Objective:To further analyze the reasons for operating loss of the sample hospital so as to resolve the developing predicament of children's hospitals.Methods:The financial data of the sample hospital from 2013 to 2015 were selected to compare the workload,incone structure,average cost and project cost before and after the medical reform so as to analyze the reason for the operation loss of the sample hospital.Results:According to the analysis results,the operating loss of sample hospital could be attributed to the following reasons:the healthcare pricing was underpaid with the high service costs,the quantity of outpatient service declined with the change of income structure,the financial compensation by legal was not fully funded.Conclusion:From the perspective of external policy,government medical service pricing should reflect the particularity of pediatrics.Government should increase the public subsidy to children's hospital.From the perspective of hospitals,children's hospital should optimize the service process,develop the characteristics of specialized pediatrics and control the medical cost to improve health care quality while improving market competitiveness.

Objective To explore the clinical efficacy and complications of vitreoretinal diseases and cataract treated with combined surgical approach.Methods A retrospective analysis of 294 eyes received vitrectomy combined with cataract surgery was conducted.The clinical effect and complications of combined surgery in the treatment of various vitreoretinal diseases with cataract were analyzed.Results Of 294 eyes,visual acuity improved in 236eyes(80.3％);unchanged vision in 32 eyes; vision loss in 26 eyes.Phase Ⅰ of the implanted IOL for a total of 34eyes,visual acuity was improved (100.0％),there were 260 eyes not implanted IOL,corrected visual acuity improved in 202 eyes (78.0％),the vision improvement between the two groups had no statistically significant difference (x2 =0.301,P ＞ 0.05).Conclusion The combined treatment of vitreoretinal surgery is an effective way to cataract disease,the clinical effect is good,which is worthy of promotion.

To investigate the clinical effect of pantoprazole combined with traditional Chinese medicine for gastroesophageal reflux. A total of 50 cases of gastroesophageal reflux selected from January 2019 to December 2019 in Aviation General Hospital were randomly divided into the control group and the observation group. The control group was given pantoprazole, and the observation group was given traditional Chinese medicine combined with pantoprazole. Both groups were treated for 28 days. The recovery of clinical symptoms, status of esophageal mucosa by endoscopy and the incidence of adverse reactions were compared between the two groups. The clinical symptoms and status of esophageal mucosa in both group were obviously improved. Efficiency of the observation group was significantly higher than that of the control group( P<0.05). No serious adverse reactions happened during treatment. Pantoprazole combined with traditional Chinese medicine has definite clinical effects in the treatment of gastroesophageal reflux, which can improve the clinical symptoms and the recovery of esophageal mucosa of patients with high safety.

Aplastic anemia(AA)is a rare disease oringed from hematopoietic cell,characterized by failure of the bone marrow and pancytopenia in peripheral blood.The mechanism of AA is indistinct,it can be congenital,or acquired disposition.Acquired AA may be secondary to poisonous,radiation,virus infection and some medicine.All these factors can injure bone marrow directly,suppressing the proliferation and differentiation of bone marrow,on the other hand,the immune system play a pivotal role indirectly.This review focused on the pathologic classification,mechanism of drug-induced aplastic anemia.

Objective To study the effect of unsaturated fatty acid of Pinus koraiensis on lipid metabolism in rats. Method Unsaturated fatty acid was extracted and concentrated from Pinus koraiensis by supercritical fluid extraction and urea inclusion method. 40 rats were divided into 8 groups randomly. Except normal control group, the other groups were fed high fat diet. Normal control and obesity control groups were fed i.g. normal saline,Seed oil control group was fed i.g. pine nut oil and the other groups were fed i.g. 0.4, 0.8, 1.2, 1.6 and 2.0 g/kg bw unsaturated fatty acid. Body weights were weighed every week. After 4 w, the rats were killed, the serum total triglycerides(TG), total cholesterol(TC), high density lipoprotein cholesterol (HDL-C) and hepatic lipase(HL), lipoprotein lipase(LPL), liver lipofuscin (LP) were assayed. Results Compared with obesity control group, the body weight, body fat ratio, serum TG, LP and TC level were reduced remarkably. HL and total lipase (LA) level enhanced remarkably. Conclusion The unsaturated fatty acid of Pinus koraiensis could enhance the lipid metabolism in obese rats.

Objective To search for the mechanism of NO and TNOS/iNOS in cerebral vascular stenosis,the changes of these serum factors in different kinds of cerebral vascular stenosis were studied. Methods Biochemistry assays were adopted,to analyze serum NO and TNOS/iNOS in different vascular stenosis group. Results Serum NO contents of ' Mix' (P=0.000) or ' MCA' (P=0.001) significantly increased. INOS activity of ' In' (P=0.004) and ' MCA' (P=0.002) markedly increased. And TNOS activity of ' In' group significantly weakened (P=0.032),but the TNOS activity of ' Mix' (P=0.011) and ' MCA' (P=0.018) group markedly intensified. Conclusion NO and TNOS/ iNOS partly participate in the occurrence mechanism of cerebral vascular stenosis. And the study provided theory basis for studying multiple factors of cerebral vascular stenosis.

Leptomeningeal metastasis (LM),with a high omission rate in diagnosis in approximately 5 ％～8 ％ of all patients, is increasingly recognized as a lethality complication. The diagnosis of LM remains challenges,but commonly can be established by CSF cytology or by definitive neuroimaging. Although a combination of focal radiotherapy,intrathecal chemotherapy,and systemic chemotherapy may be necessary to achieve optimal treatment of patients, but prognosis is unacceptable and therapy remains palliative in most patients.

Objective To discuss the microsurgical treatment for tethered cord syndrome (TCS) caused by intraspinal lipomas. Methods Thirty-two patients with intraspinal lipoma TCS were treated microsurgically. On surgery the tethering lesions of lipoma were excised and anomalies restricting the spinal cord were removed. Results Following the operation, cerebrospinal fluid subcutaneous leakage had occurred in 3 patients, who were cured by expectant treatment. The patients were followed for 3~12 months (mean, 6 months). Five patients were cured, 21 got improved, and 6 had no change. Conclusions Application of microsurgical technique for intraspinal lipoma TCS has advantages of fewer complications and better improvement of nerve functions.