The etiology of uveitis is very complicated and the pathogenesis is not yet clear.In recent years,more and more evidences imply that the chemokines interleukin-8 (IL-8) is involved in the development of uveitis.Studies of IL-8 and its network features contribute to the understanding of uveitis pathogenesis and provide an important foundation for seeking new indication of activity of uveitis and new treatment target.This paper summarizes the progression in the study on IL-8 in uveitis,including the physiology functions of IL-8,mechanisms for ocular inflammatory,and the role and performance of IL-8 in uveitis.

In this article,the author systematically summarized professor SUN Gui-zhi' academic thoughts about pathogeny and treatment of tumour.Professor SUN Gui-zhi thinks that the Phlegm is one of the most important pathogenic evils that induce tumour.As to cold and heat syndrome of tumour,she thinks that heat syndrome is more important.While to defi ciency and excess syndrome,she thinks excess syndrome primary in the early time,deficiency-excess in complexity in intermediate stage,and defi ciency syndrome primary in later period of tumour.In treatment of tumour,professor SUN Gui-zhi pays more attention to dispelling pathogenic evils of phlegm and heat,at the same time protecting stomach qi,and adjusting the helm opening and closing of qi movement.She is good at making complex and large prescription.

Objective To investigate the effects of inhalation of different concentrations of nitrous oxide on intracuff pressure (ICP) of the laryngeal mask airway (LMA) in patients during general anesthesia. Methods Forty-right ASA Ⅰ or Ⅱ patients aged 25-64 yr undergoing elective operations under general anesthesia were randomly divided into 4 groups (n=12 each): group C (100 %O2, group N2 (65 % O2 + 35%N2O), group N2 (50%O2 + 50 % N2O), and group N3 (35%O2 + 65%N2O). A suitable model of the LMA was selected according to height and weight. Anesthesia was induced with Ⅳ propofol 1.5-2.0 mg/kg, fentanyl 2-3 μg/kg, lidocaine 1-2 mg/kg and vecuronium 0.08-0.1 mg/kg and maintained with intravenous infusion of propofol and intermittent boluses of fentanyl and vecuronium. After the successful placement of LMA, the air was injected into the cuff to make intracuff pressure (ICP) reach 40 cm H2O (baseline). The ICP were recorded at 15, 30, 45, 60, 75 and 90 min (T1-6) following inhalation of N2O. Results The ICP grandually increased with the increase in the concentration of N2O (P<0.05). The ICP decreased at T2-6 in group C, but increased at T2-6 in group N1 and at T1-6 in group N2,3 as compared with baseline(P<0.05). There was a positive correlation between the ICP and inhalation time in group N1-3(r1-3=0.968,0.987,0.973 respectively, P<0.05). Conclusion The inhalation of N2O can increase the ICP in concentration- and time-dependent manners,

Most colorectal cancers develop from adenomas. Environmental factors play an important role in the development and progression of adenoma. Recently,epidemiologic investigations on lifestyle change including diet and exercise and drug intervention studies have proved the relationship between environmental factors and colorectal cancer. Screening,polypectomy and surveillance via colonoscopy are the main measures of colorectal cancer prevention. However, the efficacy is unsatisfactory. Therefore,attention should be paid to studies on colorectal cancer prophylaxis via intervention on environmental factors. Emphasis should be put on various aspects of environmental intervention in clinical practice,and prophylaxis strategies should be generated individually in accordance with the local condition and situation.

BACKGROUND:In recent years, cel transplantation therapy is widely used in the treatment of Parkinson’s disease with satisfactory outcomes. OBJECTIVE:To investigate the proliferation and differentiation of transplanted neural stem cel s in Parkinson’s disease rats, thereby providing a new theoretical basis for the treatment of Parkinson’s disease. METHODS:Neural stem cel s from the brain tissues of rats were isolated and cultured in vitro using col agenase digestion method. Unilateral rat model of Parkinson’s disease was made by 6-hydroxydopamine method, and the successful rat models were divided into model group and cel transplantation group, with seven rats in each group. The rats in the model group were given 4 mL normal saline at the damaged striatum, and those in the cel transplantation group were injected 5μL green fluorescent protein-labeled neural stem cel s (1×109/L) into the damaged striatum. RESULTS AND CONCLUSION:After cel transplantation, the positive area of tyrosine hydroxylase was significantly lower in the cel transplantation group than the model group. Compared with the model group, the expression level of Ptx3 mRNA was significantly higher in the cel transplantation group at 7, 14, 28 days after cel transplantation and the expression of SHH mRNA was significantly higher in the cel transplantation group at 14 and 28 days after cel transplantation. However, there was no difference in the expression of Nurrl mRNA between the two groups. These findings indicate that neural stem cel s injected into the damaged striatum of rats can differentiate into dopaminergic neurons, which bring a breakthrough in the treatment of Parkinson’s disease.

