]From May 2004 to Feb.2005,30 cases of distal tibial fracture were treated in the department.All cases were treated with open reduction,internal fixation with medial anatomic plates,and with bone-grafting prophylacticly in all cases.The operation would be done on 10~14 days after fracture.They were followed up and analyzed retrospectively.[Result]All cases were followed up for 8～17 months(average 13.9 months).All wounds were primary healing and all fractures obtained bone-union.Twenty-two cases were the excellent,6 cases were the good according to Mazur's criteria.The excellent and good rate was 93.3%.All cases had no severe complication,such as wound infection,cutaneous necrosis and bone non-union.[Conclusion]Anatomic plate of distal tibia is a perfect choice for treatment of distal tibial fracture.Operative juncture and prophylactic bone grafting were very important to obtain satisfactory effect.

OBJECTIVE: To investigate the effect of LARS artificial ligament on reconstruction of anterior and posterior cruciate ligament of keen joint.METHODS: Articles addressing reconstruction of anterior and posterior cruciate ligament by LARS artificial ligament were retrieved from VIP database (http://www.cqvip.com/) with the key words of "LARS artificial ligament, cruciate ligament,reconstruction" in Chinese between January 2000 and February 2010.Inclusion criteria: advantages and disadvantages of reconstructing anterior and posterior cruciate ligament by LARS artificial ligament; clinical application of reconstructing anterior and posterior cruciate ligament by LARS artificial ligament.Exclusion criteria: Duplicated studies or old references were excluded.A total of 31 articles were included in the final analysis.RESULTS: Reconstruction of anterior and posterior cruciate ligament by LARS artificial ligament characterized by convenient operation, short operative time, mild trauma, engaging in movement early, great strength, simple implantation, and reliable fixation; however, most patients were not able to bear the high medical cost, thus clinical application was limited.Scholars thought that LARS artificial ligament had great effects on reconstruction of anterior and posterior cruciate ligament.CONCLUSION: Patients who had multi-ligament injury, overhauling of ligament, and early movement were treated with LARS artificial ligament.

BACKGROUND: The small change of the membrane potential (Em) of vascular smooth muscle cells (VSMC) could result in significant alteration in tension, and the membrane depolarization was closely associated with the development of hypertension.OBJECTIVE: To study the resting Em of VSMC from the middle cerebral artery (MCA) of stroke-prone spontaneously hypertensive rats (SHRSP) and the reactivity of Em to KCl and norepinephrine (NE).DESIGN: An animal experiment of comparative analysis.SETTING: Institute of Materia Medica, Shandong Academy of Medical Sciences.MATERIALS: Eighteen male SHRSP and 26 male Wistar rats were used.METHODS: ① Rats in both groups were anesthetized with intraperitoneal injection of ethyl carbamate (1 g/kg), the brains were removed quickly, and the Em of VSMC was recorded by intracellular microelectrodes. ② The effects of different concentrations of KC1 (10, 20, 50 mmol/L) and NE (10-7,10-6, 10-5 mol/L) on the Em of VSMC were observed.MAIN OUTCOME MEASURES: ① Em of VSMC in both groups; ②Effects of different concentrations of KC1 and NE on the Em of VSMC.RESULTS: ① The Em was obviously lower in SHRSP than in the Wistar rats [(-48.2±3.1), (-64.4±4.3) mV]. ② Both KC1 (10, 20, 50 mmol/L)and NE (10-7, 10-6, 10-5 mol/L) could cause the depolarization of Em of MCA in a concentration-dependent manner. The reactivity to MCA of SHRSP was obviously increased as compared with the Wistar rats.CONCLUSION: The resting Em of VSMC from the MCA of SHRSP was lower, and the reactivity of VSMC to KCl and NE was significantly stronger than that of Wistar rats.

Objective To obtain the elasticity value of non-mass-like breast lesions with supersonic shear wave elastrography (SWE), in order to observe the value of quantitative elastography with SWE in differential diagnosis of non-mass-like breast lesions. Methods SWE was performed in 80 non-mass-like breast lesions. Taking pathologic results as reference, quantitative elasticity value of the lesions were performed. The diagnostic accuracy, sensitivity and speciifcity were calculated. Results In the 80 non-mass-like breast lesions, 37 lesions (46%) were malignant and 43 lesions (54%) were benign. The max and mean elasticity value of malignant lesions were (106.28±46.39) kPa and (51.02±30.06) kPa, and the max and mean elasticity value of benign lesions were (37.13±18.22) kPa and (26.44±15.62) kPa. There was statistical differences between malignant and benign lesions in max and mean elasticity values (t=15.328, 18.149, both P<0.05). Taking 61.25 kPa as the threshold of max elasticity value and 40.65 kPa as the threshold of mean elasticity value, the diagnostic accuracy, sensitivity and speciifcity were 70.53%, 66.83%, 51.22%and 68.34%, 65.81%, 50.63%, respectively. When max elasticity was combined with conventional ultrasound (US), the diagnostic accuracy, sensitivity and speciifcity were 84.17%, 92.28%and 68.39%, respectively. The diagnostic accuracy and speciifcity signiifcantly increased compared with conventional US (χ2=5.217, 9.652, both P<0.05). When mean elasticity was combined with conventional US, the diagnostic accuracy, sensitivity and speciifcity were 82.35%, 90.66%, and 63.35%, respectively. The diagnostic accuracy and speciifcity signiifcantly increased compared with conventional US (χ2=5.084, 8.686, both P<0.05). Conclusions The diagnostic accuracy and speciifcity of SWE for non-mass-like breast lesions are not high. But when SWE is combined with conventional US, the diagnostic accuracy and speciifcity increase signiifcantly, which is very helpful for the diagnostic of non-mass-like breast lesions.