Objective To observe curative effects of biological amnion transplantation to treat the huge pterygium.Methods 86 eyes were divided into two groups randomly(by random number table).Group A were eyes treated with cutting the pterygium and uncovered sclarel wound.Group B were eyes treated with biological amnion which had been transplanted on scleral wound and all conea after the pterygium had cut.The irritative symptoms,heal time of corneal wound,relapse rate after half year were recorded.Results Its mild irritative symptoms such as foreign body sensation,photophobia and pain in group B were lighter than those in group A(χ2 =6.08,P =0.01,χ2 =31.40, P =0.00,χ2 =14.18,P =0.00).The time of corneal wound heal was 5.21 ±0.89 days in group A and it was (4.02 ± 0.71)days in group B.The statistic was significant(t =6.85,P =0.00).There was no significant difference in relapse rate after half year between group A and group B(χ2 =1.40,P =0.24).Conclusion Biological amnion transplantation can alleviating irritative symptoms and shortening heal time in huge pterygium operation.