Histone acetylation and deacetylation is an important regulatory way of gene expression in eukaryotic cells. As a key regulatory enzyme, histone deacetylase is overexpressed in many malignant tumors, including hepa- tocellular carcinoma. In addition, it has been suggested to be a potential therapeutic target for solid tumors. In this study, we review the classification, mechanisms, as well as the expression and regulation of histone deactylases in hepatocelhlar carcinoma.

Expansive type of hepatocellular carcinoma (HCC) is a subtype of HCC. Correlation between the preoperative sonography and postoperative pathology was studied in 35 cases of HCC. According to the classification of nakashima, 21 cases belonged to the expansive type whereas the other 14 cases the infiltrative type. Different from the infiltrative type. the expansive type of HCC had four specific sonographic appearances: hypoechoic ring, hypoechcic halo, pedunculated and small nodular echo which had different pathological bases. Expansive tyje of HCC was not so commonly seen as infiltative type but its rate of surgical resection was mu~h higher than that of infiltratine type (JP< 0. 01). Thus, it is the kind of HCC with significant clinical importance. Preoperative ultrasonographic diagnosis help to decide the way of treatment.

ObjectiveTo investigate the clinical effect of three-dimensional conformal radiotherapy simultaneously combined with XELOX program(oxaliplatin +capecitabine) for local recurrence of esophageal carcinoma after radiotherapy.MethodsSixty patients with local recurrence of esophageal carcinoma after radiotherapy were divided by random digits table method into treatment group and control group with 30 cases each.The patients in treatment group were treated with three-dimensional conformal radiotherapy simultaneously combined with XELOX program chemotherapy.While control group received three-dimensional conformal radiotherapy.The efficacy between two groups were compared.ResultsThe complete remission rate and efficiency rate in treatment group were significantly higher than those in control group [ 53.3％ (16/30) vs.23.3％ ( 7/30 ),86.7％ ( 26/30 ) vs.63.3％ (19/30) ] ( P ＜ 0.05 ).The 1,2,3-year survival rate and median survival time in treatment group were 65.5％,44.8％,34.5％ and 24.8 months,which were significantly higher than those in control group (48.3％,41.4％,6.9％ and 12.1 months)(P ＜0.01 ).The incidences of radioactive esophagitis,radioactive pneumonia and thrombocytopenia in treatment group were higher than those in control group,but there were no statistical differences between two groups (P ＞0.05).The incidences of nausea,vomiting,leukocyte decrease and anemia in treatment group were significantly higher than those in control group [36.7％(11/30) vs.13.3％(4/30),40.0％(12/30) vs.16.7％(5/30),43.3％( 13/30 ) vs.13.3％(4/30),P ＜ 0.05 ].ConclusionsThree-dimensional conformal radiotherapy simultaneously combined with XELOX program can improve short-term efficacy and long-term survival rate of local recurrence of esophageal carcinoma after radiotherapy.

In this article,we explained the pathogenesis of bony paralysis,‘disharmony between bone and muscle',recorded in Huangdi NeiJing,by researching the dependability between bone and muscle both in traditional Chinese medicine and modem medicine.

ObjectiveTo explore the expression of Smad2 in cervical carcinoma and analyze the clinical significance of Smad2.MethodsThe expression of Smad2 in normal uterus group( NE group,n =61 ) and cervical carcinoma group( CC group,n =53 ) were detected by immunohistochemistry to analyze the significance of Smad2 in the cervical carcinoma.ResultsPositive rate of expression of Smad2 protein in NE group was 39.3％,positive rate was 77.4％ in CC group,statistical difference was found between the two groups(P ＜ 0.01 ).The degree of differentiation of cervical cancer was lower,and the Smad2 positive rate was higher,well-differentiated and poorly differentiated were 52.6％ and 91.2％,respectively,and the difference was statistically significante ( P ＜ 0.01 ) ; The invasion of cancer was higher,and the Smad2-positive rate was higher ≤ 1/2 and ＞ 1/2 were 66.7％ and 91.3％,respectively,and the difference was statistically significante ( P ＜ 0.05 ).ConclusionThe expression of Smad2 was less; Smad2 was related to depth of invasion and degree of differentiation of cervical carcinoma,which could be used as clinical diagnosis and prognostic markers.

