Objective To develop health supervision information system. Methods The operation needs for health supervision department are analyzed; the object-oriented method is used to build the structure based on C/S mode, the client software is programmed by Delphi languages and Oracle is adopted as the database for its server. Results The functions of the health supervision system are realized including permission, inspection, punishment, statistical analysis and instruments print and so on. Conclusion The information system can be fulfilled the business needs of the health supervision department and enhanced inspection efficiency.