Objective To explore the expression of costimulatory molecules of CD28 and CD152 for patients with chronic hepatitis B(CHB).Methods Flow cytometric analysis was applied to detect the expression level of CD28/CD152 on CD4+ or CD8+ T lymphocyte subpopulations.Results Compared with control group,the percentage of CD4+CD28+ and CD8+CD28+ increased significantly(P

Objective To investigate the prevalence of overweight and obesity in Chinese children and adoles cents,in order to provide the basis for developing obesity precautionary and control measures.Methods The data was extracted from the work in revision of National Student Physical Fitness Standard,including 120 275 children and adolescents of 7-18 years old.The Chinese body mass index criteria was used for screening overweight and obesity.Results the overall prevalence of obese was 7.1 ％ (boys:9.1％,girls:5.2％),of which 12.2％ (boys:14.6％,girls:9.8％) were overweight.The prevalence of obesity was decreased gradually with increasing age,but the boys' prevalence at the age of 9 and the girls' prevalence at the age of 16-17 was rebounded slightly.The obesity of children and adolescents from rural areas was in a significant growth stage,the prevalence of obesity was 4.6％ and overweight was 9.6％.There were differences between Han students and minority students,the Han'prevalence of obesity and overweight were 2.3％ and 3.2％higher than minority.The highest prevalence of overweight and obesity in Provincial Center City.The prevalence characteristic of obesity was uneven among different geographic areas,and was the maximum in North China and the minimum in Southern China.Conclusions The prevalence of obesity and overweight is higher among the males,primary students,rural areas,Han students,Provincial Center Cities,North and northeast areas.A targeted strategies and measures for obesity-prevention should be conducted.

Objective To investigate the impact of prior cerebral infarction (PCI) on in-hospital mortality in patients with Acute Myocardial Infarction (AMI).MethodsA retrospective analysis of documents of a total of 3572 consecutive patients with AMI admitted to Xuanwu Hospital of Capital Medical University from 2002 Jan.1 to 2009 Dec.31 were performed.Results There were 564 patients ( 15.8% )with PCI.Compared with the group of without PC1,the group with PCI were substantially older[(69.4 ±9.9) vs (64.2 ± 12.9)years,P =0.000],and had a higher prevalence of hypertensive disease,diabetes mellitus,prior myocardial infarction (MI) and non-ST-segment elevation myocardial infarction(NSTEMI)( respectively,71.0% vs 57.3%; 41.0% vs 25.7%,12.9% vs 9.5%; 14.9% vs 10.7%,P ＜ 0.01 ),and a higher in-hospital mortality ( 16.5% vs 10.0%,P= 0.000).Univariate analysis demonstrated that in-hospital mortality associated with age,gender,extensive anterior MI,anterior MI,diabetes mellitus,prior cerebral infarction,prior myocardial infarction,coronary angiography and percutaneous coronary intervention.Logistic regression analysis found that risk factors were age,extensive anterior MI,anterior MI,diabetes mellitus and prior cerebral infarction,and protective factors were coronary angiography and percutanous coronary intervention.PCI was independently associated with in-hospital mortality,OR 1.368,95% CI 1.047-1.787,P = 0.022.Conclusion In patients with acute myocardial infarction,the presence of PCI increases the risk of worse in-hospital outcome.

Objective: To investigate the correlation between fat mass percentage(FM%), fat mass index(FMI), fat free mass index(FFMI), body mass index (BMI) and physical fitness, and to explore the potential value of body composition index in predicting physical exercise level of children and adolescents. Methods: Data came from 2013 revision of National Students Physical Health Standard of Ministry of Education in Beijing. Body composition of 4 069 children and adolescents aged 6-20 years in Beijing was measured by the BIA(inbody 230). FM, FMI, FFMI and BMI were divided into four groups by quartile method. The differences and trends of the four groups were analyzed by graphpad prism 8.0 software. Results: FM% (20.03±10.39) and FMIS [(4.35± 2.84 )kg/m 2] of oys were significantly lower than those of girls, while FFMI [(14.21±4.95)kg/m 2] and BMI [(20.31±4.27) kg/m 2 ] of boys were significantly higher than those of girls( t =-13.36, -7.66, 11.49, 8.16, P <0.01). In boys, with the increase of FM% and FMI, the performance of 50 m, 1 000 m, standing long jump and pull up showed a downward trend; with the increase of FFMI, the performance of 50 m, standing long jump and pull up had an obvious upward trend. In girls, with the increase of FM% and FMI, the 50 m running time was gradually shortened, and the 800 m running time was gradually increasing; High FFMI was associated with higher performance in 50 m running, while no association was observed between FFMI and 800 m running.Four body composition indicators showed no effects on performance of sitting forward flexion and 1 minute sit up. Conclusion FM%, FMI, FFMI and BMI have a good predictive effect on physical fitness of children and adolescents. Adolescents with higher FFMI, lower FM% and FMI have better muscle burst strength, muscle endurance, flexibility, aerobic ability and anaerobic ability, especially in boys.