objective To investigate the effect of the prognosis of multiple organ dysfunction syndrome(MODs) through APACHE Ⅱ and APACHE Ⅲ.Methods The relations of APACHEⅡ,APACHEⅢ,the occurrence rate and number of organs failure and the dangerous extent and prognosis of MODS are studied between survival group and death group through the review research of 45 cases of MODS.Results APACHE Ⅱ andⅢ,age and genrating rate of failure organS are significant difference between surviral group and death group(P＜0.05)in MODS.The predicting correlation of APACHE Ⅱis not significant difference between number of organs failure and mortality of MODS(P＞O.05),but the predicting correlation of APACHE Ⅲ is significant difference between number of organs failure and mortality of MODS(P＜0.05).Conclusion The study showed APACHEⅢis better than APACHEⅡ on the dangerous extent and prognostic evaluation in MODS.