Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.

China ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health ; legislation & jurisprudence ; Occupational Health Services ; organization & administration ; standards

OBJECTIVE: To evaluate the in vitro and in vivo antibacterial activities of cefodizime from both home and abroad. METHODS: The minimal inhibitory concentrations (MICs) of domestic and imported cefodizime, cefotaxime sodium against 300 clinical isolates of bacteria were tested by standard agar dilution method and the test tube dilution method. The in vivo antibacterial activities of cefodizime were determined in mice with experimental systemic infection caused by E.coli, K. pneumoniae and S.aureus. The values of ED50 were calculated by Bliss method. RESULTS: Both domestic and imported cefodizime had remarkable potency against majority gram- negative bacteria and gram- positive bacteria, including pneumococcus and beta streptococcus, and the MIC90 of cefodizime stood at 0.012～1.0?g?mL-1; and they showed medium grade antibacterial activity against bacillus cloacae, bacillus aerogenes and serratia but mild effects on MSSA and S.epidermidis, and the MIC50 stood at 4?g?mL-1. In this trial, bacillus aeruginosus, acinetobacter, enterococcus and MRSA showed resistance against the domestic and imported cefodizime. The in vivo antibacterial activities of domestic and imported cefodizime were similar and remarkable in mice infected with E.coli, K.pneumoniae and S.aureus. CONCLUSION: Domestic and imported cefodizime had excellent and similar antibacterial activity.

The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer,the pediatric cancer retinoblastoma.As a negative regulator of the cell cycle,RB1 gene could regulate the expression of genes involved in cell proliferation through binding to transcription factor E2F.A-mong these,RB1 has been implicated in the regulation of apoptosis.RB1 knockdown has been shown to enhance the sensitivity to cell death induced by different anticancer agents.RB1 dual role in proliferation and apoptosis un-derlies malignant tumor occurrence,development and resistance totherapy.

Objective To investigate the clinical effect of implantable collamer lens ( ICL) in the treatment of super high myopia. Methods 20 patients with high myopia were given ICL,and changes in patients with visual acuity,intraocular pressure and corneal endothe-lial cells,and surgery-related complications and outcome were observed. Results Before surgery,the visual acuity of patients was (0. 10±0. 05),and postoperative (0. 60±0. 20),the difference was statistical significance(P<0. 05);the intraocular pressure and corneal endothe-lial cells of patients did not change significantly after surgery,with less postoperative complications. Conclusion The ICL has a very signifi-cant effect in the treatment of super high myopia,which can help to improve the patient's quality of life,and it is worthy of wide promotion and application.

Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.

Objective To explore the differential effects of stroke localization on autonomic function parameters assessed by HRV and study the circadian fluctuation of HRV in the acute phase of ischemic stroke.Methods Components of HRV were obtained twice from patients in acute stroke(5d and 4w) in 68 cases and 50 age-and sex-matched health control subjects.Cerebral CT or MRI verified hemispheric brain infarction and.Results(1) In the acute phase of ischemic stroke(5d) all components of heart rate variability had significantly decreased P

Acute kidney injury(AKI) can lead to remote organ damage.The specific mechanism by which the AKI results in distant organ damage is yet to be determined.In animal models,it has become increasingly clear that AKI is not an isolated event but results in remote organ dysfunction involving the heart,lungs,liver,and brain.This review summarizes the effects of AKI on remote organs.

Objective To compare the clinical value of automatic coagulometer and automatic biochemistry analyzer for the de-tection of antithrombin Ⅲ(AT-Ⅲ)in acute myocardial infarction and cirrhosis.Methods 55 cases of acute myocardial infarction and cirrhosis patients were investigated in the study,the healthy people was normal control.The concentration of AT-Ⅲwas detec-ted with automatic coagulometer and automatic biochemistry analyzer at the same time.Results The concentration of AT-Ⅲ detec-ted with automatic coagulometer was (251.2±58.5 )mg/L,(228.0 ±22.6)mg/L in acute myocardial infarction and cirrhosis pa-tients,the concentration of AT-Ⅲ detected with automatic biochemistry analysis was (255.6±54.3)mg/L,(230.3±23.1)mg/L in acute myocardial infarction and cirrhosis patients,and the concentration of AT-Ⅲwas significantly lower than that in normal control (P <0.05).The concentration of AT-Ⅲ detected with two detection methods in acute myocardial infarction patients was signifi-cantly lower than that in cirrhosis patients(P <0.05).There were significant difference between automatic coagulometer and auto-matic biochemistry analyzer for the detection of antithrombin Ⅲ(AT-Ⅲ).Conclusion The detection of AT-Ⅲ with automatic coag-ulometer and automatic biochemistry analyzer could diagnose and identify acute myocardial infarction and cirrhosis.

miR-10a,as one member of miRNA family,belongs to the fannily of miR-10.It locates between HOXB4 and HOXB5 genes on the short arm of chromosome 17.miR-10a is abnormal expressed in a variety of human tumors and is closely related to the occurrence,development and prognosis of tumor.The relationship of miR-10a with a variety of tumors is reviewed in this paper.