Objective To discuss the clinical effect of entecavir in treatment of hepatitis B-related nephritis. Methods 28 patients with hepatitis B-related nephritis diagnosed in our hospital through needling biopsy of kidney from 2009 to 2012 were selected in this study. All patients were given oral entecavir, besides conprehensive treatments,including potassium aspartate and diammonium glycyrrhizinate. The treatment course was three months. We observed and analyzed patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses.Results After one treatment course, the overall effective rate was 82.14%. Two courses later, the overall effective rate was 96.43%. Patients' serum glutamic pyruvic transaminase, serum albumin and urine protein within 24 hours after two treatment courses had significant differences with those before treatment's,the difference had statistical significance ( <0.05),but serum creatinine had no significant change after treatment. Conclusion Entecavir has significant curative effect on hepatitis B-related nephritis.

Fracture Fixation ; methods ; trends ; Fractures, Bone ; surgery ; Humans ; Pelvic Bones ; injuries ; surgery

China ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health ; legislation & jurisprudence ; Occupational Health Services ; organization & administration ; standards

Mycoplasma pneumoniae(MP) is a common pathogen of community-acquired pneumonia in children.In recent years,with increase in the incidence of MP infection,the severe cases caused by the later pathogen are also incresing.At present the pathogenesis of severe Mycoplasma pneumoniae pneumonia(SMPP) is still not very explicit,and increased macrolide resistance of MP made a great impact on the treatment.This article reviewed the recent progress in the study of the pathogenesis,clinical manifestations,diagnosis and treatment of SMPP.

Diabetic retinopathy (DR) is the leading causes of blindness in working-aged people,of which diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the two main causes of vision-threatening.Through the regular screening of patients with diabetes,the risk factors of DR can be identified and proper interventions can prevent the incidence of DR.Timely retinal laser photocoagulation and application of the renin-angiotensin system inhibitors (candesartan or fibrates),lipid-lowering drug fenofibrate can inhibit DR progress.Macula local and (or) grid pattern photocoagulation or in combination with bevacizumab intravitreal injection can effectively relief DME.In regard to late PDR,vitrectomy couldrestore or retain useful vision, importantly, minimally invasive 23G vitrectomy and preoperative bevacizumab intravitreal injection greatly improved the surgical outcomes.However DR pathogenesis is not entirely clear.Also there is a lack of effective and feasible DR screening strategy in China.Furthermore existing evidence-based data of medical and surgical treatment of DR is insufficient.Therefore,the DR prevention and treatment is still a long way to go in China.

The clinical application of POCT technology is growing wider,the most significant advantage of this technology is to get the test results quickly,Therefore clinicians could make clinical decisions in time and choose appropriate approaches or interventions.However,it should be taken seriously that while POCT helps patients to get medical care successfully,the potential harm to the patients cannot be ignored.Hence it is essential that normative documents should be imposed as soon as possible.The technology of POCT can benefit the entire society only if the proper administration to approve the use of POCT technology is taken control of; the comprehensive and normative quality management is implemented,and the appropriate training to the related clinicians and nurses is enforced.

Objective To compare the clinical effect of three Endobutton plates and clavicular hook plate in treatment of acromioclavicular joint dislocation.Methods Forty-two patients with acromioclavicular joint dislocation were randomly divided into EB group (20 patients) who were treated with three Endobutton plates and CH group (22 patients) who were treated with clavicular hook plate from January 2008 to January 2011.Perioperative index (operation time,blood loss and VAS scores on the third day postoperatively),Karlsson shoulder joint function scores and postoperative complication were compared.Results The operation time and blood loss in EB group were significantly higher than those in CH group [(113.6 ± 25.3)minvs.(62.3±17.8)min,(152.7±15.2) mlvs.(93.1±18.9)ml,P＜0.O5].However,therehadno significant difference for VAS scores on the third day postoperatively between two groups (P ＞ 0.05).EB group was superior to CH group for shoulder joint function scores on the twelfth month postoperatively,but there had no significant difference [95.0％ (19/20) vs.81.8％ (18/22),P ＞ 0.05].The incidence rate of shoulder joint pain and stiffness in EB group were significant lower than those in CH group[20.0 ％ (4/20) vs.50.0％(11/22),20.0％(4/20) vs.54.5％(12/22),P ＜ 0.05].The incidence rate of incision infection in two groups had no significant difference (P ＞ 0.05).Conclusions Compared with clavicular hook plate,three Endobutton plates fixation is complex and consequently with more blood loss.However,three Endobutton plates fixation have advantage in clinical effect and complication.

Objective To study the effectiveness of alkaline electrolyzed water (AEW)in the cleaning of medical instruments and its corrosive effect on metal. Methods Medical instruments of solid smooth,solid with gear or tube were cleaned with AEW adding ultrasonic washing,cleaning efficacy were compared with conventional method, AEW without pulsing ultrasonic washing and control group,corrosive effect of AEW on metal immersed in AEW was tested. Results Cleaning efficacy of solid smooth,solid with gear or tube instruments were significantly differ-ent among four groups(F= 10.868,14.268,6.146,respectively,all P<0.05). For solid smooth instruments, cleaning with AEW adding ultrasonic and cleaning without ultrasonic had a better effect than conventional cleaning (both P<0.005);For solid with gear instruments,AEW adding ultrasonic cleaning obviously had a better effect than conventional cleaning and AEW without ultrasonic cleaning(both P<0.001 );For tube instruments,cleaning efficacy of three cleaning methods were not significantly different (all P>0.05). AEW had no corrosive effect on stainless steel and copper. Conclusion The cleaning efficacy of AEW on solid smooth,solid with gear instruments is su-perior to conventional cleaning method,and can achieve better effectiveness if ultrasonic cleaning is added.

Aim This study aimed to observe effects of tyroserleutide(tyrosyl-seryl-leucine,YSL) on the survival time of mice transplanted with the ascitic fluid-type hepatocarcinoma H_(22),as well as the T lymphocyte transformation and killing activity of NK cell impacted by YSL on mice bearing H_(22) tumor.Methods The model of ascetic fluid-type hepatocarcinoma H_(22) was established and the survival time of mice bearing H_(22) tumor treated by YSL was observed.MTT was used to observe the effect of lymphocyte transformation and killing activity of NK cells activated by YSL in vitro.Results YSL could significantly prolong the survival time of mice bearing ascetic fluid-type hepatocarcinoma H_(22).At doses of 5 and 50 ?g?kg~(1),YSL could advance the T lymphocyte transformation.At doses of 0.5,5 and 50 ?g?kg~(-1),YSL could enhance the killing activity of NK cells on mice bearing H_(22) tumor.Conclusion YSL can significantly prolong the survival time of mice bearing fluid-type hepatocarcinoma H_(22) and promote the effect of T lymphocyte transformation and NK cell killing activity.

The zymograms of lactate dehydrogenase (LDH) and esterase (EST) isoenzymes in different physiologic state from two species of Anopheles mosquitoes were studied with polyacrylamide gel electro -phoresis. Some zymogram variation of LDH from single female mosquito was found after engorged blood meals for 48 h, that consisted of two main bands whose relative mobility (Rm) was different. The isozymograms of EST showed some similar characteristics of sibling which divided into three groups ESTⅠ, ESTⅡand ESTⅢ, respectively. The two species of mosquitoes could be differentiated from each other by the particular band in EST Ⅱ group of An. anthropophagus.