Mesenchymal stem cells (MSCs) are a group of stem cells derived from mesodermal mesenchyme.They can be recovered from a variety of tissues,including bone marrow,umbilical cord tissue,umbilical cord blood,peripheral blood,and adipose tissue.Under given conditions,MSCs can differentiate into bone,fat,nerve cells,bepatocytes,and many other cells.Thus,MSCs can be used as a new treatment to substitute for organ transplantation.In recent years,the incidence of end-stage liver disease has been increasing and liver disease has become one of the major diseases affecting human health.Donor scarcity and immunological rejection limit the clinical application of liver transplantation.Numerous studies have confirmed the therapeutic effects of MSCs on hepatic fibrosis,cirrhosis,and other liver diseases,which may be related to the differentiation of MSCs into functional hepatocytes.This paper reviews the capacity,regulation,and molecular mechanism of MSC differentiation,and it discusses the therapeutic effects of different sources of stem cells for liver fibrosis.

Objective To investigate the influence of different doses of flurbiprofen axetil on neurological behavior in CCI rats.Methods All SD rats were randomly assigned to 3 groups:control group(C group),operation but without CCI,n=5;CCI group,without injection,n=5;flurbiprofen axetil (FA) group,different doses of flurbiprofen axetil were intraperitoneally administered every 12 hours for 7 days beginning on postoperative 6 hours in CCI rats (FA1 group:2mg/kg,FA2 group:4mg/kg,FA3 group:8mg/kg,FA4 group:16mg/kg),5 rats in each subgroup.The thermal withdrawal latency(TWL) and mechanical withdrawal threshold(MWT) were tested on preoperative 1,3,5 and 7 days and postoperative 1,3,5 and 7 days.Results Firstly,compared with C group[TWL:(12.396±1.144)s;MWT:(12.801±0.494)g],the TWL and MWT of CCI and FA groups[TWL:(5.645±1.144)s,(5.901±0.914)s,(6.300±0.835)s,(7.631±0.597)s,(7.894±0.526)s;MWT:(5.14±0.71)g,(5.28±0.60)g,(6.74±0.50)g,(6.74±0.25)g,(6.70±0.42)g]were significantly declined after surgery (tTWL=26.973,31.047,31.176,30.373,30.772;tMWT=44.192,48.132,51.136,54.326,46.937,all P<0.05),and the TWL and MWT of FA groups significantly improved with the doses from 2mg/kg to 16mg/kg of flurbiprofen axetil[TWL:the minimum (5.030±0.240)s,the maximum (8.300±0.430)s;MWT:the minimum (4.56±0.14)g,the maximum (7.11±0.20)g].Secondly,there were no statistically significant differences in TWL and MWT between CCI group and FA1 group(all P>0.05).However,the TWL and MWT of FA2 group,FA3 group and FA4 group[TWL:(6.300±0.835)s,(7.631±0.597)s,(7.894±0.526)s;MWT:(6.74±0.50)g,(6.74±0.25)g,(6.70±0.42)g] increased significantly compared with CCI group(tTWL=-3.768,-11.569,-13.867,tMWT=-3.898,-15.233,-14.801,all P<0.05).Thirdly,there were no statistically significant differences in TWL and MWT between FA3 group and FA4 group (all P>0.05).Conclusion Over 4mg/kg of flurbiprofen axetil can significantly reduce the thermal hyperalgesia and mechanical allodynia in CCI rats,however,there is a ceiling effect of flurbiprofen axetil,and the dosage of 8mg/kg can provide a maximum analgesic effect.

With the development of magnetic resonance (MR) technology, the concern is focused on molecular and physiological imaging besides structural information. Ultra high field MR scanner shows great superiority. 3. 0-T MR scanners provide almost two-fold signal-to-noise ratio (SNR) compared with a standard 1. 5-T MR scanner. The higher baseline SNR can be converted into a variety of alternative benefits. There are still some other changes brought about by 3. 0-T, such as higher sensitivity to motion, susceptibility effect, more difference in resonant frequency among different metabolites, and so on. These features may be a double-edged sword in structural and functional imaging. But with the ceaseless progress of the technology and gains in experience, 3. 0-T systems will provide more information and show more advantages.
Animals ; Humans ; Image Enhancement ; methods ; Magnetic Resonance Imaging ; instrumentation ; methods ; Magnetic Resonance Spectroscopy ; instrumentation ; Sensitivity and Specificity

Objective To study the clinical features of cardiac arrest patients and the influence factors of effective resuscitation. Methods The clinical data of 76 patients in our hospital who underwent cardiac arrest and resuscitation were analyzed retrospectively. Results The effective resuscitation were observed in forty-seven patients (47/76, 61.8%), 28 patients completely survived(28/76,36.8%), and the total death rate was 63.2%. The successful rate of resuscitation was positive relation to the starting time of resuscitation, the way of cardiac arrest, and the structure and function of heart, but was negative relation to the times of cardioversion. The successful rate of resuscitation had indefinite relation with the patients age and gender. Conclusion The immediate cardioversion was the key factor of successful resuscitation.The successful resuscitation was dependent on the continuous and effective cardio-press. Basical cardio-disease was the major factor affecting prognosis.

Environmental Health ; Occupational Health ; Social Responsibility

Environmental Pollution ; prevention & control ; Metals, Heavy

Chronic Periodontitis ; diagnosis ; diagnostic imaging ; therapy ; Dental Scaling ; Follow-Up Studies ; Furcation Defects ; diagnosis ; diagnostic imaging ; therapy ; Gingival Hyperplasia ; diagnosis ; diagnostic imaging ; therapy ; Humans ; Male ; Middle Aged ; Periodontal Index ; Radiography, Panoramic ; Root Canal Therapy ; Tooth Loss ; diagnosis ; diagnostic imaging ; therapy ; Tooth, Artificial

The occupational hazards to nurses are important factors which may influence the physical and mental health of nurses, and further more influence the quality of care the nurses providing to patients. This article reviewed the occupational hazards to nurses and the related factors in organizational environments and nursing human resources, so as to provide references for further studies and evidence for taking measures to prevent occupational hazards to clinical nurses.

The important role of nursing work environment has received much attention in the management of nursing workforce and the quality of health care services. This paper analyzed current studies on nursing work environment, and suggested that the government and hospital administrators pay more attention to the development of nursing workforce, adequate clinical nurse staffing levels and promoting healthy work environment for nurses.

Aim To investigate the effect of genistein ( GEN) against Aβ( 25 -35 )-induced PC12 cells in regulation of Fas pathway through the activation of JNK. Methods Aβ( 25 -35 )-induced PC12 cells model was established. MTT and fluorescence activated cell sorting to analyze cell viability and apoptotic rate. Fluorescence quantitative PCR was used to detect Fas apoptotic pathways related gene Fas, FasL, caspase-3 and caspase-8 mRNA relative expression. Spectropho-tometry was used to detect caspase-3 and caspase-8 en-zyme activity. Western blot was adopted to detect JNK and p-JNK protein expression level changes. Results GEN attenuated Aβ( 25-35 )-induced upregulation of Fas and FasL, caspase-3 and caspase-8 mRNA lev-el, caspase-3 and caspase-8 enzyme activity, and sig-nificantly reduced Aβ(25-35) induced JNK phospho-rylation level. Conclusion GEN can protect PC12 cells from Aβ(25-35)-induced apoptosis via reducing Aβ( 25 -35 )-induced phosphorylation of JNK activa-tion, and then inhibit the JNK dependent Fas apoptotic pathway.