Objective To observe the effect on depressurization and quality of life through Jiangya capsule combined with nimodipine treatment.Methods Randomized,blind and control trial was applied.One hundred and twenty elderly isolated systolic hypertension (EISH) patients were randomly assigned to Jiangya capsule combined with nimodipine group (treatment group) 60 cases (6 cases were lost and 54 cases were in analysis) or nimodipine group (control group) 60 cases (13 cases were lost and 47 cases were in analysis).Treatment group was administrated with Jiangya capsule and nimodipine,and control group was administrated with nimodipine and Jiangya capsule placebo.The course of treatment was 4 weeks.The blood pressure and quality of life of the two groups were observed before and after treatment.Results SBP was obviously decreased in treatment group compared with control group (P0.05).Symptom scores of yin deficiency and yang hyperactivity syndrome in treatment group was improved and superior to the other syndromes in treatment group and control group (P