Digoxin was administered to young dogs orally so as to determine concentration of serum digoxin by means of periodic radioimmunoassay followed by clinical observation and EKG changes.Dogs were divided into four groupsshigher and lower maintenances groups ("HM" "LM")and lower and higher saturation groups("LS" "HS") .Serum concentration level of "LM" and "HM" groups rose to the peak in 3-6 days after digoxin administration. The stable serum level reached 0.63?0.32 ng/ml and 0.67?0.07 ng/ml.The peak of serum concentration in "LS" and "HS" groups appeared in 2 hours after medication and persisted for 24 hours, then declining to a level of 1.39?0.13 ng/ml and 1.58?0.09 ng/ml with relative stability, with the exception of a few samples which exceeded 3 ng/ml, being more as in "HS".According to the experimental results dosage of digoxin for children was discussed.

Twenty-five children with cardiac failure were treated with the mainte-nance small dosage(0.01 mg/kg/day). The serum digoxin concentration was identified by periodic 125 I-digoxin radioimmunoassay and monitored by EKG. partial symptoms of cardiac failure improved after 24 hrs. A large number of the patients got better significantly 3-5 days later and cardiac failure was controlled.The serum digoxin concentration was 0.815?0.1 ng/mg after 24 hrs, then elevated gradually. The range of serum concentration was about 0.664-1.187 ng/ ml from the 4th on to the 4th week after medication. The mean concentration of serum digoxin in two patients was 0.835 ?0.163 ng/ml in 12 wks.No toxicity symptoms were found except in 2 cases with precardiac beat. The authors suggest that persisted serum digoxin concentration in about 1 ng/ ml is safe and effective.Thus, it is considered that this method could be applied to not very ill children of all ages in OPD where no satisfactory observation can be made.

The right ventricular systolic intervals(RSTI)in health neonates were determined in 72 cases within 6 days after delivery. The RSTI of 22 neonates were compared with before and after inspirated oxygen of high concentration (5 1/min.) within 24 hrs after delivery. Every paremeter of RSTI in each group was contrasted with those of other group in differnt times(or days)The main appearances were significantly,such as shortness of RPEP, prologation of RVET, RPEP/RVET and RICT/RVET decreased.It showed that the right ventricular load was decreased.The ratio among RPEP/RVET, RICT/RVET and neonatal daily age was minus relationship by double curve regression analysis(p

Sixty-one healthy children, aged 4 to 12 years, were divided into two groups and examined with 21 cardiac function parameters. They included ejection function (SV, CO, and SVI), systolic function (EF, △D%, MVCF, ESV and △T%), dia-stolic function (EFV, EPSS, EDV)and systolic time interval (LPEP, LVET, LICT, LPEP/LVET,LICT/LVET,RPEP, RVET, RICT, RPEP/RVET and RICT/RVET). Signification of progressive retrogradation analysis with children's age, sex, body surface and heart rate was evaluated respectively.

Objective To investigate the diagnostic value of MR cholangiopancreatography(MRCP) and volume imaging body exam(VIBE) in the obstructive jaundice.Methods 119 patients with obstructive jaundice underwent MRI examination of upper abdomen using the special sequences of MRCP and VIBE.The qualitative diagnosis of obstructive jaundice was evaluated with MRCP and VIBE in comparison with that of percutaneous transhepatic cholangiography(PTC),endoscopic retrograde cholangiopancreatography(ERCP) and operation.Results The corresponding diagnostic rate was 94.1% for obstructive jaundice with MRCP and VIBE,of that the corresponding rate in calculus obstruction,malignant obstruction,and the benign obstruction except calculus obstruction was 100%,94.3% and 83.9% respectively.There was significant difference between malignant obstruction and benign obstructive(P

The levels of plasma immunoreactive atrial natriuretic polypeptide (ir-ANP) were determined by radioimmunoassay in 59 children with congenital heart disease (CHD). It was showed that the ir-ANP levels of the patients with left to right shunt were higher than those of control (P0.05). The iir-ANP levels of patients with HYHA II degree were increased significantly (P

45 cases of childhood extrinsic asthma (CEA) were divided into the treatment group with carboxymethykited starch (CMS) (n=30) and the control group (n=15). The total effective rate of the former was 63% (P

