Objective To estimate the clinical application of plasmic endotoxin detection in the treatment of sepsis.Methods 36 septic patients admitted in our intensive care unit were observed prospectively.The endotoxin, white blood cell, C-reaction protein and procalcitonin were detected.After that, the relationships between endotoxin and white blood cell, C-reaction protein, procalcitonin, gastrointestinal dysfunction respectively were analyzed.Re-sults The mortality and the endotoxin level were both higher in patients with septic shock than those in the septic pa-tients without septic shock ( P<0.05) .There were no significantly statistical differences between endotoxin concen-tration and gastrointestinal dysfunction, white blood cells, or C-reaction protein respectively (P>0.05).However, there was statistically difference between endotoxin concentration in plasma and procalcitonin ( r =0.462, P =0.039) .Conclusion The risk of poor prognosis is larger while shock occurs in the septic patients.Endotoxin is re-lated to shock and serum procalcitonin.