1.Research in operating room nursing technology level-division admittance management system
Ronghuo WU ; Dan ZHU ; Zhicong ZHU
Chinese Journal of Practical Nursing 2011;27(33):7-11
Objective To construct the operating room nursing technology level-division admittance management system.Methods Adopting on-the-spot investigation,iterature research method and expert consultation method to construct the operating room nursing technology level-division admittance management system.Results The enthusiasm coefficient of selected experts was 94.7%,the average authority coefficient was 0.85,six types including 23 items of operating room nursing technology were established.The average difficulty value of this index was 5.36,the highest average difficulty value of class A surgery was 8.25,while the lowest environmental assessment of surgery was 3.21.According to the degree of difficulty,the operating room nursing technology was divided into three classes,the personnel qualifications,training content and capacity requirements of each categories of surgery was confirmed through expert consultation.Conclusions The establishment of the operating room nursing management system can enrich the connotation of operating room nursing technology,increase the nursing safety of the operating room and provide reference basis for admittance management system.At the same time,it can speed up the professionalization process of operating room nursing.
2.Mechanisms of Shexiang Baoxin Pill in homo-therapy for heteropathy in type 2 diabetes mellitus and coronary heart disease based on network pharmacology
Zifan ZHU ; Zhicong WANG ; Bin XIE ; Runhui LIU
Journal of Pharmaceutical Practice and Service 2024;42(4):173-180
Objective To probe into the mechanism of Shexiang Baoxin Pill in homo-therapy for heteropathy for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) based on network pharmacology. Methods All chemical components and action targets of these seven traditional Chinese medical in Shexiang Baoxin Pill were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Traditional Chinese Medicines Integrated Database (TCMID), The Encyclopedia of Traditional Chinese Medicine (ETCM) and BATMAN-TCM platform, and the DisGeNET and GeneCards databases were used to obtain CHD and T2DM-related Disease targets. The “drug-component-target” network map was constructed by Cytoscape 3.8.2 software, the protein-protein interaction (PPI) network map was constructed by STRING database, and the GO biological process analysis and KEGG pathway enrichment analysis were performed on the common targets of Shexiang Baoxin Pill for T2DM and CHD using DAVID online database. Results A total of 101 potential active ingredients for the treatment of T2DM and CHD in Shexiang Baoxin Pill were screened out, corresponding to 229 targets. Network analysis results showed that the common main active ingredients in Shexiang Baoxin Pill for treating T2DM and CHD might be chenodeoxycholic acid, ursodeoxycholic acid, cinnamic aldehyde, bile acids, cinnamic acid, and ginsenosides. The results of pathway enrichment analysis showed that the mechanism of action of Shexiang Baoxin Pill in the treatment of type 2 diabetes and coronary heart disease in treating T2DM and CHD might be related to the inhibition of inflammatory response and oxidative stress. Conclusion Shexiang Baoxin Pill could play a role in treating CHD and T2DM through multiple components, multiple targets and multiple pathways, which provided a certain theoretical basis for the clinical application and further research of Shexiang Baoxin Pill.