2.Development and research advances of iridoids from Valeriana jatamansi and their bioactivity.
Ning-ning ZHANG ; Guang-zhi DING
China Journal of Chinese Materia Medica 2015;40(10):1893-1897
Valeriana jatamansi (syn. V. wallichii), a traditional Chinese medicine recorded in Chinese Pharmacopeia (1977 and 2010 edition), has been used for treatment of a variety of conditions including sleep problems, obesity, nervous disorders, epilepsy, insanity, snake poisoning, eye trouble, and skin diseases. Also, it was used as an important substitute for the European V. officinalis, whose root preparation, popularly known as valerian, has been employed as a mild sedative for a long time. In recent years, much attention has been draw to the iridoids, one of the major bioactive constituents of V. jatamansi, leading to the discovery of a series of new iridoids with anti-tumor and neuroprotective activities. Their action machnism also has been discussed. This paper summerized the iridoids and their bioactivities from V. jatamansi in recent years, which could provide basic foundation for development and research of V. jatamansi.
Animals
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Drugs, Chinese Herbal
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chemistry
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pharmacology
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Humans
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Iridoids
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chemistry
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pharmacology
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Valerian
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chemistry
4.Reappraisal of invasive lobular carcinoma.
Chinese Journal of Pathology 2009;38(6):363-365
Breast Neoplasms
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epidemiology
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metabolism
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pathology
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Cadherins
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metabolism
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Carcinoma, Lobular
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epidemiology
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metabolism
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pathology
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Catenins
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metabolism
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Diagnosis, Differential
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Female
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Humans
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Keratins
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metabolism
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Lymphoma
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metabolism
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pathology
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Mastitis
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metabolism
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pathology
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Plasmacytoma
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metabolism
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pathology
5.The Acting Mechanisms of Statins and Their Application in the Prevention and Treatment of Stroke
Ding-Ming SUN ; Zhi-Jun ZHANG ;
International Journal of Cerebrovascular Diseases 2006;0(10):-
Stroke is one of the most important causes of disability throughout the world.Epide- miological and clinical studies have demonstrated that statins significantly decrease the incidence of ischemic stroke.In addition to lipid-lowering effect,statins may also have a number of other acting mechanisms that are not dependent on reducing cholesterol levels.Moreover,statins inhibit cerebral vasospasm caused by subarachnoid hemorrhage.For most of the individuals,the safety and tolerability of statins are well.
6.Relationship between carotid atherosclerotic plaque and its related factors and cerebral infarction
Dong CHEN ; Rui ZHI ; Chaobing DING
Journal of Clinical Neurology 1997;0(06):-
Objective To investigate the relationship between carotid atherosclerosis(CAS)plaque and its related factors and cerebral infarction(CI).Methods The 91 patients with CI were detected by Color Doppler and the levels of plasma lipid,blood glucose(BG)and fibrinogen(Fbg)were evaluated,and compared with normal control(NC)group.Results(1)Compare with NC group,the IMT,prevalence of CAS plaque,the rates of soft plaque in CI group were significantly higher(all P
7.Furosemide Test Predicts Hematoma Enlargement in Patients of Hypertensive Cerebral Hemorrhage
Rui ZHI ; Dong CHEN ; Chao-Bing DING ;
Chinese Journal of Hypertension 2006;0(09):-
Objective To study the validity of furosemide test for predicting the hematoma enlargement in pa- tients with hypertensive cerebral hemorrhage.Methods Four hundred fifty-one patients with hypertensive cerebral hemorrhage were diagnosed using CT after oneset of the disease and 24 h reexamined 24 h after.The incidence of enlarged hematoma was evaluated by comparison the baseline and 24 h CT scanning.Furosemide(20 mg iv)was ad- ministered and blood pressure was measured 30 min after furosemide.Results The decreasing level of MAP after furosemide was significantly inversely related with incidence rate of hematoma enlargement{ r=-0.94,t=58.4,P 10 mmHg as the cut-off point,with the rate of hematoma enlargement as being 6.4 %,MAP decreased≤10 mmHg was associated with increases in prevalence of hematome to 33.2 %(?~2=51.82, P
8.Spectral analysis of nearly 5 years of infectious diseases in a hospital of Chongqing city
Jing DING ; Wenguang TIAN ; Shiwei WANG ; Zhi ZHOU
Chongqing Medicine 2014;(24):3206-3209
Objective To understand epidemic data and provide evidence for prevention and control of infectious diseases in Yongchuan area .Methods We collected the clinical materials of patients hospitalized during January 2008 to December 2012 ,and retrospectively analyzed the spectrum ,classification and epidemic tendency of infectious diseases in a hospital .Results A total of 4 632 patients were admitted to the department of infectious disease .The top two diseases were always hepatitis B virus infection related diseases and tuberculosis .Fatality mainly also appeared in end-stage liver diseases and tuberculosis .Morbidity of measles and mumps increased obviously in recent years .Hand-foot-mouth disease and influenza A(H1N1) were epidemic in this area .Conclusion The main infectious diseases in Yongchuan area are hepatitis B virus infection related diseases and tuberculosis ,which still are the important points for control and prevention .Also we should strengthen prevention of other infectious diseases such as hand-foot-mouth disease ,H1N1 and the mumps in order to decrease the occurrence of these infectious diseases .
9.Selenium-enriched Spirulina platensis promotes proliferation of hepatocytes in rat partial hepatectomy
Feng HUANG ; Zhi HUANG ; Wenjie ZHENG ; Fang YANG ; Zihai DING
Chinese Journal of Pathophysiology 1989;0(05):-
AIM: To explore the effects of selenium-enriched Spirulina platensis (Se-SP) on proliferation of hepatocytes in rat hepatectomy. METHODS: Rat hepaectomy model was conducted using male Wistar rats. The rats were randomized into five groups: operation groups with 150 (H), 50 (M) and 15 (L) mg?kg-1?d-1 of Se-SP, placebo-control (P) and sham operation group (F). Activities of glutathione peroxidase (GPx) and thioredoxin reductases (TR) in hepatocytes were determined by chemical colorimetry. The expression index of proliferating cell nuclear antigen (PCNA) in hepatocytes was detected by immunohistochemistry, and the level of [3H]-TDR incorporation in regenerative hepatocytes was analyzed by radio-immunity. RESULTS: Activity of GPx and TR, PCNA expression index as well as [3H]-TDR insertion in hepatocytes (in vitro) were obviously higher (P
10.Discriptive systematic review for the application of problem-based learning in education of health service management
Ying MA ; Jie SHI ; Run ZHOU ; Zhi HU ; Hong DING
Chinese Journal of Medical Education Research 2017;16(1):22-27
Objective To systematically evaluate the application of problem-based learning (PBL)in the teaching process of health management major in China.Methods Databases including CNKI (1979 to December the 2015),VIP (1989 to December the 2015),Wanfang (1982 to December the 2015) and PubMed were systematically retrieved.Any literature about PBL of health management major was included.Seffdeveloped data extraction form was used for collecting the information.Data were input and analyzed using Excel 2007.Results 15 papers were included in the analysis.The first author mainly came from the northeast region of China (7).Most (10) papers did not get the funding support.No paper was published in the journals contained in the Guide to the Core Journals of China.6 papers of experimental studies compared the performance difference of students of the PBL and lecture-based learning (LBL),which was statistically significant.Conclusion PBL is superior to the LBL.However,due to the large difference in the quality of literature,more studies were needed to determine the effect of PBL.Moreover,we should pay attention to the combination of PBL and LBL.