1.The application of 18F-FDG PET/CT in thyroid tumor
Chinese Journal of Nuclear Medicine and Molecular Imaging 2016;36(2):192-195
The clinical application of 18F-FDG PET/CT in thyroid tumor is primarily for restaging of patients with DTC but having a negative 131i whole-body scan in the presence of elevated serum Tg and TgAb levels.In parallel with the accumulation of clinical experience and increasing clinical utilization of 18F-FDG PET/CT,the application of 18F-FDG PET/CT in thyroid tumors is also broadened.This review aims at updating the application of 18F-FDG PET/CT in different types of thyroid tumors.
2.Estimation of patient radiation dose and risk from whole body 18F-FDG PET/CT examination
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(7):430-433
Patients are exposed to both the internal radiation from radiopharmaceutical and the external radiation from the X-rays during PET/CT examination. Estimating patients′ radiation dose from whole body PET/CT examination could eliminate their apprehension and give clinical physicians guidance about whether the patients need to perform PET/CT examination. The calculation methods, influencing factors, cancer risk of PET/CT imaging and how to reduce the radiation dose are reviewed in this paper.
3.Transesophageal echocardiographic study of atrial septal thickness and movement
Enkui HAO ; Zhiming GE ; Zhenguang WANG
Chinese Journal of Ultrasonography 2003;0(11):-
Objective To investigate relationship between atrial septal thickness and atrial function by transesophageal echocardiography(TEE). Methods TEE and automatic bound detection (ABD) were performed in 83 consecutive sinus rhythm subjects including four groups: control group, nonrheumatic heart disease group, rheumatic mild mitral stenosis group and rheumatic severe mitral stenosis group. Results Atrial septal thickness(AST)and atrial septal thickness fraction (ASTF) were different in various heart diseases. There was high correlation respectively between left atrial diameter(LAD) and AST(r= -0.601 8 ,P
4.Clinical Investigation on the Antiepilepsia Effect of YuXianLing(YXL)
Jingjing WANG ; Zhenguang LI ; Yuanjiang DENG
Journal of Chinese Physician 2000;0(11):-
0 05).There wasn't side reaction in YXL.Conclusion YXL has better effect of antiepilepsia and resuming consciousness.
5.Hepatic vein occlusion in hepatectomy for liver tumor involving second hepatic hilum
Zhenguang WANG ; Weiping ZHOU ; Mengchao WU
Chinese Journal of Digestive Surgery 2011;10(4):312-314
Hepatic vein hemorrhage and air embolism are easily caused during the resection of the tumor involving the second hepatic hilum.Hepatic vein occlusion has been proven to decrease this risk,while classic selective hepatic vein occlusion with tourniquet is technique demanding.We modified the classic method by using Satinsky clamp in hepatic vein dissection and occlusion.Based on the clinical data of 220 patients who received hepatic vein occlusion with tourniquet and 330 patients with Satinsky clamp,we proved that hepatic vein occlusion with Satinsky clamp is simpler,safer and with high success rate.
6.Detection and Significance of Anti-β2 Glycoprotein 1 Antibodies in Female Infertility and Threatened Abortion
Na LI ; Yang RONG ; Zhenguang WANG
Journal of Modern Laboratory Medicine 2015;(2):42-45
Objective To analysis the correlation of the anti-β2 glycoprotein 1 antibodies in female infertility and threatened a-bortion.Methods Selected 547 patients with female infertility,229 patietns with threatened abortion,229 patietns with ir-regular menses and 31 normal female between August 2013 to January 2014.All the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)were detected by ELISA.Detected the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)of 114 patients who treated with aspirin and prednisone combined with gamma globulin.Results The positive rate of anti-β2GP1 antibodies (Ig-G/Ig-M)of female infertility,threatened abortion,irregular menses and normal female were 0.36%,0.43%,1.6%,0% and 20.29%, 19.21%,8.3% and 3.2%,respectively.The positive rate of aβ2GP1-IgM of female infertility,threatened abortion,irregular menses were higher than normal female.The anti-β2GP1-IgM of the treated female infertility were 47.14± 34.85 RU/ml and 31.14±27.64 RU/ml,respectively.The anti-β2GP1-IgM of the treated threatened abortion were 37.75±31.20 RU/ml and 24.34±24.48 RU/ml,respectively.The levels of anti-β2GP1-IgM of the treated patietns were significantly lower than before.Conclusion There was a close relationship between anti-β2GP1-IgM antibodies and female infertility and threatened abortion,anti-β2GP1-IgM antibodies maybe one of the immune factors for female infertility and threatened abortion.
