Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.

China ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health ; legislation & jurisprudence ; Occupational Health Services ; organization & administration ; standards

Fracture Fixation ; methods ; trends ; Fractures, Bone ; surgery ; Humans ; Pelvic Bones ; injuries ; surgery

Objective To compare the clinical effect of three Endobutton plates and clavicular hook plate in treatment of acromioclavicular joint dislocation.Methods Forty-two patients with acromioclavicular joint dislocation were randomly divided into EB group (20 patients) who were treated with three Endobutton plates and CH group (22 patients) who were treated with clavicular hook plate from January 2008 to January 2011.Perioperative index (operation time,blood loss and VAS scores on the third day postoperatively),Karlsson shoulder joint function scores and postoperative complication were compared.Results The operation time and blood loss in EB group were significantly higher than those in CH group [(113.6 ± 25.3)minvs.(62.3±17.8)min,(152.7±15.2) mlvs.(93.1±18.9)ml,P＜0.O5].However,therehadno significant difference for VAS scores on the third day postoperatively between two groups (P ＞ 0.05).EB group was superior to CH group for shoulder joint function scores on the twelfth month postoperatively,but there had no significant difference [95.0％ (19/20) vs.81.8％ (18/22),P ＞ 0.05].The incidence rate of shoulder joint pain and stiffness in EB group were significant lower than those in CH group[20.0 ％ (4/20) vs.50.0％(11/22),20.0％(4/20) vs.54.5％(12/22),P ＜ 0.05].The incidence rate of incision infection in two groups had no significant difference (P ＞ 0.05).Conclusions Compared with clavicular hook plate,three Endobutton plates fixation is complex and consequently with more blood loss.However,three Endobutton plates fixation have advantage in clinical effect and complication.

Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.

Objective To explore the feasibility of conservative treatment in patients with ectopic pregnancy.Methods The clinical data of 38 cases of ectopic pregnancy treated with conservative treatment were retrospectively analyzed.Results All the 38 patients with ectopic pregnancies were treated with MTX single dosage.There were 7 patients who failed in the conservative treatment and the rest of which were successfully cured.Conclusion For those early diagnosis and strictly selected ectopic pregnancy patients .conservative drug treatment is safe and effective.

Acute kidney injury(AKI) can lead to remote organ damage.The specific mechanism by which the AKI results in distant organ damage is yet to be determined.In animal models,it has become increasingly clear that AKI is not an isolated event but results in remote organ dysfunction involving the heart,lungs,liver,and brain.This review summarizes the effects of AKI on remote organs.

Objective: To explore the traditional Chinese medicine (TCM) diagnosis and treatment of type 2 diabetes in Tianjin urban population. Methods: A cross-sectional study was conducted on hospital patients with type 2 diabetes in TCM hospitals of different levels in Tianjin from 2003 to 2007. The multiphasic stratified cluster sampling method was adopted in selecting the target hospital. Finally 3 496 patients were selected as the survey sample. Then the constituent ratios of diabetes in different syndrome types were calculated. Results: In this study, the descending sort proportion of TCM syndrome types of type 2 diabetes in Tianjin urban population was deficiency of both qi and yin, stagnation of phlegm-dampness, exuberant heat due to yin deficiency, deficiency of both yin and yang, and blood stasis and qi stagnation. Most of the diabetes patients with deficiency of both qi and yin, deficiency of both yin and yang, and stagnation of phlegm-dampness were older than 60 years. Most of the diabetes patients with exuberant heat due to yin deficiency were 50 to 59 years old, while the diabetes patients with blood stasis and qi stagnation were 40 to 49 years old. The frequency of Danggui (Angelica sinensis) use was high in the diabetes patients with deficiency of both qi and yin; the frequency of Chenpi (Citrus reticulate Blanco) use was high in the diabetes patients with exuberant heat due to yin deficiency; the frequency of Baishao (Radix Paeoniae Alba) use was high in the diabetes patients with deficiency of both qi and yin; the frequency of Gancao (Radix Glycyrrhizae) use was high in the diabetes patients with stagnation of phlegm-dampness; and the frequency of Xingren (Semen Armeniacae) use was high in the diabetes patients with blood stasis and qi stagnation. Conclusion: The main syndrome types of diabetes patients in Tianjin urban area are deficiency of both qi and yin, stagnation of phlegm-dampness and exuberant heat due to yin deficiency. And the patients are mainly older than 50 years. The most frequently used herbs are Danggui (Angelica sinensis), Chenpi (Citrus reticulate Blanco), Baishao (Radix Paeoniae Alba), Gancao (Radix Glycyrrhizae) and Xingren (Semen Armeniacae).

