Objective:To study the effect of controllable abdominal breath in treatment of migraine.Method:20 patients(10 male,10 female,aged 20-30 years)with migraine according to international diagnostic standard published 1990 were randomly divided into study group and control group.The study group received training of controllable abdominal breath.All subjects were followed for 3 months.Changes of symptoms and hemorhelogy were recorded.Result:Study group improved in both symptom and index of hemorheology after treatment,and the results were better than that of control.Conclusion:Controllable abdominal breath is effective in treatment of migraine.

Objective To investigate the reliability of the morphologic measure of the iliotibial band (ITB) with musculoskeletal ultrasound imaging. Methods 20 healthy young subjects were measured with the musculoskeletal ultrasound imaging of the thickness of bilateral ITB at the levels of the femoral condyle by 2 testers, and one of the testers measured again 3-5 days later. The intraclass correlation coefficient (ICC) and minimum detectable change (MDC) were calculated, and the thickness of ITB in both sides was compared. Results The ICC of test-retest was 0.89 (R) and 0.85 (L), and it was 0.82 (R) and 0.84 (L) of inter-testers. The MDC was 0.41-0.51 mm. There was no significant different between right and left sides for the ITB thickness among healthy subjects (P=0.97). Conclusion Musculoskeletal ultrasound imaging is a feasible and reliable to measure the ITB thickness among young healthy subjects.

Objective To investigate the relationship between H type hypertension as well as the changes of serum lipid and white matter lesions(WML).Methods From January 2015 to October 2017,the clinical characteristics of 507 WML patients who admitted to the Affiliated Hospital of Chengde Medical College were analyzed retrospectively. The patients were divided into simple hypertension group(A group,hypertension accompanied by Hcy ＜10μmol/L, 111cases),simple homocysteine group(B group,patients without high blood pressure with homocysteine ＞10μmol/L, 132cases)and H type hypertension group (C group,hypertension accompanied by homocysteine ＞10μmol/L,264cases)according to homocysteine concentration and hypertension.The patients'clinical data,including imaging information such as MRI,diffusion weighted imaging(DWI),and levels of homocysteine (Hcy),serum lipid were collected.The patients were divided into three subgroups based on the severity of WML,including the mild,moderate,severe.The differences of TG,TC,HDL -C,LDL -C,Apo -A1,Apo -B in each group were compared.Results The levels of TC in A,B and C group were (4.14 ±1.16)mmol/L,(4.39 ±1.39)mmol/L,(3.67 ±1.29)mmol/L,respectively.The levels of LDL -C in the three groups were (2.24 ±0.88)mmol/L,(2.38 ±0.91)mmol/L and (1.99 ±0.89)mmol/L,respectively.Compared with A group and B group,the levels of TC and LDL -C in C group were lower(F =15.411,9.271,all P <0.05).In A group,the number of mild WML,moderate and severe WML accounted for 51.4%,32.4% and 16.2%,which in B group accounted for 50.0%,33.3% and 16.7%,which in C group accounted for 32.6%,33.3% and 34.1%.The number of WML patients had statistically significant differences between A group and C group(χ2 =16.407,P <0.05),and B group and C group(χ2 =15.912,P <0.05).In A group,the TC levels in the moderate group [(4.45 ±1.07)mmol/L]and severe group[(5.04 ±0.99)mmol/L] were significantly higher than that in the mild group [(3.68 ±1.03)mmol/L],the difference was statistically significant(F =22.391,P <0.05);the LDL -C level in the severe group[(2.88 ±0.65)mmol/L]was significantly higher than (1.98 ±0.84)mmol/L in the mild group and (2.33 ±0.89)mmol/L in the moderate group(F =14.764,P <0.05).In B group,the TC levels in the moderate group [(4.79 ±1.38)mmol/L]and the severe group [(5.20 ±1.43)mmol/L]were significantly higher than (3.85 ±1.16)mmol/L in the mild group,the difference was statistically significant(F =20.515,P <0.05).Compared with the mild group[(2.13 ±0.83)mmol/L],the LDL –C level was higher in the severe group[(2.81±1.01)mmol/L],the difference was statistically significant(F =9.235, P <0.05).In C group,the levels of TC and LDL -C in the moderate group were (3.94 ±1.22)mmol/L and (2.02 ± 0.74)mmol/L,respectively,which in the severe group were (3.93 ±1.16)mmol/L and (2.30 ±0.85)mmol/L,respectively,which were significantly higher than those in the mild group [(3.12 ±1.34 )mmol/L,(1.62 ±0.88)mmol/L],the differences were statistically significant(F =27.141,27.078,all P <0.05).Spearman correlation analysis showed that there was a positive correlation between hypertension,TC,LDL -C and the severity of WML(H type hypertension:r =0.211,P <0.05;TC:r =0.266,P <0.05;LDL -C:r =0.258,P <0.05).Conclusion H type hypertension and high levels of TC,LDL -C can increase the number and severity of WML.

