Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.

Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(?~(2)=10.94,P

Objective To clarify the frequency, the routes of transmission from mother to infant, the correlation factors and distribution of genotypes of transfusion transmitted virus (TTV) infection. Methods Nested polymerase chain reaction (n PCR) was performed to detect TTV DNA and genotypes in serums and breast milks from 160 cases of pregnant women. Results TTV DNA in serum and breast milk was detected in 64 (40 0%) and 60 (37 5%) of 160 cases of pregnant women respectively. The positive rates of TTV DNA from HBV markers (+) and normal groups were 50 0%, 43 1% and 13 6%, 22 7% respectively in serums and breast milk. There were significant difference between the two groups ( P

Face ; blood supply ; Hemangioma ; therapy ; Humans ; Vascular Malformations ; therapy ; Vasculitis ; therapy

Enterocolitis, Necrotizing ; diagnostic imaging ; Humans ; Infant, Newborn ; Male ; Radiography

Face ; blood supply ; Hemangioma ; classification ; diagnosis ; therapy ; Humans ; Jaw ; blood supply ; Lymphatic Abnormalities ; classification ; diagnosis ; therapy ; Mouth ; blood supply ; Vascular Malformations ; classification ; diagnosis ; therapy

Hepatitis C, Chronic ; etiology ; pathology ; therapy ; Humans ; Recurrence

The post-operative adjuvant chemotherapy(PAC) for non-small cell lung cancer(NSCLC) appeared on the 1970s of the 20th century. Along with the appearance of each kind of new drugs and new combined therapeutic regimen, PAC for NSCLC is also progressed gradually, and more and more evidence showed that PAC can improve the survival and quality of life of patients with NSCLC. The present situation of PAC for NSCLC and the prospects of its future development were introduced.

Objective To explore the relationship between the ST-T continuous changes of ECG and the chronic coronary insufficiency.Methods 158 cases of ST-T continuous changes of ECG were treated with selective plate exercise tests and the coronary arteriography.Results 54 cases of plate exercise tests were positive(34.2%),104 cases were negative(65.8%).36 cases were diagnosed as the stenosis of coronary through the coronary arteriography(22.7%).But among 54 positive cases of plate exercise tests,33 cases had the stenosis of coronary,accounting for 91.6% in the cases of stenosis of coronary.Conclusion The quiescent ECG ST-T continuous changes aren't specfic changes of chronic myocardial ischemia.Most of them are caused by other reasons.

Objective To study the nutrition status of premature infants in the early postnatal stage.Methods According to the physical development standard,the premature neonates for treatment in our NICU from Jun.2007 to Jun.2009 were enrolled and divided into normal growth group and extrauterine growth restriction(EUGR) group.The nutrition status of these premature neonates were evaluated respectively.SPSS 13.0 software was used to analyze the data.Results Compared with EUGR group,the durations of regaining birth weight were shorter in normal growth group(t=-13.83,P0.05).Conclusions Premature neonates are prone to encounter extrauterine growth retardation.Extrauterine growth retardation had great impact on premature neonates.Premature neonates should be strengthened with nutrition supplement in order to reduce the incidence of extrauterine growth retardation.