Hemangiosarcoma ; pathology ; Humans ; Liver Neoplasms ; pathology ; Lung Neoplasms ; secondary ; Male ; Middle Aged ; Pelvic Neoplasms ; secondary ; Spinal Neoplasms ; secondary ; Splenic Neoplasms ; secondary

Objective To explore the role of tumor necrosis factor (TNF-?) and endotoxin(LPS) in upper gastrointestinal bleeding in cirrhosis patients and the preventive and treatment mechanism of rhubarb. Methods 45 liver cirrhosis patients with upper gastrointestinal bleeding were treated with rhubarb, and its efficacy was compared with cemetidine's efficacy. Liver function, and serum levels of TNF-? and LPS were measured before and after the therapy. Results Patients’symptoms and liver function were improved, and serum levels of TNF-? and LPS significantly decreased after treated with rhubarb. Conclusions TNF-? and endotoxin might play an important role in upper gastrointestinal bleeding in cirrhosis patients. Rhubarb has protective and treatment effect on upper gastrointestinal bleeding in cirrhosis patients by reducing TNF-? and LPS release.

BACKGROUND:The studies regarding reference values of fraction excretion of uric acid(FEUA)is poorly understood.OBJECTIVE:To establish reference values of FEUA in healthy adults in Qingdao area.DESIGN,TIME AND SETTING:The investigation and analysis was performed at the Qingdao Medical College from August 2007 to August 2008.PARTICIPANTS:A total of 581 healthy adults with aged 20-70 years,including 279 male and 302 female stayed in Qingdao more than 5 years were selected from August 2007 to August 2008.The adults were divided into groups according to the ages.There were 61 adults in the group aged 21-30 years(32 male and 29 female);92 adults in the group aged 31-40 years(40 male and 52 female);173 adults in the group aged 41-50 years(82 male and 91 female);169 adults in the group aged 51-60 years(88 male and 81 female);and 86 adults aged more than 60-year-old(37 male and 49 female).METHODS:The uric acid and creatinine of fasting blood and 12 h urine taken and tested with Sysmex chemix-180 to calculate FEUA,the results were statistically analyzed by SPSS 16.0 software.MAIN OUTCOME MEASURES:①Comparison of general information and biochemical index.②Comparison of serum uric acid,FEUA in sexes and reference values of FEUA.③Comparison of serum uric acid,FEUA in different age groups.RESULTS:Serum uric acid in male was higher,but FEUA was lower than that of female,there were significant difference between different genders(P 0.05).The normal range of FEUA in female and male was 4.039%-10.613% and 3.447%-9.915%,respectively.CONCLUSION:The reference value of FEUA in healthy adults in Qingdao is preliminarily established.To provide evidence for hyperuricemia control and prevention,it is necessary to establish respective reference values of FEUA and prompting the excretion of uric acid for healthy male and female.

Adolescent ; Adult ; Alanine Transaminase ; blood ; DNA, Viral ; analysis ; Female ; Hepatitis B Surface Antigens ; blood ; Hepatitis B e Antigens ; blood ; Hepatitis B, Chronic ; blood ; drug therapy ; Humans ; Interferon Type I ; therapeutic use ; Interferon-alpha ; therapeutic use ; Liver Function Tests ; Male ; Middle Aged ; Recombinant Proteins ; Treatment Outcome

Macrophages have strong plasticity and heterogeneity,and can undergo functional transformation in response to different signal stimuli,such as classical activation of M1 type(M1 type polarization)and selective activation of M2 type(M2 type polarization).The pathways of macrophage M1/M2 polarization are quite extensive,involving nuclear factor-κB(NF-κB)/mitogen-activated protein kinase(MAPK)signaling pathway,interleukin-4(IL-4)/signal transduction and activator of transcription 6(STAT6)signaling pathway,Notch signaling pathway,Wnt/β-catenin signaling pathway,etc.At the same time,M1/M2 polarization of macrophages is also regulated by exosomes,metabolites,non-coding RNA,electrical stimulation,probiotics,etc.,and its imbalance is closely related to the occurrence and development of different types of liver disease.In this paper,the mechanism of its polarization was reviewed,and it was found that M1 polarization of macrophages played a promoting role in the process of liver tissue injury,inflammation and fibrosis,while M2 polarization of macrophages played the opposite role.Among them,hepatocellular carcinoma,as the advanced stage of chronic liver disease,was characterized by increased M2 polarization and impaired M1 polarization of macrophages.Therefore,this paper pays attention to the role of M1/M2 polarization of macrophages in different types of liver diseases,in order to better establish the targeted therapy of macrophage subsets.

Objective To explore the relationship between the polymorphisms of the primary gout predisposing gene (BCAS3) rs11653176 locus and the incidence of gout in Han Chinese men in coastal areas of Shandong Province. Methods One hundred and fifty-two cases of patients with gout remission,68 cases of acute stage,252 patients with hyperuricemia, and 280 healthy subjects, total males, were enrolled. Genotyping the rs11653176 locus of BCAS3 gene by TaqMan probe technique. The expression level of BCAS3 gene mRNA in each PBMC was measured by RT-qPCR. The levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and interleukin-18(IL-18)in serum were measured by ELISA. Results The change of allele frequency of rs11653176 locus in BCAS3 gene was associated with gout(P<0.01). BCAS3 mRNA in patients with gout was significantly higher than that of healthy people and patients with hyperuricemia(P<0.01). In gout patients, the expression level of BCAS3 gene containing C allele was higher than that of T allele(mRNA,P<0.05). The inflammatory factors in the acute phase of gout were significantly higher than those in phases of remission and hyperuricemia(P<0. 01). Conclusion Changes in the allele frequency of BCAS3 alleles rs11653176(high C, low T)may contribute to the expression of this gene,and lead to gout. And the onset of gout is closely related to the production of inflammatory factors.

Objective: To realize the efficient monitoring of frequency of medical exposure and dose monitoring in Ningbo by means of informatization. Methods: Data transmission process and the key elements of frequency of medical exposure and individual dose were investigated. According to standardization principles of data elements, the standardized data elements for frequency of medical exposure and individual dose were determined. On this basis, modules and functions of data receiving platform on the frequency of medical exposure and individual dose in Ningbo were designed. Results: Totally 59 data elements on frequency of medical exposure and individual dose were formed. According to their functions, the data receiving platform was divided into the distribution of radiodiagnosis and radiotherapy resources, the frequency monitoring of medical exposure and dose monitoring for permanent residents, and the dose monitoring. Conclusions The establishment of frequency and dose information monitoring platform on medical exposure in Ningbo and the determination of standardized data elements will be conducive to further progress in medical exposure information monitoring in Ningbo.