Objective To investigate the clinical effects of posterior reduction and interbody fusion in the treatment of thoracolumbar fractures and dislocations ,and its impact on the neural function .Methods 12 cases with thoracolumbar fractures and dislocations were treated with posterior reduction and interbody fusion .After treatment , flange height ,Cobb angle ,nerve function ,complications of internal fixation were observed ,and the clinical efficacy was evaluated.Results The anterior height of fractured vertebrae was significantly increased from (56.7 ±7.9)% to (90.4 ±9.8)% in 12 patients(t=9.3,P<0.05);Cobb angle was significantly reduced from (28.4 ±3.8)°to (7.9 ±2.9)°(t=14.9,P<0.05);The grade of neural function was obviously improved (from 2 cases A,5 cases B, 4 cases C and 1 case D to 1 case A,1 case B,2 cases C,6 cases D and 2 cases E),and there were no serious compli-cations.Conclusion The clinical effect of posterior reduction and interbody fusion in the treatment of thoracolumbar fractures and dislocations was good ,which is worthy of clinical application .

Fracture Fixation ; methods ; trends ; Fractures, Bone ; surgery ; Humans ; Pelvic Bones ; injuries ; surgery

Objective To explore the efficacy of different modes of fluid resuscitation (early or delayed use of norepinephrine) on lung injury of septic shock rat induced by LPS.Methods A total of 60 male Wistar rats were randomly (random number) divided into 4 groups:the normal control group (group A,n =15),septic shock control group (group B,n =15),conventional fluid resuscitation group (group C,n =15),fluid resuscitation with early using of norepinephrine group (group D,n =15).All rats were mechanically ventilated with the same parameters.In the group C,norepinephrine was used 30 min after fluid resuscitation.In the group D,norepinephrine was used at the beginning of fluid resuscitation.Vital signs,volume of fluid infused and dosage of norepinephrine were recorded.Rats were sacrificed 2 h later and blood samples were collected for blood gas analysis.The lung tissues and BALF were collected.Pathological changes of the lung tissues were observed under light microscope.The levels of MPO,SOD and MDA were detected.The levels of IL-6,IL-8 and TNF-α in BALF and in serum were detected by using ELISA.Results Compared with group C,the mean volume of fluid infusion to achieve target blood pressure was decreased,oxygenation index was improved and the level of blood lactic acid were decreased in group D (P ＜ 0.05).HE staining indicated that inflammatory cells were decreased,pulmonary edema and alveolar walls hyperemia were alleviated in group D in comparison with group C.Inflammatory cytokines (IL-6,IL-8 and TNF-α) in BALF and in serum were significantly decreased in group D compared with group C (P ＜0.05).Levels of MPO were decreased in group D compared with group B and group C.However,early using of norepinephrine had limited effect on the levels of SOD and MDA.Conclusions The current study demonstrated that fluid resuscitation with early use of norepinephrine exhibited a protective effect on lung injuries induced by LPS.

To introduction the biological function of vascular endothelial growth factor and to explore the role of vascular endothelial growth factor(VEGF)and in the pathogenesis of endotoxin,ischemia-reperfusion,hyperoxia,ventilator-induced lung injury(ALI)/acute respiratory distress(ARDS).

OBJECTIVE: To establish a method for simultaneous determination of the contents of muilti-constituents in tall gastrodia capsules for quality control. METHODS: The HPLC was performed on a Phenomenex Hydro-RP 80A (4.6 mm × 150 mm, 4 μm) column with a mixture of methanol-0.1% H3PO4 solution as the mobile phase in a linear gradient elution mode. The flow rate was 1 mL · min-1, and the column temperature was set at 40 Tl. The detection wave length was set at 270 nm. RESULTS: The linear ranges were 0.40 - 6.4 μg (r = 0.9997) for gastrodin, 0.064 - 1.0 μg(r = 0.9998) for 4-hydroxybenzyl alcohol, 0.020 - 0.32 μg (r =0.9997) for 4-hydroxybenzaldehyde, 0.60-9.5 μg (r = 0.9999) for parishin, respectively. The average recovery were 100.8% (RSD 2.3%), 100.5% (RSD 3.4%), 101.9% (RSD 2.1%), 100.4% (RSD 2.5%), respectively. Six constituents were determined. The average content of the 6 constituents of 25 samples were 2.189% (RSD 3.40%). CONCLUSION: The method is reliable and can be used for the quality evaluation of tall gastrodia capsules. Copyright 2012 by the Chinese Pharmaceutical Association.

Objective To summarize the clinical characteristics of foreign accent syndrome (FAS) among Chinese. Methods The journal articles published in Chinese between 1980 and 2011 were retrieved with three Chinese translated versions of FAS as the key words, and 38 articles in line with the inclusion criteria were systematically analyzed. Results and Conclusion Each year, about (3.06±1.65) cases were published on FAS ever since 1996. The age of FAS patients was averagely around 38.10 years, and of the reported cases, there were 26 males and 23 females, there is no significant difference in gender (χ2=0.184, P=0.668). The etiological factors of FAS were identified mainly as injury (59.19%), stroke (32.65%) and psychogenic disorder (8.16%), and 65.31% of the focus were found at the left side of brain.85.72 % of the FAS patients were seen to be speaking a new dialect used by a larger population. 80% of the patients who didn't suffer from a coma changed their accent in 72 h following the injury, while 72.73% of those once in a coma changed their accent as they gained consciousness.The prognosis of FAS was fine, with an improvement rate of 70.83%, and 73.53 % of the patients began to recover less than 3 months later following the injury.

