Near infrared (NIR) spectroscopy as a rapid and nondestructive analytical technique, integrated with chemometrics, is a powerful process analytical tool for the pharmaceutical industry and is becoming an attractive complementary technique for herbal medicine analysis. This review mainly focuses on the recent applications of NIR spectroscopy in species authentication of herbal medicines and their geo-graphical origin discrimination.

OBJECTIVE:To study the preparation method of ranolazine sustained release tablets and to optimize the preparation technology conditions for these preparations. METHODS: The preparation technology conditions were optimized by orthogonal design with the amounts of HPMCP, MC, PH101 and the hardness of ranolazine sustained release tablets as indexes. The optimized results were verified and the in vitro release of ranolazine sustained release tablets was determined. RESULTS: The optimum preparation technology conditions of ranolazine sustained release tablets were as follows: the amounts of HPMCP, MC, PH101 and the hardness were 150mg, 75mg, 30mg, and 10kg, respectively; and the in vitro release rates at 2, 6, and 12h were (29.33?1.05)%, (59.9?1.53)% and (95.60?1.31)%, respectively. CONCLUSION: The delayed release effect of ranolazine sustained release tablets coincided with the predictive value on the whole, and the preparation technology was reproducible. The in vitro accumulated drug release was in conformity with the requirements.

OBJECTIVE:To explore the rational structure of hospital drug charge in state hospitals and the approaches to improve the reimbursement mechanism for state hospitals.METHODS:The detailed document about"reforming or cancelling the drug price addition policy in state hospitals"stated in the Proposals on Deepening Reform of Medical System were analyzed. RESULTS & CONCLUSIONS:"Reforming or cancelling the drug price addition policy in state hospitals"does not necessarily mean the simply cancelling of drug price addition policy in state hospitals,instead,it was achieved by establishing reasonable structure of hospital drug charge and improving the reimbursement mechanism for state hospitals guaranteed by complete operational approaches and supporting policy.

The distance between the main branches of intrahepatic duct and the Surface of the liver was measured on the stripping specimens of 30 adult livers.The results of this study will pro- vide anatomical data for the percutaneous transhepatic cholangiography.

conduction of institutionalized and stanardized education for rural doctors is one of the specific measures that can be taken to put into effectt the gist of the documents issued by the State Council, realize healthcare for all people in the rural areas of China by the year 2000, and imprvove the quality of medical services in the rural areas. The steps taken by Yun County include: ①strengthening leadership so as to guarantee the smooth conduction of the work; ②establishing training hases so as to provide the necessary environment; ③working out policies so as to create the right circumstances; and ④consolidating measures so as to bring into ply the ndhative of rural doctors in participating in the education. As a result of the above steps, health stations have ho set up in all the 396 administrative villages throughout the county, with the average number of rural doctors in each village being 1.47. 86. 1% of these rural doctors have participated in the education, with the newly employed 29 ed doctors all having received technical secondary education in health. Yet the construchon of the contingent of ed doctors is still confronted with some problems needing prompt solution.

Objective:To discuss the clinical application with choledochoscope paul gall stone under laparoscopic. Methods: Selected 45 cases of gallbladder stones with extrahepatic bile duct stones in patients as research subjects in the first general surgery 242 hospital of harbin from January 2010 until May 2013. used a random number table, patients were divided into two groups,25 cases in the observation group, used laparoscopic Choledochofiberscope Paul gall stone surgery;the control group of 20 patients, used laparoscopic cholecystectomy, compared surgical results, surgery and hospitalization data, postoperative complications situation. Results: Clinical efficacy markedly effective, ineffective, the total efficiency of the treatment was statistically significant; hospitalization, surgery time comparing the results with statistical significance;patients with diarrhea, complications steatorrhea, pancreatitis, stone recurrence comparison, the results are statistically significant. Conclusion:Paul Choledochofiberscope laparoscopic gall stone surgery can effectively improve the efficiency of treatment, and have shorter operative time, surgical advantages of simple, easy to control while surgery, gallbladder and bile duct stones are better minimally invasive treatment.

Objective To observe the effect of flapless minimally invasive technique in oral dental implants and prognosis.Methods 31 patients dental implant were collected (flapless minimally invasive group),the group planted alveolar ridge width greater than 4mm and plenty of bone.The other 31 cases patients concomitant select flapless implant dental were collected as control(flap lminimally invasive group).The clinical effect was analyzed retrospectively.Results Flapless minimally invasive surgical time was (22.88 ± 3.17)min,duration of postoperative pain (30.26 ± 8.53) h,antibiotics (32.74 ± 8.96) h,were significantly reduced compared with flap minimally invasive group(all P ＜ 0.01).Conclusion Minimally invasive flapless implant maintains the integrity of the original structure of the gum tissue and bone tissue,as well as the native conformation,which has good prognosis.However,patients with poor bone conditions in growing areas are still irreplaceable by flapless minimally invasive implantation.

Conduction of institutionalized and standardized education for nnal doctors is one of the specific measures that can be taken to put into effect the gist of the documents issued by the State Council, realize healthcare for all people in the rural areas of China by the year 2000, and improve the quality of medical services in the rural areas. The steps taken by Yun County include: ①strengthening leadership so as to guarantee the smooth conduction of the work; ②establishing training bases so as to provide the necessary environment; ③working out policies so as to create the right circumstances; and ④consolidating measures so as to bring into play the initiative of nual doctons in participating in the education. As a result of the above steps, health stations have been set up in all the 396 administrative villages throughout the county, with the average number af rural doctors in each village being 1.47. 86.1% of these rural doctors have participated in the education, with the newly employed 29 rural doctors all having received technical secondary education in health. Yet the construction of the contingent of rural doctors is still confronted with some problems needing prompt solution.

Objective To measure D-Dimer(DD) ,thrombin-antithrombin complex(TAT), lasmin-antiplasrain complex(PAP) and protein C(PC) in ARDS,to find the clinical significance of them,discuss the objective base in the early diagnosis of ARDS in the lab, and offer the serologic bases in the treatment and prognosis of ARDS.Methods 105 patients of ARDS were selected as the study group, and 105 people were selected as the control group, all of whom were healthy with no thrombus diseases. The venous blood of everyone in both groups was sampied,in order to take a quantitative determination of plasma prothrombin time(PT), prothrombin time(TT), kadin partial thromboplastin time(APTT), the amount of blood platelet, DD, TAT, PAP, PC. Results Serum concentratation of D-D, TAT, PAP was significantly higher in patients in ARDS group than that in control group(P＜0.01).Serum concentratation of PC was significantly lower in patients in ARDS group than that in control group (P＜0.01). Conclusion Measuring the concentration of DD, TAT, PAP and PC was very important, which not only did good to the early diagnosis of ARDS,but also had a clinic value.

The subject of this study is to improve the ability of Ralstonia metallidurans CH34, a phenol-degrading strain with anti-heavy metal feature by immobilization.The optimal conditions for immobilizing bacterial cells were obtained with cross act experiment. The phenol-degrading efficiency of immobilized Ralstonia metallidurans CH34 was investigated. Results show that phenol-degrading efficiency of immobilized cells is obviously superior to that of the free cells; The ability of its resistance to heavy metal have been greatly improved; When additional carbon sources were added in the simulated waste water, the immobilized R. metallidurans CH34 were affected less than the free cells.