1.Diagnosis and surgical treatment for patients suffering from thoraco-abdominal injuries
Chinese Journal of General Surgery 2001;0(09):-
Objective To sum up the experiences of early diagnosis and surgical treatment of thoraco abdominal injuries. Method The clinical material in 65 cases of thoraco abdominal injuries treated from 1990 to 1998 was retrospectively reviewed. Result Thoracic explorations and closed thoracic drainage and abdominal operations were carried out in 15 cases and in 50 cases respectively. 65 cases were cured and 3 cases (5%) died of large cardiac blood vessel injuries and excessive blood loss. Conclusion The thoraco abdominal injuries are of very critical illness, it′s important to make early dignosis,promt and proper surgical operation.Meanwhile,active antishock measures, postoperative complication prevention, critical care for the patients are also very important for a better prognosis.
2.Simultaneous determination of ephedrine and pseudoephedrine in Zhisou Lixiao Oral Liquid by HPLC
Hongjuan CHENG ; Tingli QU ; Ruilin LIU ; Xicheng ZHANG ; Zhengbao ZHAO
Chinese Traditional Patent Medicine 1992;0(02):-
AIM:To set up a method of simultaneously determining the contents of ephedrine and pseudoephedrine in Zhisou Lixiao Oral Liquid (Herba Ephedrae, Radix et Rhizoma Glycyrrhizae, Semen Raphani, etc). METHOD: The HPLC-quantitative analysis was carried out on a column of Sinochrom ODS-BP by using a mobile phase of acetonitrile-0.02 mol/L potassium dihydrogen phosphate (pH=2.7), (4∶100, with 0.1% triethylamine) under a flow rate of 1.5 mL/min. 207 nm was selected as the wavelength of detector. RESULTS: The linear range of ephedrine was 20.8-208.0 ?g/mL(r=0.999 7) and pseudoephedrine's was 15.0-150.0 ?g/mL(r=0.999 8). The recoveries of them were all between 95% and 105%(RSD
3.Study on the correlation between sleep disorders and the site of injury after traumatic brain injury
Zhengbao ZHANG ; Chuan QIN ; Yi YAN ; Baicheng LI ; Biao ZHANG ; Jiangang HU ; Xiujiang YANG
Chongqing Medicine 2015;(9):1206-1207,1210
Objective Research on traumatic the related factors of sleep disorder after traumatic brain injury ,in order to pro-vided the rationale for the diagnosis and treatment .Methods The SPIEGEL was used to evaluate the traumatic brain injury patients who were hospitalized .Recording time in sleep disorders in 3 months .Analysis the relations between the sleep disorders and brain injury site by combining with the patients head CT and MRI .Results Seen in 200 cases of patients with sleep disorders of 105 cases (52 .5% );71 cases appeared in patients within 1 week after waking ,accounted for 76 .19% ;The brain stem ,frontal lobe and basal ganglia injury occurred sleep disorders were more likely(66 .7% ,64 .0% ,70% ) .The difference was statistically significant(P<0 .05) .Conclusion Sleep disorder is a common clinical symptom of mild traumatic brain injury .a time to focus on the patients with-in 1 week after waking ,and closely related to brain stem ,frontal lobe and basal ganglia injury .
4.Study on polysomnography in patients with sleep disorder induced by traumatic frontal lobe injury
Chuan QIN ; Yi YAN ; Baicheng LI ; Zhengbao ZHANG ; Wei DENG ; Jiangang HU ; Xiujiang YANG
Chongqing Medicine 2015;44(12):1633-1634,1637
Objective To explore the abnormal changeof the polysomnography(PSG) in the patientwith traumatifrontal lobe injury .MethodTotally 16 patientwith traumatifrontal lobe injury accompanying sleep disorde(brain traumgroup) and 20 individualof physical examination (control group) were performed the whole nighPSG .ResultCompared with the control group ,the incubative stage of sleep in the brain traumgroup waprolonged ,while the sleep time and slow wave sleep time were shortened .The rapid eye movemen(REM) time and the periodicity of REM had statistical differencebetween the two group,buthe REM incubative stage ,density and intensity of REM had no statistical differencebetween the two goup.Conclusion The changeof PSG in the patientwith traumatifrontal lobe injury are dominated by the extension of the REM time and the shorten-ing of REM periodicity .
