Objective To dynamically measure cardiac output in shock neonates and to explore its clinical values.Methods The cardiac output and stroke volume of left ventricle in 30 shock neonates and 30 normal neonates were measured by noninvasive ultrasonic cardiac output monitor (USCOM) and the measurement was repeated in shock neonates after volume expansion and dopamine(2-4μg/(kg·min))treatment.Results The cardiac output and stroke volume of left ventricle in shock neonates ((0.36 ± 0.24) L/min,(3.5 ± 1.5) cm~3) were significantly lower than those in normal neonates ((0.49 ± 0.15) L/min,(2.7 ± 1.6) cm~3)) and however were improved significantly after volume expansion and dopamine treatment ((0.52 ± 0.28) L/min,(3.8 ± 1.8) cm~3).The urine volume was also increased significantly after treatment (P < 0.05).Conclusions Dynamic measurement of the cardiac output in early shock neonates might offer guidance on clinical fluid resuscitation.

The indoor air formaldehyde pollution has some adverse effects on human health. A number of researches have been reported on appropriate fitment and other measures to reduce the harm of indoor air formaldehyde pollution. The research progress of pollution control measures and the adverse effect of formaldehyde on human health were reviewed in the present paper.

Objective To know the drinking water quality,latrine improvement and fecal,domestic garbage,sewage treatment in the rural areas in Guangxi Province.Methods The survey was carried out according to "National Scheme on Current Situation of Rural Drinking Water and Sanitation" from July to December,2006.The water samples were collected in rain season(August 2006).2 414 houses were investigated in 241 administrative villages of 23 counties.Results In the rural population,31.66% was served by central supply,68.34% was served by non-central supply in Guangxi Province.22.22% of the people used surface water and 77.78% used ground water.The eligible rate of water quality was 21.58%.As for surface water,the eligible rate was 32.76%,as for ground water,it was 18.03%.As for central water supply,the eligible rate was 24.06%,as for non-central water supply,it was 18.52%.The eligible rate of total count of bacteria and total coliform was only 62.24% and 29.88% respectively.The sanitary latrine rate was only 43.79%.The treatment rate of domestic garbage was 45.57%,industrial garbage was 80.17%.No domestic sewage was treated,the treatment rate of production wastewater was very low(only 1.59%).Conclusion The drinking water quality and sanitation in the rural areas in Guangxi Province should be improved as early as possible.

Objective To understand and master the dynamic changes and contributing factors to Guangxi rural drinking water quality. Methods No less than 25% of counties in Guangxi Zhuang Autonomous Region were randomly selected according to the proportional stratified sampling method to build the monitoring network for the dynamic monitoring of rural drinking water quality. The sampling time was arranged in the rainy (July or August) and dry season (March or November) in 2007 and 2008, respectively. The test methods were those documented in the standard (GB 5750-2006). Results The coverage rate of rural centralized water supply was 35.72% in 2008, higher than that in 2007 (31.80%) by 3.92%; the eligible rate of water quality in 2007 and 2008 were 20.57% and 24.59% respectively. The eligible rate of water quality in dry season was higher compared with that in the rainy season. Among all the monitoring indexes, the microbiological index ranked the lowest in terms of eligible rate, ranging from 34.76% to 80.68% for central water systems, and from 21.43% to 66.57% for non-central water supply. Conclusion Microbiological pollution is the main influencing factor for drinking water quality in rural areas in Guangxi Zhuang Autonomous Region.

Objective To know the environmental lead pollution status of rural areas around the mining area in Guangxi,2008.Methods From August to December,2008,the survey was carried out in 28 villages of 4 counties,which were located in basin of three rivers and their tributaries.Six lead-zinc-tin mines were situated in the investigated area.The local samples were collected,including 101 rice samples,30 paddy samples,59 vegetable samples and 45 samples of meat,viscera of poultry,5 fish samples,and 27 surface water samples,12 ground water samples,13 drinking water samples,29 cropland soil samples.The lead content of them were determined,the dietary survey on lead intake was performed among the residents living near the mining area also.Results 53.68%(102/190) of the crop samples revealed higher lead contents,which were over the standard limit,especially for rice(47.52%) and leafy vegetables(100%).The lead contents for five eggs samples,two peanuts samples and thirteen fresh corns were qualified.36%(102/190)of the samples of meat and viscera of poultry revealed higher lead contents,which were over the standard limit,especially for liver and chicken intestine.The lead intake only through rice and vegetables reached 4.55 mg in one week,which was over the tolerance dose by 0.52 times.Conclusion The lead intake of the residents living near the lead-zinc mining area are mainly from crop and vegetables and poultry.Environmental lead pollution is serious in the investigated area and must be controlled as possible as early.

