Objective To explore the effects and safety of escitalopram on suicide-related symptoms for depression patients controlled with amitriptyline.Methods Depression patients with suicide-related symptoms were randomly grouped.The study group(n=35) were treated with escitalopram 10 mg/d to 20 mg/d and the control group(n=33) were done with amitriptyline 75 mg to 250 mg daily.Both groups with psychotherapy were carried out for 8 weeks' observation.The Hamilton Depression Rating Scale (HAMD-17) and Clinical Global Impression-severity of illness (CGI-SI) were tested and suicide-related examined before and after 1,2,4,6 and 8 weeks'treatment.The Treatment Emergent Symptom Scale (TESS) was checked at 4th week to evaluate safety.Results In the study group,the incidence of wishing to die (97.1％),suicidal attempts (91.4％),suicidal ideations (88.6％),suicidal plans (80.0％),hopelessness (71.4％) and suicidal behavior (54.3％) was similar to the control group(97.0％,97.0％,90.9％,87.9％,72.7％ and 54.5％,respectively,x2 =0.00-0.94,P＞0.05).The incidence of suicide-related symptoms showed significantly lower after treatment than before (P＜0.01).At 1st week treatment,the incidences of hopelessness (37.1％),suicidal plans (45.7％) and suicidal ideations (48.6％)showed significantly lower in the study group than those in the control group(63.6％,72.7％ and 75.8％,respectively,x2 =4.77,5.12,5.32,P＜ 0.05).The study group showed significantly lower side-effects (11.4％) at 4th weeks' treatment than the control group(62.9％,x2 =21.95,P＜0.01).Conclusion The effects of escitalopram on suicide-related symptoms for depression patients is similar to amitriptyline but with faster effect and higher safety.

Objective To evaluate the role of antidepressants in the treatment of functional dyspepsia (FD). Methods 90 cases of FD with anxious depressive manifestations were randomizely allocated into antidyspepsia group, antidepressant group and antidyspepsia and antidepressants combination group. All patients were treated for 8 weeks. Results FD scores(upper abdominal distention, satiety, abdominal pain, belching) with Zung depression scale and HAMD scale decreased after treatment in all three groups. Symptoms in combination group improved with a total efficacy rate of 86.7%, and HAMD efficacy rate 86.7%. Both were much higher than those in antidyspepsia group(36.7% and 10.0%, respectively, P

Objective To compare the executive functions and releases function of hypothalamus-pituitary-adrenal (HPA) axis in patients with single and bipolar depression disorder. Methods 32 single-phase depression (the single group) and 31 bipolar depression patients (the bipolar group) were enrolled in this study. The trail making test A and B and Stroop test (Stroop-C and Stroop-CW) were tested at 0,4 week and 8 week later. In addition,levels of 24-h urine 17-OH cortisol,24-h urine free corticosterone and plasma cortisol were also detrmined. The related results were compared among the two groups and 28 healthycontrol group. Results The TMT-A,TMT-B,Stroop-C and Stroop-CW of the baseline and at 4 week were significantly longer in the depression group than those in the control group(P<0.01,respectively), and the plasma cortisol was also higher in the depression group than that in the control (P<0.01). On baseline, the single group showed significantly longer TMT-B and Stroop-C than those in the bipolar group (P < 0.01, respectively). At 0 week, lower plasma cortisol concentrations did not appear at 12.00 AM, and the midnight deep valley secretion disappeared. However, the midnight deep valley secretion recoveried at 4 week. Conclussion The differences on executive dysfunction and excessive release of HPA-axis function between the single and the bipolar depression should be followed with interest.

ObjectiveTo discuss the mental state and its influencing factors of perioperative patients with mania.Methods 40 perioperative mania patients were investigated with Bech-Rafaelsdn Mania Rating Scale (BRMS) and Life Event Scale(LES) ,assisted with self-designed influential factors to survey the correlation factors.ResultsThe perioperative patients were interestd in therapeutic correlation question preoperative and worry about their recovery after operation.The worry showed that operations was mental work load and psycho-burden to the patients.Perioperative patients' mental activities were main of perceptual insecurity.The psycho-feature must influence the compliance of mania patients' therapy and nursing.What follows next is the quality of therapy and nursing.ConclusionThe main problem to be solved is intervention the tension, anxiety, scare psychology of the patients in perioperative.At the same time it must be strengthened to talk to the family member of the patients knowledge about the disease and its recovery.

Objective To discuss the intervention effect of cognition therapy for perioperative patients of digestive tract with depression and/or anxiety symptoms.Methods 135 patients with digestive tract operation were randomly divided into intervention group and non-intervention group.The patients in intervention group accepted cognition therapy.The Mores of SDS and SAS,the curative effect and hospitalized time were compared among the two groups and the norlns of our country at last.Results (1)The scores of SDS and SAS in the two group patients in pre-operation were no difference(P＞0.05),but all were significantly higher than those of the norms of our country(P＜0.01).It indicated that patients have evident depression and/or anxiety symptoms pre-operation. (2)Compared with pre-operation,the scores of SDS and SAS in the intervention group patients showed significantly lower after operation(P＜0.01),which returned to the norms of our country(P＞0.05),and showed lower than those of the non-intervention group predominantly (P＜0.01).This indicated that cognition therapy can relieve the depression and/or anxiety symptoms of the perioperative patients.(3)Though the therapeutic effect of the two group are similar(P＞0.05),but the hospitalized fime decurated in the intervention group predominantly(P＜0.01).Conclusion The periopexative patients of digestive tract had obvious depression and/or anxiety symptoms.Cognition therapy could relieve the depression and/or anxiety sympmms of the perioperative patients,this was helpful for patients to recover early.