5.Therapeutic Observation of Acupuncture in Treating Vertebrobasilar Ischemia
Shiyou WANG ; Hailiang QIAN ; Ruo DU ; Xinling ZHANG ; Zhengbao ZHOU ; Xu JIANG
Shanghai Journal of Acupuncture and Moxibustion 2015;(9):818-821
Objective To observe the clinical efficacy of acupuncture at the nine acupoints on nape in treating vertebrobasilar ischemia (VBI). Methods Totally 100 VBI patients were randomized into a treatment group and a control group, 50 in each group. The treatment group was intervened by acupuncture at Fengfu (GV 16), Fengchi (GB 20), Wangu (GB 12), Tianzhu (BL 10), and Jiaji (EX-B 2, C3);while the control group was by oral administration of Nimodipine tablets. The parameters in Transcranial Doppler (TCD) and Dizziness Assessment Rating Scale (ADRS) were observed before and after intervention, and the clinical efficacies were compared. Results The TCD parameters were significantly changed in the treatment group after intervention (P<0.05). The TCD parameters [Vs (RVA), Vd (BA, LVA), Vm (BA, RVA), PI (BA)] were significantly changed in the control group after intervention (P<0.05). After intervention, there were significant differences in comparing the TCD parameters [Vs (BA, LVA, RVA), Vd (BA, RVA), Vm (BA, LVA), PI (BA)] between the two groups (P<0.05). The DARS average scores were significantly changed in both groups after 7-day treatment (P<0.01). The DARS average scores after the whole intervention were significantly different from that after 7-day treatment in both groups (P<0.01). There were significant differences in comparing the DARS average scores between the two groups after 7-day intervention and after the whole intervention (P<0.01). The recovery-markedly effective rate and total effective rate were respectively 76.0%and 98.0%in the treatment group versus 44.0%and 96.0%in the control group, and there was a significant difference in comparing the recovery-markedly effective rate (P<0.05). Conclusions Acupuncture at the nine nape acupoints is an effective method in treating VBI.
6.Expression and significance of IGF-1 and GFAP in serum of glioma patients
Zhengbao ZHANG ; Biao YANG ; Chuan QIN ; Baicheng LI ; Shuang SHI ; Bei LIU
International Journal of Laboratory Medicine 2018;39(11):1297-1299
Objective To explore the expression and significance of insulin grow th factor 1(IGF-1) and gli-al fibriuary acidic protein(GFAP) in patients with glioma .Methods The serum levels of IGF-1 and GFAP in 40 glioma patients ,30 healthy subjects and 35 patients with other benign intracranial tumors were measured by double antibody sandwich method .Results There was no significant difference in serum IGF-1 and GFAP lev-els between healthy subjects and other benign intracranial tumor patients (P>0 .05) ,and the levels of IGF-1 and GFAP in the serum of glioma patients were significantly higher than those of healthy and other benign in-tracranial tumor patients (P<0 .05) .The serum levels of IGF-1 and GFAP in glioma patients after operation were significantly lower than those before operation (P< 0 .05) .Conclusion The expression of IGF-1 and GFAP in the serum of glioma patients is significantly higher than those of healthy subjects and other benign intracranial tumor patients .It has good sensitivity and specificity .It can be used as a serum marker of glioma patients and has certain clinical value .
7. Epidemic trend of corona virus disease 2019 (COVID-19) in mainland China
Zhengbao ZHU ; Chongke ZHONG ; Kaixin ZHANG ; Chen DONG ; Hao PENG ; Tan XU ; Aili WANG ; Zhirong GUO ; Yonghong ZHANG
Chinese Journal of Preventive Medicine 2020;54(0):E022-E022
Objective:
In order to master the epidemic trend of corona virus disease 2019 (COVID-19) and evaluate the effect of prevention and control, we evaluate the epidemic dynamics of COVID-19 in mainland China, Hubei province, Wuhan city and other provinces outside Hubei from January 16 to February 14, 2020.
