Objective To discuss clinical and cytological features of cerebrospinal fluid (CSF) in meningeal careinomatosis (MC). Methods The data of clinic, imaging and CSF of 59 inpatients with MC were analyzed retrospectively. Results There were 91.5% (54 cases) of middle and elder aged in the group. Most of patients were at acute or subacute onset . Condition developed fast. 55 cases (93.2%) didn't feel fever primarily. Intracranial hypertension of headache (57 cases ),vomitted(45 cases ) and disc edema(21 cases ) ect. were predominant features. In 32 cases (54.2%), cranial nerves were involved. Optic never and abducent never damage appeared the most frequently. Oculomotor never, facial nerve and vestibulocochlear nerve were in the next. All of 59 cases had meningeal irritation sign, among them 31 cases (52.5%) with obvious sign. Tumor cells in cytological examination of CSF were found in all of 59 cases. Conclusions The clinical manifestations of MC has some certain features. Diagnosis of MC still relay on finding tumor cells in cytological examination of CSF.

Objective To study the clinical manifestation and MRI feature on toxic encephalopathy after inhaling and injecting heroin. Methods 4 patients with toxic encephalopathy induced by inhaling, injecting heroin were observed with clinical and MRI. Results The 4 patients were male, they all had definite addiction histories (the time of addiction for 4 months to 7 years), there were special language and retropulsive dystonia besides there were common characteristics of toxic encephalopathy: reaction retardation, disturbance of intelligence, MRI showed the change of generalized demyelination in bilateral symmetrical cerebral hemisphere, posterior limbs of internal capsule, corpus callosum, medial lemniscus, cerebellum hemisphere dentate nucleus. The clinical symptom of 1 patient treated by adrenocortical steroid disappeared nearly 11 months after the onset of disease, 2 patients’ condition was remitted 3 months after treatment, 1 patient with 7 years inhaling history died the 55th day after the deterioration of disease. Conclusion Clinical manifestation and MRI on toxic encephalopathy after inhaling and injecting heroin were known, so we could diagnose the patients of the disease in time.