Objective To evaluate the preoperative diagnostic procedures and treatment choice of primary tumor of the duodenum (PTD).Method The clinical data of 52 cases with PTD in the last 10 years was analyzed retrospectively.Results The correct diagnostic rate of auxiliary examination was:duodenal endoscopy of 90.5%,air barium double radiography of 80%.Six primary benign tumors of duodenum (PBTD)were resected completely with a 5 year's survival of 100%.Among the 46 cases of primary malignant tumors of duodenum (PMTD),28 cases underwent pancreatoduodenectomy,4 cases received segmental duodenectomy,the remaining 13 cases in which the tumors were unresectable were treated bypass.The resection rate was 69.6% and the 5 years' survival rate was 32.6%.Conclusions Duodenal endoscopy and air barium double radiography are mainstays for the diagnosis of PTD.Segmental duodenectomy and simple tumor resection are curable for PBTD; while for PMTD,the therapy of choice should be pancreatoduodenectomy.

Objective To evaluate the academic level and the popularity of Chinese Journal of Hepatobiliary Surgery.Method According to the information of Chinese Medical Citation Index(CMCI),I statistically analyzed the amount and distribution of the originals in Chinese Journal of Hepatobiliary Surgery cited by the journal included by CMCI.Result The average of original articles cited by other researchers is 2.93,and there are more articles cited than other journal.The authors of these articles are from the 30 province,Beijing Shanghai and Guangdong Province are in the front of Hepatobiliary Surgery research.There are 355 citing journals,and self-citing rate is 11.89%.Conclusion With the unique style and character Chinese Journal of Hepatobiliary Surgery is the main medical core periodical and one of the most important information resourses in the field of Medical Hepatobiliary Surgery in China.

Internet-based tendering makes equipment purchase convenient, rapid, effective, economical and fair. The issues that should be paid attention to are also described.

Objective Comparing the variability of four genes of HCMV in the population and the therapy process of single patient.Methods Using PCR to amplify the four genes and restriction enzyme to validate four fragments, These four genes are UL55,UL57,UL86 and UL122 whose coding products are glycoprotein B,single chain binding protein,main capsid protein and IE pp86 separately. Then we use AD169 to optimize the conditions of PCR and restriction enzyme. then we use these conditions to detect 200 blood specimens. Results The PCR positive rate of UL55 is 12.5% and restriction positive rate is 10.0%, which has marked difference with other 3 gene segments(P

"Resolving,espulsing and tonifying" three methods are the general outline of endotherapy in surgery of TCM.The author of this article thinks that pelvic inflammation and appendagitis can be classified in internal ulcer and vusceral carbuncle,and it can be treated by "Resolving,espulsing and tonifying" three methods.As the general programme of treating female inflammatory aphoria in different periods,the three methods can avoid exfetatio and promote the probability of pregnancy.Resolving method is applied in acute period of inflammatory aphoria,active period of chronic inflammatory and chronic pelvic inflammation when abdominal mass has formed but vital qi is not deficient.The pathologic character in this period is sufficiency of vital qi and excessive of pathogenic qi.Expulsing method is applied in inflammatory aphoria patients whose pathogenic has not been cleared but the vital qi has been harmed,at this time damp heat pathogen poison remain in uterus meridians and the nvital qi has no power to resist pathogen,and whose corporeity is always week and infects pathogen poison which results in the course of diseases being repeated and prolonged.Tonifying method is applied after the resolving and espulsing methods have been used.In this period,damp heat stasis have been cleared,inflammation and inflammatory matters have been absorbed,disease has been improved and patient has had condition to be pregnant.Tonifying method can promote human generative function and improve the possibility of conception.