Objective To analyze the differences in social psychological characteristics of patients with different subtypes of functional dyspepsia (FD).Methods From August 2011 to July 2015,210 FD patients met Rome Ⅲ criteria were enrolled and divided into pure postprandial distress syndrome (PDS)group (69 cases),pure epigastric pain syndrome (EPS) group (74 cases) and PDS overlap EPS (PDS+ EPS) group (67 cases).Hamilton depression scale (HAMD),Hamilton anxiety scale (HAMA),life event scale (LES) and Eysenck's personality questionnaire (EPQ) were used for evaluation.Chi-square test and least-significant difference were performed for statistical analysis.Results Incidence rates of depression and anxiety of PDS+EPS group were both 100.0％ (67/67),which were higher than those of pure PDS group (84.1％,58/69 and 91.3％,63/69),and the differences were statistically significant (x2 =11.62 and 16.34,both P＜0.01);which were also higher than those of pure EPS group (78.4％,58/74 and 90.5％,67/74),and the differences were statistically significant (x2 =6.10 and 6.67,both P＜0.05).Somatic anxiety score and mental anxiety score of PDS+ EPS group were 16.34±3.70 and 14.18±2.99,respectively;which were higher than those of pure PDS group (11.26±3.42 and 10.70±2.94) and pure EPS group (12.30 ± 4.29 and 10.36 ± 2.63),and the differences were statistically significant (t=8.33,5.97,6.85 and 8.06;all P＜0.01).The top two life events in three groups were sleeping habits alteration (67.6％,142/210) and severe disease or trauma (26.7％,56/210).The incidence rate of sleeping habits alteration in pure PDS group was 53.6 ％ (37/69),which was lower than that in pure EPSgroup (77.0％,57/74) and PDS+EPS group (71.6％,48/67),and the differences were statistically significant (x2 =8.68 and 4.71,both P＜0.05).Most of P scale scores of pure PDS group,pure EPS group and PDS+EPS group were normal,most of E and L scale scores were low;most of N scale scores of pure PDS group were low,and these of pure EPS group and PDS+EPS group were normal.Conclusions The incidence of depression and anxiety of PDS+EPS group is the highest.Somatic anxiety is more obvious than mental anxiety in PDS+EPS group and pure EPS group,most with sleep events.Slow emotional response is common in pure PDS group.

Objective:To investigate the evaluation of disease perception, treatment compliance and community follow-up services of community schizophrenia patients, family members and personnel in Shantou City, and to provide a reference basis for improving the quality of management treatment.Methods:With the method of stratified sampling qualitative research, a community sample of 17 198 patients with schizophrenia in seven districts or county in Shantou City were sampled from February to August 2019, with 2 towns being drawn from each district or county, and 10 patients, 10 family members and 3 personnel were selected in each town. The evaluation of disease perception, treatment compliance and community follow-up services were investigated and analyzed. Respondents were eventually included in 137 patients, 138 family members and 41 personnel.The interviewees were conducted with semi-structured interviews, the data were collected according to traditional methods, and the descriptive statistical analysis was carried out with SPSS 12.0.Results:(1)34.3% of patients and 32.6% of the family members were not fully aware of the disease.22.6% of the patients and 23.2% of the family members had a sense of ill shame. (2)26.3% of patients did not comply with treatment, 29.9% of patients had not insight, 53.3% of patients and 24.6% of family members on the side effects of drugs and addiction understood improperly, and, 35.0% of patients and 13.0% of the family had a misunderstanding of illness and using drugs. (3)29.2% of patients and 31.2% of their families were tired of taking long-term medication, 24.8% of patients and 21.0% of their families felt socially isolated, and, 17.5% felt unsupported and 18.8% of their families admitted that they did not care enough about patients. (4)31.4% of patients did not actively receive follow-up services, 37.2% of patients and 20.3% of family members did not cooperate with follow-up doctors, and, 21.2% of patients and 10.1% of family members were not satisfied with follow-up services. (5)The personnel of psychiatric care could basically grasp the conditions of patients in the jurisdiction and carried out follow-up services on a regular basis (90.2%), master emergency disposal methods (92.7%), and have carried out training (97.6%). However, the psychiatric practice of the personnel were lower than (58.5%) and most lying part-time (78.0%), the average length of service was 5.7±1.4 years. The personnel satisfaction with the community follow-up service was higher (95.1%), but most of them thought that the psychiatric care was more difficult (36.6%), and were dissatisfied with the multi-functional staff to undertake a number of public services (31.7%).Conclusion:The management treatment project of mental disorders services in Shantou City show initial results.The patients were satisfied with the community follow-up service, but the patients and their families still have low level of cognition, poor compliance, obvious negative emotions, and have concerns about drug treatment.It is necessary to strengthen the professionalization of personnel, to carry out early mental health education and rational emotional behavior training for patients and their families.