Objective To investigate the role of interleukin-22 (IL-22) in the pathogenesis of pityriasis rosea (PR).Methods Peripheral venous blood samples were obtained from 48 patients with PR in acute stage and recovery stage and from 20 healthy human controls.Real-time fluorescence-based quantitative PCR was performed to measure the mRNA expression of IL-22 in peripheral blood mononuclear cells (PBMCs),and enzyme-linked immunosorbent assay (ELISA) to determine the level of IL-22 in sera.Results The relative expression level of IL-22 mRNA in the patients with PR in recovery stage was significantly higher than that in the healthy controls (2.89 ±0.91 vs.1.91 ± 0.60,t =3.84,P ＜ 0.05),but lower than that in the patients in acute stage (2.89 ± 0.91 vs.4.15 ±1.36,t =3.61,P ＜ 0.05).Similarly,the level of serum IL-22 was significantly increased in the patients with PR in recovery stage compared with the healthy controls ((21.44 ± 7.33) vs.(13.22 ± 4.26) ng/L,t =4.49,P ＜ 0.05),and increased in the patients with PR in acute stage compared with those in recovery stage ((36.87 ± 10.63) vs.(21.44 ± 7.33) ng/L,t =5.01,P ＜ 0.05).The level of serum IL-22 was positively correlated with the stage of PR (r =0.883,P ＜ 0.05).Conclusions IL-22 is overexpressed in PBMCs and sera of patients with PR,implying that IL-22 is involved in the pathogenesis of PR.

Objective To observe the pulmonary artery motion curve with anatomical M-mode echocardiography, and to investigate its influential factors. Methods The pulmonary artery motion curve was detected and pulsating amplitude of pulmonary artery wall (PAWPA) was measured with anatomical M-mode echocardiography in 160 patients with normal pulmonary artery pressure. Intraclass correlation coefficient (ICC) was used to assess inter-observer conisitency of PAWPA measurements between two investigators who were blinded to each other's findings, and intra-observer consistency of PAWPA with repeating the measurements on two occasions by the same investigator in 20 randomly selected cases. Stepwise multiple regression was used to analyze the following potential influential factors of PAWPA: age, gender, heart rate, blood pressure, atherosclerosis, right atrial diameter, and pulmonary insufficiency. Results There was good consistency between two independent observers' measurements and between two occasions in the same observer's measurements for PAWPA with ICC values of 0.91 (95% CI, 0.37-0.99) and 0.95 (95% CI, 0.60-0.99), respectively. PAWPA was negatively correlated with age (β=-0.47, P<0.001) and heart rate (β=-0.29, P<0.005). There was no correlation of PAWPA with gender, blood pressure, atherosclerosis, right atrial diameter, and pulmonary insufficiency. Conclusion Anatomical M-mode echocardiography can be used for measuring PAWPA with good consistency and reproducibility. In normal pulmonary artery pressure cases, PAWPA is affected by age and heart rate.

Objective To evaluate the efficacy and safety offlupentixol and melitracen (deanxit) in the treatment on the patients with post-stroke depression.Methods A total of 98 patients of post-stroke depression were randomly divided and assigned to a therapy group and a control group.The two groups was given a routine treatment of stroke.The therapy group was treated with deanxit (52 patients,4 weeks).Both groups were measured by Hamilton rating scale of depression (HAMD),China stroke scale (CSS) and Barthel index(BI)before treatment and after 2 weeks and 4 weeks.Results The efficiency rate in treatment group was much higher than that in control group [86.5％ (45/52) vs.43.5％ (20/26),P ＜ 0.01].HAMD score,CSS score and BI in therapy group were better those in control group 4 weeks after treatment [(9.38 ±1.80) scores vs.(14.56 ± 2.40) scores,(15.79 ± 0.83) scores vs.(28.91 ± 1.02) scores,74.6 ± 15.4 vs.59.2 ± 14.6,P ＜ 0.05].There was obvious untoward reaction in therapy group.Conclusions It is indicated that deanxit can reduce the degree of depression and promote the neurological functional rehabilitation.It is safe and effective in the treatment of post-stroke depression.

Objective The separation of various proteins in urine was used to differentiate the types of urinary protein to determine the site of diabetic kidney damage and lesions. Methods We used sodium dodeeyl sulfonate - agarosegel electrophoresis(SDS - AGE) to detect the unconccntrated urine on 108 cases patients with diabetic nephropathy urine specimens analysis. Results The results of urinary protein electrophoretic of 108 patients displayed: 4 eases for renal tubular proteinuria, 10 eases for physiological proteinuria, 22 eases for glomerular proteinuria, 72 cases for mixed proteinuria. Conclusion Urine protein electrophoresis for diabetic nephropathy patients with positive can distinguish the various components, and to understand the degree of kidney damage and lesions. This method is low -cost, non - invasive and highly sensitive. The film can be stored. It is worthy to be popularized.

Pulmonary arterial hypertension ( PAH) is a progressive lethal vascular disease, which is characterized by pulmo-nary vasoconstriction and vascular remodeling. Recent studies have indicated that the metabolic theory, centered on the loss of mito-chondrial function, plays a key role in the occurrence and development of PAH. This theory links mitochondrial-related changes of ap-optosis-resistance, glycolysis enhancement, mROS decrease and aberrant mitochondrial dynamics to multiple molecular abnormalities, which may provide new ideas for exploring more comprehensive and specific treatment strategies. This article reviews the progresses in mitochondrial abnormality in PAH.