OBJECTIVE:To systematically review the effectiveness and safety of olanzapine in the prevention and treatment of chemotherapy-induced nausea and vomiting(CINV),and provide evidence-based reference for clinical treatment. METHODS:Re-trieved from Medline,PubMed,EMBase,Cochrane Library,Clinical Trials.gov,CBM,CJFD,VIP and Wanfang Database,ran-domized controlled trials (RCT) about olanzapine (test group) versus other drugs or conventional antiemetic regimen (control group)in the prevention and treatment of CINV were collected,Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation by modified Jadad. RESULTS:Totally 19 RCTs were included,involving 1 794 patients. Re-sults of Meta-analysis showed,olanzapine can significantly improve the complete control rate of patients with acute CINV [RR=1.12,95%CI(1.06,1.18),P<0.001],delayed CINV[RR=1.26,95%CI(1.14,1.39),P<0.001],overall CINV [RR=1.62,95%CI (1.32,1.99),P<0.001] and breakthrough CINV[RR=2.05,95%CI(1.47,2.86),P<0.001],there were significant differences be-tween 2 groups;there were no significant differences in the incidence of tiredness,dizziness,lethargy and constipation(P>0.05). CONCLUSIONS:Olanzapine is safe and effective in the prevention and treatment of CINV and can be recommended in treating breakthrough and refractory CINV. Besides,olanzapine in the prevention and treatment of CINV belongs to“off-label use”,so the clinicians should have a comprehensive consideration of chemotherapy and patients’consent.

Objective To study the therapeutic effect and safety of acupuncture a long with the deep respiration on patient of acute traumat ic laryngitis. Methods Totally 240 cases with wind heat syndrome were divided into a treatment group (treated by puncturing acupoint Ka iyin 1 as the main point in combination with deep respiration of the patient) and a control group (treated by gentamy cin sulfate and dexamethasone spray-inhalation). After the treatment for 5 days , both groups were observed on the changes of the symptom scores for congest i on and swelling of vocal cords, sore throat, and hoarseness for evaluating the t herapeutic effect and safety. Results On the 3rd day of treatment, the cured and markedly effective rate of the treatment group was sig nificantly higher than that of the control group (P0.05). There was no untowards finding in l aboratory test. Conclusion Puncturing acupoint Kaiyin 1 as the main point in combination with deep respiration of the patient is a effe ctive and safe treatment for acute traumatic laryngitis.

Objectives:To investigate the morphological characteristics of the lower cervical vertebrae in Chinese Han multilevel cervical spondylotic myelopathy(MCSM)patients and to compare it with European Caucasian MCSM patients.Methods:The MCSM patients who underwent expansive single open-door lamino-plasty(EOLP)between December 2016 and May 2022 at the Affliated Drum Tower Hospital,Medical School of Nanjing University and Clinique Du Parc,France were divided into two groups based on ethnicity.Group A consisted of 80 Chinese Han MCSM patients(42 males and 38 females,mean age 62.3±10.5 years),while group B consisted of 29 European Caucasian MCSM patients(15 males and 14 females,mean age 58.4±12.6 years).The lamina inner width(LIW)at hinge place,lamina outer width(LOW)at hinge place,lamina axis length(LAL)and lamina transverse angle(LTA)of the patients were measured on CT plain scan images before operation.Independent sample t-test was performed to compare the differences in C3-C7 imaging parameters between the two groups.Results:LIW and LOW decreased from C3 to C5,and increased from C5 to C7 in both groups.Group A was significantly smaller in LAL at each level than group B(C3:12.1mm vs 13.4mm;C4:12.5mm vs 13.5mm;C5:12.8mm vs 13.9mm;C6:13.1mm vs 14.4mm;C7:13.5mm vs 14.4mm),while larger in LIW(C3:2.8mm vs 2.4mm;C4:2.4mm vs 1.9mm;C5:2.2mm vs 1.7mm;C6:2.7mm vs 2.3mm;C7:4.1mm vs 3.7mm)with significant differences in C3-C6(P＜0.05).No significant differences were found in LOW and LTA between the two groups at each level(P＞0.05)Conclusions:In Chinese Han and European Caucasian MCSM patients,C5 is the thinnest lamina among the lower cervical vertebrae with the highest risk during grooving in EOLP,and the risk is theoretically higher in Chinese Han MCSM patients than that in Caucasian MCSM patients.