Methods:
We collected the daily number of new confirmed COVID-19 cases by nucleic acid detection reported by the National Health Commission from January 16, 2020 to February 14, 2020. The analysis includes the epidemic curve of the new confirmed cases, multiple of the new confirmed cases for period-over-period, multiple of the new confirmed cases for fixed-base, and the period-over-period growth rate of the new confirmed cases.
Results:
From January 16 to February 14, 2020, the cumulative number of new confirmed cases of COVID-19 in mainland China was 50 031, including 37 930 in Hubei province, 22 883 in Wuhan city and 12 101 in other provinces outside Hubei. The peak of the number of new confirmed cases in other provinces outside Hubei was from January 31 to February 4, 2020, and the peak of new confirmed cases in Wuhan city and Hubei province was from February 5 to February 9, 2020. The number of new confirmed cases in other provinces outside Hubei showed a significant decline (23% compared with the peak) from February 5 to February 9, 2020, while the number of new confirmed cases in Wuhan city (30% compared with the peak) and Hubei Province (37% compared with the peak) decreased significantly from February 10 to February 14, 2020.
Conclusion
The epidemic prevention and control measures taken by the state and governments at all levels have shown very significant effects, effectively curbing the spread of the COVID-19 epidemic in China.
8. The relationship between histone H3Ser10 phosphorylation and DNA damage in periphery blood lymphocytes of polycyclic aromatic hydrocarbons exposed workers
Fangping WANG ; Xiaonian ZHU ; Zhengbao ZHANG ; Liping CHEN ; Junling FAN ; Qingye LI ; Shen CHEN ; Wen CHEN
Chinese Journal of Preventive Medicine 2017;51(5):421-426
Objective:
To investigate the effect of polycyclic aromatic hydrocarbons (PAHs) exposure on the level of histone H3Ser10 phosphorylation (p-H3S10) and DNA damage degree in peripheral blood lymphocyte (PBLCs).
Method:
75 coke oven workers from Benxi steel plant in Liaoning Province of China (PAHs-exposed group) and local 50 hot rolling workers (control group) were recruited in this study with age, working years, labor intensity and high temperature for matching factors using cluster sampling method in 2014. HPLC-fluorescence was performed to determine the level of urinary 1-hydroxypyrene (1-OHP), DNA damage and specific histone modification were measured in PBLCs of the subjects through comet assay and ELISA assay, respectively. Linear regression model analysis was used to analyze the differences among PAHs exposure, DNA damage and p-H3S10 level in two groups. The Mediation analysis was used to analyze the regulated relationships between urinary 1-OHP, DNA damage and histone modification through the bootstrap method.
Results:
Age of the control and the exposed group were (45.32±8.32) and (43.87±5.67) years old (
9.The advance of model of action in low-dose chronic benzene exposure induced hematotoxicity.
Chen GAO ; Zhengbao ZHANG ; Liping CHEN ; Wen CHEN ; Email: CHENWEN@MAIL.SYSU.EDU.CN.
Chinese Journal of Preventive Medicine 2015;49(9):840-843
Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.
Benzene
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toxicity
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Carcinogens
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toxicity
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Epigenesis, Genetic
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Humans
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Occupational Exposure
10.Association of systolic blood pressure after discharge and the risk of clinical outcomes in ischemic stroke patients with diabetes: a cohort study.
Pinni YANG ; Zhengbao ZHU ; Shuyao WANG ; Mengyao SHI ; Yanbo PENG ; Chongke ZHONG ; Aili WANG ; Tan XU ; Hao PENG ; Tian XU ; Xiaowei ZHENG ; Jing CHEN ; Yonghong ZHANG ; Jiang HE
Chinese Medical Journal 2023;136(22):2765-2767