Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.

Objective To investigate the clinical effects of posterior reduction and interbody fusion in the treatment of thoracolumbar fractures and dislocations ,and its impact on the neural function .Methods 12 cases with thoracolumbar fractures and dislocations were treated with posterior reduction and interbody fusion .After treatment , flange height ,Cobb angle ,nerve function ,complications of internal fixation were observed ,and the clinical efficacy was evaluated.Results The anterior height of fractured vertebrae was significantly increased from (56.7 ±7.9)% to (90.4 ±9.8)% in 12 patients(t=9.3,P<0.05);Cobb angle was significantly reduced from (28.4 ±3.8)°to (7.9 ±2.9)°(t=14.9,P<0.05);The grade of neural function was obviously improved (from 2 cases A,5 cases B, 4 cases C and 1 case D to 1 case A,1 case B,2 cases C,6 cases D and 2 cases E),and there were no serious compli-cations.Conclusion The clinical effect of posterior reduction and interbody fusion in the treatment of thoracolumbar fractures and dislocations was good ,which is worthy of clinical application .

Objective:To investigate the method for treating facial post-burn hyperpigmentation. Methods: Forty-two patients with facial post-burn hyperpigmentation were randomly divided into two groups.Twenty-four subjects applied 15% Azelaic Acid cream combined with 0.025% Tretinoin cream daily to face,and eighteen subjects applied vehicle cream.At base line and six weeks of treatment,each subject's facial hyperpigmentation was assessed by area and colorimetric evaluations.Results:The facial post-burn hyperpigmentation of the Azelaic Acid and Tretinoin-treated subjects were significantly lighter after six weeks of therapy than those of the vehicle-treated subjects(?~(2)=10.94,P

Systems Biology including Systems Biomedicine is emerging internationally and providing opportunities for revolutions of Traditional Chinese Medicine (TCM) and conventional western drugs (WD), while the latter has been taking more advantages because WD has much stronger research basis at molecular levels than TCM. Thorough understanding of molecular network including gene network would automatically induces design of WD into formula western drugs equipped with TCM philosophy, but such molecular formula drug is eventually one of the final aims of modernization of TCM. So TCM is facing big threats it never met. This situation requires a nationwide and international strategy with intelligence and resolution.

To embark on a standard,systematic and legal metrology work in grassroots medical units,it is recommended that the position of a full-time gauger should be set and more effort should be put into publicity and supervision of metrology law,which is an indispensable part of equipment management.[Chinese Medical Equipment Journal,2008,29(2):108-109]

Mycoplasma pneumoniae(MP) is a common pathogen of community-acquired pneumonia in children.In recent years,with increase in the incidence of MP infection,the severe cases caused by the later pathogen are also incresing.At present the pathogenesis of severe Mycoplasma pneumoniae pneumonia(SMPP) is still not very explicit,and increased macrolide resistance of MP made a great impact on the treatment.This article reviewed the recent progress in the study of the pathogenesis,clinical manifestations,diagnosis and treatment of SMPP.

Objective To explore the feasibility of conservative treatment in patients with ectopic pregnancy.Methods The clinical data of 38 cases of ectopic pregnancy treated with conservative treatment were retrospectively analyzed.Results All the 38 patients with ectopic pregnancies were treated with MTX single dosage.There were 7 patients who failed in the conservative treatment and the rest of which were successfully cured.Conclusion For those early diagnosis and strictly selected ectopic pregnancy patients .conservative drug treatment is safe and effective.

Objective To compare the clinical value of automatic coagulometer and automatic biochemistry analyzer for the de-tection of antithrombin Ⅲ(AT-Ⅲ)in acute myocardial infarction and cirrhosis.Methods 55 cases of acute myocardial infarction and cirrhosis patients were investigated in the study,the healthy people was normal control.The concentration of AT-Ⅲwas detec-ted with automatic coagulometer and automatic biochemistry analyzer at the same time.Results The concentration of AT-Ⅲ detec-ted with automatic coagulometer was (251.2±58.5 )mg/L,(228.0 ±22.6)mg/L in acute myocardial infarction and cirrhosis pa-tients,the concentration of AT-Ⅲ detected with automatic biochemistry analysis was (255.6±54.3)mg/L,(230.3±23.1)mg/L in acute myocardial infarction and cirrhosis patients,and the concentration of AT-Ⅲwas significantly lower than that in normal control (P <0.05).The concentration of AT-Ⅲ detected with two detection methods in acute myocardial infarction patients was signifi-cantly lower than that in cirrhosis patients(P <0.05).There were significant difference between automatic coagulometer and auto-matic biochemistry analyzer for the detection of antithrombin Ⅲ(AT-Ⅲ).Conclusion The detection of AT-Ⅲ with automatic coag-ulometer and automatic biochemistry analyzer could diagnose and identify acute myocardial infarction and cirrhosis.

Objective To compare the clinical effect of three Endobutton plates and clavicular hook plate in treatment of acromioclavicular joint dislocation.Methods Forty-two patients with acromioclavicular joint dislocation were randomly divided into EB group (20 patients) who were treated with three Endobutton plates and CH group (22 patients) who were treated with clavicular hook plate from January 2008 to January 2011.Perioperative index (operation time,blood loss and VAS scores on the third day postoperatively),Karlsson shoulder joint function scores and postoperative complication were compared.Results The operation time and blood loss in EB group were significantly higher than those in CH group [(113.6 ± 25.3)minvs.(62.3±17.8)min,(152.7±15.2) mlvs.(93.1±18.9)ml,P＜0.O5].However,therehadno significant difference for VAS scores on the third day postoperatively between two groups (P ＞ 0.05).EB group was superior to CH group for shoulder joint function scores on the twelfth month postoperatively,but there had no significant difference [95.0％ (19/20) vs.81.8％ (18/22),P ＞ 0.05].The incidence rate of shoulder joint pain and stiffness in EB group were significant lower than those in CH group[20.0 ％ (4/20) vs.50.0％(11/22),20.0％(4/20) vs.54.5％(12/22),P ＜ 0.05].The incidence rate of incision infection in two groups had no significant difference (P ＞ 0.05).Conclusions Compared with clavicular hook plate,three Endobutton plates fixation is complex and consequently with more blood loss.However,three Endobutton plates fixation have advantage in clinical effect and complication.

Acute kidney injury(AKI) can lead to remote organ damage.The specific mechanism by which the AKI results in distant organ damage is yet to be determined.In animal models,it has become increasingly clear that AKI is not an isolated event but results in remote organ dysfunction involving the heart,lungs,liver,and brain.This review summarizes the effects of AKI on remote organs.