Background Orbital fracture in children has its own characteristics.Choosing the suitable plastic materials is the effective measurement to improve the successful rate of surgery.Absorbable plate filling provides a new material for children with orbital fracture.However,few studies compare the effectivity and safety between absorbable plate filling and conventional filling.Objective The aim of this study was to compare the longterm efficacy and safety between absorbable plate and Medpor implants in the repair of pediatric orbital fracture.Methods Clinical data of 72 eyes of 72 pediatric patients with orbital fracture who received surgicals reconstruction in Beijing Tongren Eye Center from 2008 April to 2014 August were respectively analyzed,including 28 patients with absorbable plates filling and 44 patients with Medpor implants.Demography and preoperative clinical signs were matched between the two groups.Operative procedure was same except the implanted materials.The functional training of extraocular muscle was performed since the second day after surgery in both groups.The imaging findings of the orbit were evaluated by computed tomography (CT) before and after surgery.The patients were followed-up for avarage 12.7 months after operation.The therapeutic effectiveness and safety were compared between the different implants,such as incidence of enophthalmos,extraocular movement impairment and diplopia,and the sensory deficit of skin and complications were documented.Results Extraocular muscle movement improved and diplopia alleviated or disappeared in 92.9％ (26/28) in the absorbable plate group and 90.9％ (40/44) in the Medporgroup,without significant difference between the two groups (P=0.57).The sensory deficit of skin was found in 13 eyes (46.4％) and 20 eyes (45.5％ in the absorbable plate group and Medpor group,respectively,and there was no significant difference between the two groups (P =0.56).CT revealed that the anatomical reconstruction of orbits could be achieved in all patients in both groups without the shifting of implants and extrusion.No enophthalmos and postoperative infection were found in absorbable plate group,however,the residual enophthalmos or late infection was found in I eye for each in the Medpor group.Conclusions Both the absorbable plate and Medpor implants show good results for reconstruction of pediatric orbital fracture.Absorbable plate is an ideal material for pediatric orbital blowout fracture because of fewer postoperative complications.

Objective:To preliminarily observe the clinical efficacy of microwave hyperthermia combined with intensity-modulated radiotherapy (IMRT) and chemotherapy for patients with locally advanced gastric cancer.Methods:Forty patients who could not been operated or refused operation were enrolled in this clinical trial, who were confirmed as locally advanced proximal or distal gastric cancer by gastroscopy pathology and imaging. Radiotherapy was delivered by IMRT technology for 5 times per week with a total dose of 46 to 56 Gy (median dose of 50 Gy) in 25 to 28 fractions. Synchronous hyperthermia was given at 42 to 44℃ twice a week, 45 min/time. S-1 or capecitabine-based synchronous chemotherapy was performed, d1-14/3 weeks. The symptom remission rate, adverse reactions, objective remission rate (complete and partial remission) and survival were observed.Results:A total of 40 patients, aged between 56 and 83 years (median age of 71 years), were enrolled in this study. The male-to-female ratio was 7: 1. Among them, 38 cases (95%) showed symptom remission. The most common adverse reactions were grade 1-2 gastrointestinal reactions and leukopenia. The objective remission rate was 87.5%, the 2-year progression-free survival and overall survival rates were 68.6% and 70.5%, respectively.Conclusion:Preliminary findings demonstrate that microwave hyperthermia combined with chemoradiotherapy achieve satisfactory outcomes and yield tolerable toxicity in patients with locally advanced gastric cancer.

Objective To explore the memory function and the effects of sleep on memory consolidation in patients with stable paranoid schizophrenia.Method Sixty patients with stable paranoid schizophrenia were randomly assigned into research group (n =30) and control group (n =30).30 healthy people were raised as a healthy control group.The polysomnography (PSG) was used for 10 hours of sleep monitoring in the research group and the healthy control group and the muhiple memory assessment scale(MMAS) was used to test the subjects memory before and after the sleep monitoring.Control group performed memory tests in equal length daytime.Pre-test and post-memory measurements were compared.Results The prememory test of three groups had significant statistical differences (F(2.87) =31.40,39.89;P＜0.01).Both the auditory verbal/picture memory conservation rate and recognition accuracy rate between research group and healthy controls had no statistically significance differences (P＞0.05).But compared with the control group,auditory verbal memory conservation rate ((62.64±9.06) ％ vs (43.00±9.73) ％,P＜0.01),recognition accuracy rate ((69.11±11.04)％ vs (61.78±11.67)％,P＜0.05),picture memory conservation rate((71.20±14.95) ％ vs (58.72 ± 16.19) ％,P＜ 0.01),recognition accuracy rate ((86.89 ± 8.02) ％ vs (78.89 ±12.63) ％,P＜0.01) of the research group showed statistical significance differences (P＜0.05).Both N2 (r=0.377,P＜0.05) and REM (r=0.436,P＜0.05) had positive correlation with recognition accuracy rate of auditory verbal memory in research group.Conclusion Stable paranoid schizophrenic patients have poorer memory function(auditory verbal words memory recall,picture memory recall) than healthy people.Sleep promotes the consolidation of memory in patients with schizophrenia.Both N2 and REM of patients with stable paranoid schizophrenic have positive correlation with recognition accuracy rate of auditory verbal memory.