Objective To compare the clinical value of automatic coagulometer and automatic biochemistry analyzer for the de-tection of antithrombin Ⅲ(AT-Ⅲ)in acute myocardial infarction and cirrhosis.Methods 55 cases of acute myocardial infarction and cirrhosis patients were investigated in the study,the healthy people was normal control.The concentration of AT-Ⅲwas detec-ted with automatic coagulometer and automatic biochemistry analyzer at the same time.Results The concentration of AT-Ⅲ detec-ted with automatic coagulometer was (251.2±58.5 )mg/L,(228.0 ±22.6)mg/L in acute myocardial infarction and cirrhosis pa-tients,the concentration of AT-Ⅲ detected with automatic biochemistry analysis was (255.6±54.3)mg/L,(230.3±23.1)mg/L in acute myocardial infarction and cirrhosis patients,and the concentration of AT-Ⅲwas significantly lower than that in normal control (P <0.05).The concentration of AT-Ⅲ detected with two detection methods in acute myocardial infarction patients was signifi-cantly lower than that in cirrhosis patients(P <0.05).There were significant difference between automatic coagulometer and auto-matic biochemistry analyzer for the detection of antithrombin Ⅲ(AT-Ⅲ).Conclusion The detection of AT-Ⅲ with automatic coag-ulometer and automatic biochemistry analyzer could diagnose and identify acute myocardial infarction and cirrhosis.

OBJECTIVETo compare the difference in clinical efficacy on post-stroke sensory disturbance between catgut implantation at scalp reflecting foci and conventional acupuncture as well as the impacts on blood rheology.

METHODSFifty-nine cases of post-stroke sensory disturbance were randomized into a catgut implantation group (30 cases) and an acupuncture group (29 cases). The conventional internal medicine treatment, limb motor function rehabilitation training and sensory function training were applied in the two groups. Additionally, the catgut implantation was used at scalp reflecting foci in the catgut implantation group, once a week, 4 treatment made one session. In the acupuncture group, acupuncture was applied at Baihui (GV 20), Fengchi (GB 20), Jianyu (LI 15), Quchi (LI 11), Waiguan (TE 5), Hegu (LI 4), Siqiang (EX-LE 24), Yanglingquan (GB 34), Zusanli (ST 36), Fenglong (ST 40), Qiuxu (GB 40) and Taichong (LR 3), once every day, 5 times a week, the 4 weeks of treatment made one session. There was an interval of 1 week between the two sessions in the two groups. Totally, 2 sessions of treatment were required. Before and after treatment, the sensory and motor scores, modified barthel index (MBI) and blood rheological indices were observed, and the clinical efficacy was evaluated in the patients of the two groups.

RESULTSAfter 8 weeks of treatment, the total effective rate was 90.0% (27/30) in the catgut implantation group, which was better than 65.5% (19/29) in the acupuncture group (P < 0.05). FugI-Meyer motor function, sensory function scores and MBI were all improved as compared with those before treat ment in the two groups (all P < 0.05), and the results in the catgut implantation group was superior to the acu puncture group (all P < 0.05). The levels of whole blood viscosity, erythrocyte hematocrit, platelet aggregation and fibrinogen were improved as compared with those before treatment (all P < 0.05), and the results in the catgut implantation group was better than those in the acupuncture group (all P < 0.05).

CONCLUSIONThe catgut implantation at scalp reflecting foci achieves a satisfactory clinical efficacy on post-stroke sensory disturbance and improves the blood rheological indices.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Aged, 80 and over ; Catgut ; utilization ; Female ; Humans ; Male ; Middle Aged ; Prostheses and Implants ; Sensation ; Stroke ; physiopathology ; therapy ; Treatment Outcome