7.Changes of plasma lysophosphatidic acid and its clinical significance in elderly patients with supratentorial cerebral watershed infarction
Daozhen WANG ; Zhenguang LI ; Yuanchen WANG ; Xianglin CHI
Chinese Journal of Postgraduates of Medicine 2010;33(1):16-18
Objective To study the clinical type and features of cerebral watershed infarction (CWI)in eldedy patients and its relationship with plasma lysophosphatidic acid(LPA).Method Analyzed the clinical data of 106 cases of CWI patients(CWI group)confirmed by cranial MRI,and compared plasma LPA levels in patients with different types of CWI,non-CWI patients(non-CWI group,36 cases)and healthy controls(control group,32 cases).Results In CWI group,anterior-cortex type 22 cases,LPA(4.93±0.72)μmol/L,posterior-cortex type 17 cases,LPA(4.75±0.81)μmoi/L,subcortical type 47 cases,LPA (5.46±1.03)μmol/L,mixed type 20 cages,LPA(6.02±1.12)μmol/L.In non-CWIgroup,LPA(5.37±1.24)μmol/L.In control group,LPA(2.92 ±0.36)μmol/L.The levels of LPA significandy increased in various types of CWI(P<0.05 or<0.01).of which mixed type and subcortical type were the highest,and the level of LPA in mixed type WaS higher than that in anterior-cortex type and posterior-cortex type(P<0.05).The level of LPA in non-CWI group was higher than that in control group,but there wss no significant difference compared with various types of CWI.Conclusions Subcortical type is the primal type in elderly CWI patients,the main cause of which is the atherosclerotic plaque formation and lumen stenosis.Platelet activation and its microemboli play an important role in the pathophysiology.LPA levels are significantly higher in various types of CWI,of which mixed type is the highest.LPA can be used as an important molecular marker to guide the sub-type treatment of CWI in elderly patients.
8.Sleep disorders in patients w ith ischemic stroke:pathophysiological mechanisms and treatment
Zhaoyang YAN ; Zhenguang LI ; Pengfei WANG ; Yong ZHANG ; Jiangshan ZHANG
International Journal of Cerebrovascular Diseases 2016;24(11):1039-1044
Sleep disorder is a common complication after is chemicstroke.If it is nottimely diagnosed and treated, it may affect the rehabilitation of stroke and recurrence. The manifestations of sleep disorders have various forms according to the different locations of infarction. For the treatment of sleep disorder after stroke, the method of the combination of drugs and physical therapy is used in clinical practice at present. In recent years, w ith the w idely use of the polysomnography, poststroke sleep disorders can be diagnosed clearly and carefuly. The treatment for sleep disorders after stroke may significantly improve the prognosis of patients.
9.Antiplatelet therapies in ischemic stroke patients with diabetes mellitus or insulin resistance
Zhenguang LI ; Tong WANG ; Jinbiao ZHANG ; Xinghua CUI ; Jiangshan ZHANG
International Journal of Cerebrovascular Diseases 2016;24(10):930-935
Diabetes mellitus is an independent predictor of high platelet reactivity after antiplatelet therapy in patients with ischemic stroke,and the latter is closely related to the increased risk of recurrence of stroke.The mechanisms of high platelet reactivity in patients with diabetes or insulin resistance are associated with a variety of factors.Some circulating molecules can be used as markers for predicting the reactivity of platelets.Monitoring of platelet reactivity after treatment with new antiplatelet agents may provide basis for individualized antithrombotic therapy in ischemic stroke patients with diabetes or insulin resistance.
10.Content Determination of Notoginsenoside R1, Ginsenoside Rg1 and Rb1 in Shuxuening Capsules by HPLC
Daohai CHENG ; Jie WANG ; Hua LU ; Zhenguang HUANG
China Pharmacist 2015;(11):1978-1980
Objective:To determine the content of notoginsenoside R1 , ginsenoside Rg1 and Rb1 in Shuxuening capsules. Meth-ods:The three constituents were determined on a Hypersil ODS-2 C18 column (250 mm × 4. 6 mm, 5 μm) with gradient elution using acetonitrile (A) -aqueous solution (B) (0-8 min, 20%A→20%A, 8-40 min, 20%A→30%A, 40-60 min, 30%A→45%A) at the detection wavelength of 203 nm with a flow rate of 1. 0 ml·min-1 . The column temperature was 25℃ and the injection volume was 20μl. Results:The calibration curve showed good linearity within the concentration range of 0. 05-0. 50 mg·ml-1 for notogisenoside R1 , and 0.20-2.00 mg·ml-1 for ginsenoside Rg1 and Rb1(r =0.999 9). The average relative recovery was 98.79%, 98.42% and 98. 89% for each constituent(RSD=0. 85%, 0. 97% and 0. 74%, respectively, n=6). The intra-day RSD was 0. 49%, 0. 20% and 0. 39%, and the inter-day RSD was 0. 75%, 0. 56% and 0. 51%, respectively. The RSDs of stability test and repeatability test were less than 1%. Conclusion:The method is simple with good accuracy and repeatability, which can be used for the determination of no-toginsenoside R1 , ginsenoside Rg1 and Rb1 in Shuxuening capsules.