ObjectiveTo investigate the clinical value of G5 Percussive Mobilizer in respiratory failure.Methods76 patients with respiratory failure were randomly divided into the treatment group (38 cases) and control group (38 cases). The treatment group were treated with G5 Percussive Mobilizer made in America,and the control group were treated with knock expectoration. The daily sputum volume, clinical symptoms, thoracic signs and arterial blood gas analysis changes were observed. ResultsThe daily sputum volume,clinical symptoms,thoracic signs and arterial blood gas analysis changes of the treatment group (31 cases effective,81.6% ) has significant difference compared with the control group (23 cases effective ,60.5% ) ( P < 0. 05 ). ConclusionG5 Percussive Mobilizer can eliminate the bronchial secretion rapidly and effectively,and it can help improve the ventilation and oxygenation function. It is safe, effective and easy to practice in bronchial purification treatment.