Objective To know the current situation of drinking water quality and the influencing factors of provided for oneself water supply in rural schools in Guangxi.Methods According to the randomly proportionate stratification (economic,geography and topography etc.),43 and 50 counties were selected in 2007 and 2008 and the monitoring sites from 3 rural schools with provided for oneself water supply facility were taken out based on the proportion of water sources and technical patterns coverage in each county.The survey on water supply technical patterns,water sources and their coverage was conducted.One hundred and thirty,one hundred and fifty-three monitoring sites in rain season (July or August) and dry season (March or November) were monitored separately in 2007 and 2008.The monitoring results of drinking water were assessed according to Sanitary Standards for Drinking Water Quality (GB5749-2006).Results The groundwater was main drinking water source,which were 84.03% and 90.75% in 2007 and 2008.Most of water supply had not any water treatment,which was 75.86% in 2007 and 64.22% in 2008.The qualified rate in rain season (18.02%) was significant lower than dry season (31.80%) (P

Objective To investigate the quality of drinking water produced by safe drinking water projects in rural areas of Guangxi.Methods A survey of water quality was conducted from January to October 2008,in the drinking water projects funded by treasure bonds in 89 counties (cities and districts) of Guangxi.The water samples were collected from waterworks and tap water in dry season (March) and rainy season (July to August),respectively,and evaluated for aesthetic,microbiologic and chemical indexes.Results A total of 1 327 drinking water projects were surveyed.58.25% had a daily output under 100 tons,and only 2.71% had an output over 1 000 tons (enough for 10 000 persons).Only 12.28% adopted comprehensive water treatment process (i.e.coagulation,sedimentation,filtration and disinfection),whereas 62.85% did not provide any treatment.Up to 79.80% had no disinfection equipment and 90% failed to provide effective disinfection.25.21% and 21.48% of finished water,and 25.78% and 20.59% of tap water samples tested up to the standard respectively in the dry season and rainy season.Over 88% of water samples met the aesthetic,chemical and toxicological standards (100% up to standard for chronic,arsenic and fluoride),while 73.16%-80.78% met the standard for bacterial count,30.86%-36.17% for fecal coliforms and 41.86%-47.73% for thermotolerant coliforms.Conclusion The study results indicate that the inadequate supply of safe water,absence of water treatment facilities and poor drinking water quality have represented a potential health risk in Guangxi rural areas.

Xiaochaihu Decoction comes from Shang Han Lun, which is a main formula for Shaoyang diseases. According to the principle of prescriptions corresponding to syndromes, the clinical application of modified Xiaochaihu Decoction for the treatment of swelling, pain, nausea, vomiting, bloating, and constipation after artificial total knee arthroplasty can achieve good efficacy.

Objective To study the effect of GAH on lymphocytes proliferation and its mechanism. Methods MTT, fluorescence probe and immunofluorescent methods were used to investigate the effects of GAH on the lymphocytes proliferation, intracelluar Ca2+ concentration and expression of calcineurin(CaN). Results GHA induced lymphocyte proliferation, raised the intracelluar Ca2+ concentration and calcineurin expression. Conclusions GAH is a new kind of activator, which can induce lymphocyte proliferation through Ca2+ signal pathway.

Objective: To study the therapeutic effect of secondary lymphoid tissue chemokine (SLC) combined with CpG oligodeoxynucleotide (CpG-ODN) in treatment of implanted mouse melanoma and the possible mechanism. Methods: SLC-Fc fusion protein was prepared and its chemotaxis of lymphocytes was detected by chemotaxis assay. Implanted melanoma mouse models were established and randomly divided into 4 groups: control group, SLC-Fc group, CpG-ODN group, and SLC-Fc+CpG-ODN group. The growth of implanted tumors in each group was observed after treatment. Subtype and infiltration of lymphocytes in implanted tumor tissues were examined by flow cytometry. Results: SLC-Fc protein was successfully prepared, and it dose-dependently attracted lymphocytes (0.03, 0.3, and 3 μg/L). Intra-tumor injection SLC-Fc and CpG-ODN alone or in combination significantly inhibited growth of B16-implanted tumors. Tumor size in SLC-Fc+CpG-ODN group was significantly smaller than that in control group (P<0.01), and animals in SLC-Fc+CpG-ODN group survived longer. Tumor-infiltrated CD4~+ T, CD~8+ T, and dendritic cells (DCs) in SLC-Fc+CpG-ODN group were markedly increased as compared with those in control group (P<0.05), and tumor draining lymph nodes were dramatically enlarged. Conclusion: SLC combined with CpG-ODN can inhibit the growth of implanted melanoma by attracting CD4~+ T and CD8~+ T and promoting proliferation of DCs.