There is a great controversy over the application of corticosteroids in preventing and treating bronchopulmonary dysplasia(BPD).Prenatal use of corticosteroids may reduce the occurrence of BPD.Intravenous corticosteroids within 1 week after birth can reduce the incidence of BPD.However,in light of the short and long-term adverse reactions,it is not recommended.For premature infants with BPD in high risk,clinicians should weigh the pros and cons and may apply a small dose,short course of corticosteroids for intervention in 1 week after birth.Early inhalation or instilling of corticosteroids may be an effective and safe way to reduce the occurrence of BPD.

Objective:To provide a new idea for the management of drug inspection standards. Methods: The current manage-ment mode for drug inspection standards was analyzed and studied, the problems and difficulties were summarized, and then a novel i-dea and method of electronic management was formulated. Results: The electronic management for drug inspection standards could solve the problems encountered in the traditional management effectively and improve the management efficiency. Conclusion: The standard management information system can provide drug inspection standards in time and ensure the effectiveness, which is very help-ful to the drug inspection.

Pancreaticogastrostomy appears as a method of pancreatic digestive tract reconstruction after pancreaticoduodenectomy.Its research mainly includes incidences of pancreatic-fistula,pancreatic exocrine and endocrine function and methods of pancreaticogastrostomy,which is frequently compared with pancreaticojejunostomy.In this review.The author will discuss these problem and review.The history of pancreaticogastrostomy.

Objective To study the effect of combined vitamin therapy of B2 and Zhibai-Dihuang Wan on recurrent oral ulcer.Methods A total of 178 patients with recurrent oral ulcer were randomly recruited into a control group and a treatment group.The control group was treated with vitamin B2,0.2g/time,3 times/day;while the treatment group WaS treated with Zhibai-Dihuang Wan,9g/time,twice/day,on the basis of the control group.The therapeutic effects were observed in both groups after 14 days.Results The obvious effective rate in the treatment group was significantly higher than the control group(P=0.0083).while total effective rate did not show significant difierence between the two groups(P=0.0712).The relapse rate in the treatment group was significant lower than the control group.Conclusion It is effective to treat recurrent oral ulcer with the combination of vitamin B2 and Zhibai-Dihuang Wan.

ObjectiveTo summarize the clinical features of adult patients with abdominal type Henoch Scholein Purpura(HSP) to improve the early diagnosis and therapeutic outcome of HSP.Methods The clinical features of 31 adult patients with abdominal type HSP from the Hematology department of Handan First Hospital between March 2007 to June 2010 were retrospectively reviewed and compared with that of 30 adult patients with non-abdominal type HSP.Results All the 31 patients had abdominal pain.Of those patients,48.4％ had periumbilical colicky pain, 38.7％ had whole abdominal pain and 12.9％ had lower abdominal pain.The other clinical manifestations included nausea/vomiting(19.4％),positive feces occult blood test(45.1％) .EGD and Colonoscopy of 13 patients showed mucosal congestion, red macda, erosion and ulceration mainly in the descending duodenum, distal ileum and rectosigmoid.There was no difference in age, gender, allergic history and predisposing infection between those with abdominal pain and without.The patients with abdominal pain had more cases of mixed-type HSP than those without and the difference was significant (P ＜ 0.01) .Conclusion Patients with abdominal-type of HSP are mainly young adults.So we must be more alert to abdominal-type of HSP when facing young patients with abdominal emergency.Abdominal-pain-manifesting HSP patients are mostly mixed-type cases.Gastrointestinal endoscopy is specific and might provide valuable clues for early diagnosis.

MicroRNAs and hypoxia inducible factor have extensive and important biological functions, both of them play an important regulatory role in angiogenesis. The interaction between them has an important significance for the profound understanding of the regulatory mechanism of angiogenesis. This article mainly summarizes the mutual regulation of microRNA and hypoxia inducible factor and its effect on angiogenesis in recent years.

Neurogenesis refers to a biological process of neural stem cells self-proliferate and differentiate into new neurons, and are integrated into the neural networks, including the embryonic neurogenesis and adult neurogenesis. Studies have suggested that microRNAs (miRNAs) play vital regulatory roles in neurogenesis. This article reviews the molecular mechanisms of miRNAs in the regulation of embryonic and adult neurogenesis as well as the possible regulatory roles of miRNAs in the process of neurogenesis after cerebral ischemia.

Endothelial progenitor cells(EPCs)are the precursor cells of vascular endothelial cells.EPCs are in bone marrow,peripheral blood and cord blood.They participate in the process of angiogenesis after birth.The stimulation of exogenous and endogenous factors mobilizes bone marrow-derived EPCs into peripheral blood,and participates in the revascularization of ischemic tissue and the process of re-endothelialization of the injured blood vessels.The decreased mmahers and quality of EPCs in blood circulation are one of the most important factors of unfavourable prognosis after ischemic stroke.The transplantation of EPCs may provide a novel therapeutic strategy for the treatment of ischemic cerebrovascular disease.

Induced pluripotent stem (iPS) cells are reprogrammed by the differentiated adult cells, ard in terms of biological characteristics they are remarkably similar to embryonic stem cells. Compared to the embryonic stem cells, the iPS cells are unrestricted by cell resources, immune rejection and ethics, They maintain the advantages such as specific individual genes, and provide potential cell resources for the fields of regenerative medicine and tissue engineering, This article mainly introduces the iPS cells and their application in the research and treatment of cerebrovascular diseases.

Angiogenesis is a vital biological process. MicroRNAs play important regulatory effects in angiogenesis, and the related research has attracted wide attentioa This article summarizes the latest advances in the regulatory effects of microRNAs in vasculogenesis in recent years, and at the same time, sums up some specific microRNAs in angiogenesis that may have imolved in regulating ischemic diseases.