Objective:To discuss the application of ethical review of biomedical research system in the hospital ethical review of biomedical research.Methods: To design based on the ICH GCP specification, WHO/TDR biomedical research ethics committee guidelines Systematic, WHO SIDCER authentication on the ethics committee specification development.Results: The application of this system can realize the ethical review application, acceptance, examination and decision, convey the follow-up review procedures for electronic program.Conclusion: The ethical review of biomedical research ethics review system to make process more reasonable, operation more convenient, greatly improves the work efficiency of the hospital ethics review, document management, facilitate and regulate the ethical review, enhance the quality of management ethics review, plays an important role inbiomedical research ethics review.