Objective To study the association of peroxisome proliferator activated receptor?2 (PPAR?2) gene polymorphism with type 2 diabetes mellitus.Methods PPAR?2 gene Pro12Ala polymorphism was examined using polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) in 101 couples of type 2 diabetes mellitus normal control.Results In control group, heterozygosity carriers had lower serum apolipoprotein B (P=0 006).The Pro12Ala polymorphism in PPAR?2 gene is not associated with type 2 diabetes mellitus(OR=1.48,95%CI=0.52～4.18,P=0.461).Conclusion PPAR?2 gene Pro12Ala polymorphism is associated with abnormal lipid metabolism; PPAR?2 gene may not play a critical role in the development of type 2 diabetes mellitus in Han of Beijing Chinese.

Objective To explore the clinical features and evaluate the diagnostic methods for adrenal tumors and bilateral adrenal hyperplasia (BAH) before surgical operation.Methods Clinical data of 45 cases with adrenal tumor and BAH were analyzed.Results Of 45 cases,15 were with aldosterone producing adenoma (APA),3 with of BAH,8 pheochromocytoma,4 adrenal tumor with hypercortisolism and 15 adrenal incidentaloma.Conclusions Before operation,endocrine function examinations of adrenal tumors are necessary for preventing preoperational complications.