Objective: The clinical experience of treatment in 38 patients of Reinke′s edema by surgery of minimally invasive was reported from June 1997 to December 2000. Methods: Thirty-eight patients (25 males and 13 females, ranging in age from 46 to 67 years old) with Reinke′s edema of vocal cord were diagnosed by frequency-flash-laryngoscope and pathologic. The bilateral vocal cord stripping surgery with micro-suspension laryngoscope under general anaesthesia was completed in all 38 patients. Results: After treatment 3 months to 1 year follow-up in 33 cases, 27 cases(81.8%) had acquired good voice and only 6 cases (18.2%) had acquired lower tone voice. Conclusion: None of them had vocal cord adhesive with bilateral vocal cord mucous stripping operation which remained anterior 1/2 parts of vocal cord mucous on one side.

AIM:To investigate pharmacokinetics of cinnamon acid and paeonol in Jinkui Shenqi Pill(Radix Rehmanniae Praeparata,Cortex Cinnamomi,Radix Aconiti Lateralis praeparata,Rhizoma Alismatis,etc.)in rabbit.METHODS:RP-HPLC was used to examine blood concentration of cinnamon acid and paeonol in rabbit which was administred Jinkui Shenqi Pill.Chromatographic condition consisted of Symmetry C_ 18(5?m,3.9 mm ?150 mm)chromato graphic column,mobile phase(methanol-1%glacial acetic acid water-solution(45∶55)),flow rate(0.8 mL/min),column temperature(35 ℃),detection wavelength of cinnamon acid(285 nm),detection wave length of paeonol(274 nm).The serum pharmacokinetic parameters were calculated with 3p87 program.RESULTS:Linear range of cinnamon acid ranged from 0.06 ?g/mL to 15 ?g/mL(r=0.999 7),the lowest detectability was 0.054 ?g/mL.Pharmacokinetic process of paeonol in rabbit could be fitted to two-compartment model;Linear range of paeonol ranged from 0.2 ?g/mL to 10 ?g/mL(r=0.999 9),the lowest detectability was 0.02 ?g/mL.Pharmacokinetic process of cinnamon acid in rabbit could be fitted to one-compartment model.CONCLUSION:HPLC detection of serum concentration of cinnamon acid and paeonol is simple,rapid,highly accurate and sensitive.Pharmacokinetic parameters can reveal pharmacokinetics of cinnamon acid and paeonol of Jinkui Shenqi Pill in rabbit.