Compared with hip replacement, internal fixation in the treatment of the elderly femoral neck fracture, especially the application of cannulated screws, is minimally invasive, easy to operate and economical. In recent years, it becomes the research focus in the field of orthopedic clinical research. However, configuration of cannulated screws is still controversial. Most clinicians believe that three cannulated screws being placed in parallel in an inverted triangle configuration is better than that in a triangular configuration in biomechanics and clinical effect. Nonparallel strong oblique nailing technique allows the screws to share more weight to reduce postoperative complications, so that it is more suitable for elderly patients with osteoporosis. However, the related complications of internal fixation such as nonunion, femoral neck shortening and other problems are still the focus of domestic and foreign scholars. Issues about how to control the indication of internal fixation surgery, understand related factors of the complications, and prevent complications are required to be further explored.
Aged ; Bone Nails ; Femoral Neck Fractures ; surgery ; Fracture Fixation, Internal ; adverse effects ; methods ; Humans ; Internal Fixators

Objective To observe the physiopathologic changes of lung in rats with acute ischemic kidney injury,and to study the roles of cytokine,epithelial sodium channel protein (ENaC) and aquaporin 1 (AQP1) in acute lung injury brought on by acute ischemic kidney injury in rats.Methods A total of 60 healthy male Wistar rats (300-320 g) were randomly (random number) divided into control groups (group A,n =30) and acute kidney injury group (group B,n =30).The model of acute ischemic kidney injury in rats was made by bilateral renal arteiovenous blockage with clamps.Six rats of each group were sacrificed at 0,2,4,6 and 8 hours after modeling.Lung tissue of rats was harvested and stained with hematoxylin-eosin (HE) staining method,and the pathological changes of lung were observed under microscope.The ratio of wet and dry weight (W/D) of lung was calculated.The levels of protein in bronchoalveolar lavage fluid (BALF) were measured.The levels of IL-6 and TNF-α both in serum and BALF were tested.The concentrations of AQP1 and α-ENaC in lung were measured.Results At six hours after modeling,the pH value of arterial blood of rats in group B began to get lowered compared to group A.There was no difference in partial pressure of oxygen in arterial blood between two groups during entire period of experiment (P ＞0.05).Protein level in BALF and W/D of lung increased significantly two hours after modeling in rats of group B (P ＜ 0.05).The histopathological changes of acute lung injury including swollen aleolar epithelium,widened interalveolar septum,edema of alveoli and alveolar interstitium,alveolar neurophil sequestration,erythrocytes and protein in exudates were observed.The levels of TNF-α and IL-6 in serum and in BALF began to increase at two hours after modeling.The levels of AQP1 and α-ENaC of lung in rats with acute kidney injury decreased gradually and were lower than those in rats of group A (P ＜0.05).Conclusions Aleolar epithelial-endothelial barrier function was already compromised at the beginning of AKI,suggesting the acute lung injury was already brought on.The levels of TNF-α,IL-6 in serum and in BALF increased after the occurrence of acute kidney injury.The decreases in lung AQP1 and α-ENaC might contribute to the lung injury caused by early acute kidney injury.

Objective To compare the regulatory functions of Danhong and Salvia Ligustrazin on abnormal coagulation factors Ⅶ caused by ACS.Methods All cases were randomly divided into group A and B and a control group.Each group contains 60 patients.The control group was treated with conventional western therapies.On this basis,group A Was treated with Danhong injection and group B was treatedwith Salvia Ligustrazin injection.Compare the regulatory function of its group on abnormal level of coagulation factor Ⅶ caused by ACS.Results Group B showed better effects in its regulating abnormal level of coagulation factor Ⅶ as compaared to group A(χ~2=3.67,P＜0.05).Both groups did better than the control group in adjusting coagulation factors Ⅶ (P＜0.05).Conclusion Salvia ligustrazine has better effect in regulating coagulation factors Ⅶ than Dan Hong injection,which is better than conventional western medical therapy.

[Objective] Analyze the academic thought ofpurge stomach and tonify spleentreatment used by Professor SUN Zhi in acupuncture on type-2 diabetes mellitus during his clinical experience.[Method] According to new recognition of type-2 diabetes mellitus pathogenesis, study of acupuncture theory, clinical manipulation, conclude acupuncture point choices and needling methods ofpurge stomach and tonify spleentreatment, studying its characteristics. [Result] Type-2 diabetes mellitus belonging toXiaokecategory which features excessive discharge of urine and persistent thirst in Chinese medicine, but their pathogenesis is not the same, Professor SUN Zhi based on years of clinical observation found that patients with type-2 diabetes mellitus commonly manifested obese, polyorexia and accompanied by fatigue, summarized asstrong stomach and weak spleen. Tonify the deficiency and purge sthenia, using acupuncture manipulation, regulating spleen and stomach function, by reducing method of acupuncture Zhongwan, Zusanli and Neiting to inhibt stomach and control appetite, reinforcing method of acupuncture Sanyinjiao, Taibai, Pishu to enhance the transport of the spleen, meaning purging stomach and tonifying spleen. This treatment of type-2 diabetes mellitus in clinic achieved good results. [Conclusion]Purge stomach and tonify spleentreatment offers a new way of acupuncture to treat diabetes, deserving further exploration, popularization and application.