Objective To investigate the value of combined serum levels of neutrophil gelatinase-associated lipocalin(NGAL)and growth differentiation factor 15(GDF-15)in diagnosis of renal injury in elderly patients with H-type hypertension.Methods A total of 177 patients with H-type hypertension admitted to Department of Neurology and Department of General Medicine of the Affiliated Hospital of Chengde Medical College from April 2021 to June 2022 were enrolled,and based on their estimated glomerular filtration rate(eGFR),they were divided into the renal im-pairment group(81 cases)and normal renal function group(96 cases).General data and laboratory indicators were collected in the two groups.ROC curve analysis was used to evaluate the diagnos-tic value of combined NGAL and GDF-15 levels for renal injury in the elderly patients with H-type hypertension,and Pearson correlation analysis was performed to analyze the correlation between serum NGAL and GDF-15 levels and renal injury in the patients.Results SBP level was significantly higher in the renal impairment group than the normal renal function group[148.53±14.62 mm Hg(1 mm Hg=0.133 kPa)vs 138.75±13.36 mm Hg,P＜0.01],but no such difference was observed in DBP level between the two groups(P＞0.05).The levels of creatinine(Cr),urea nitrogen(BUN),β2-microglobulin(β2-MG),cystatin C(Cys C),urinary microalbumin(MA),NGAL and GDF-15 levels were obviously higher in the renal impairment group than the group with normal renal function(P＜0.01).ROC curve analysis showed that the combined detection of NGAL and GDF-15 levels was significantly higher than that of the two indicators alone(P＜0.01).Pearson correlation analysis indicated that serum NGAL and GDF-15 levels were positively correlated with Cr,BUN,β2-MG,Cys C and MA levels(P＜0.01).Conclusion Serum NGAL and GDF-15 levels are elevated in elderly H-type hypertension patients.Combined detection of the two indicators has higher value in the diagnosis of renal injury in elderly H-type hypertension patients.

Objective To explore the correlation between the expression of long non-coding RNA(lncRNA)brain ischemia-related factor(BIRF)and focally amplified lncRNA on chromosome 1(lncRNA FAL1)in serum and the degree of white matter lesions(WML)in patients with cerebral small vessel disease(CSVD).Methods From June 2021 to June 2023,102 CSVD patients admitted to Affiliated Hospital of Chengde Medical University were collected,and these patients were grouped into WML group(n=72)and non WML group(n=30)based on WML diagnostic criteria.According to the Fazekas score,the WML group was further grouped into mild WML group(n=24),moderate WML group(n=36)and severe WML group(n=12).Real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)was applied to detect the levels of lncRNA BIRF and lncRNA FAL1 in serum.Pearson correlation was applied to analyze the correlation between serum lncRNA BIRF and lncRNA FAL1 levels.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum lncRNA BIRF and lncRNA FAL1 levels for severe WML in CSVD patients.Results The age(70.50±5.86 years),history of hypertension(Yes/No,43/29),history of diabetes(Yes/No,45/27),IL-33(68.35±6.80 pg/ml),IL-18(97.78±9.65 ng/L),ubiquitin carboxyl terminal hydrolase L1(UCH-L1)(0.29±0.10 μg/L)and lncRNA BIRF level(2.45±0.30)of patients in the WML group were higher than those in the non WML group(67.10±5.76 years,11/19,9/21,62.48±6.13 pg/ml,92.56±9.37 ng/L,0.24±0.06 μg/L,1.02±0.11),while the expression of serum lncRNA FAL1(0.52±0.10)was lower than that in the non WML group(1.04±0.15),with significant differences(t=2.683,4.518,8.978,4.085,2.510,2.550,25.346,20.500,all P<0.05).The serum lncRNA BIRF levels of CSVD patients in the mild,moderate and severe WML groups(2.23±0.23,2.47±0.31,2.82±0.42)were increased sequentially,while the expression of serum lncRNA FAL1(0.60±0.15,0.51±0.09,0.40±0.04)was decreased sequentially,with significant differences(F=14.913,13.899,all P<0.05).Pearson correlation analysis,the serum levels of lncRNA BIRF and lncRNA FAL1 in patients with WML were negatively correlated(r=-0.603,P<0.001),serum lncRNA BIRF was positively correlated with Fazekas score in WML patients(r=0.483,P<0.001),but serum lncRNA FAL1 was negatively correlated with Fazekas score(r=-0.507,P<0.001).The AUCs of serum lncRNA BIRF and lncRNA FAL1 levels alone and both combination for predicting severe WML in CSVD patients were 0.756(0.641～0.850),0.839(0.733～0.915)and 0.892(0.796～0.953),respectively,and the combination of the two was superior to the detection of serum lncRNA BIRF alone(Z=2.111,P=0.035).Conclusion The serum lncRNA BIRF level is increased and lncRNA FAL1 is reduced in patients with CSVD and WML,and both are related to the degree of WML in CSVD patients.