1.Study on the expression of PCNA protein in pituitary adenoma
Journal of Clinical Neurology 2001;14(3):136-137
Objective To explore the relationship between the protein expression of PCNA and biological behavior science in benignant pituita ry adenoma.Methods The protein expression of PCNA in 58 patien ts with pituitary adenoma were determined by ABC immunohistochemical method.Results The PCNA index was significantly higher in the patients with recurrent pituitary adenomas than in nonrecurrent ones(P<0.05).There was no significantly difference between bleeding and unbleeding group,cystic and noncystic group,large type and unlarge type group(P>0.05 respectively) .Conclusion The protein expressions of PCNA reflected the proli ferative activties of pituitary adenomas, and could be taken as one of the indic ators to evaluate recurrence and prognosis of the tumor.
3.Effects of Trillim tschonskii maxim on microvessels response and anti-oxidation enzyme in burned rats.
Chinese Journal of Applied Physiology 2011;27(4):483-494
Animals
;
Burns
;
drug therapy
;
metabolism
;
physiopathology
;
Drugs, Chinese Herbal
;
pharmacology
;
therapeutic use
;
Female
;
Male
;
Mesentery
;
blood supply
;
Microvessels
;
drug effects
;
physiopathology
;
Phytotherapy
;
Rats
;
Rats, Sprague-Dawley
;
Superoxide Dismutase
;
metabolism
;
Trillium
;
chemistry
6.Relationship between T354P mutation of the human sodium/iodine symporter and congenital hypothyroidism.
Zhen ZHAO ; Sheng-li YAN ; Ping FU
Chinese Journal of Pediatrics 2004;42(6):456-457
Case-Control Studies
;
Child, Preschool
;
Congenital Hypothyroidism
;
DNA
;
genetics
;
Female
;
Humans
;
Hypothyroidism
;
genetics
;
Infant
;
Iodine
;
metabolism
;
Male
;
Mutation
;
Polymerase Chain Reaction
;
Sodium
;
metabolism
;
Symporters
;
genetics
7.Measurements of teeth, dental arch and base bone in Mongolia teenages
Zhen FU ; Weijia FENG ; Yong WANG
Journal of Practical Stomatology 2000;0(05):-
Objective: To obtain the data of dental measurements in healthy Mongolia teenages.Methods: Normal dentognathic models were obtained by cephalometric roentgenography in 56 teenages (30 boys and 26 girls) aged 10~17 years. The width of the tooth crown, the size of the dental arch and dental base bone were measured with a vernier. The measurments were statistically analysed.Results: The tooth crown in boys was wider than that in girls( P 0.05). There was no significant difference in Bolton index and Point index between boys and girls.Conclusion: The dental measurments may be refrences for dental clinic and research.
8.Central role of GRP78 in growth of gastric carcinoma cells
Zhengqi FU ; Hongyan ZHEN ; Lijiang LIU
Chinese Journal of Pathophysiology 2014;33(4):625-628
AIM:To explore the effect of glucose-regulated protein 78 (GRP78) on the gastric carcinogenesis. METHODS:GPR78 expression patterns were examined in 34 specimens from gastric carcinoma patients using the immu-nohistochemistry (IHC) assay, and in 10 specimens using Western blotting analysis .In addition, the expression of GPR78 and cyclin D1 was detected in human gastric cancer cell lines SGC 7901 and SGC7901-H78 (overexpressing GRP78) by Western blotting.RESULTS:By IHC assay, GRP78 was found to be highly expressed in the cytoplasm of gastric carcino-mas as compared with the adjacent non-malignant tissues and corresponding normal tissues .GRP78 expression was positive-ly correlated with gender and histological differentiation (P<0.05), but not with age, tumor stage and lymph node metas-tasis (P>0.05).Furthermore, we found that with the increased expression of GRP 78 in SGC7901-H78 cells, the expres-sion of cyclin D1 was also elevated .CONCLUSION:GRP78 might be a key player to be involved in the growth of gastric cancer.
9.Early effect of extracorporeal shockwave treatment on distraction osteogenesis of long bone in rabbits
Jun FU ; Zheng GUO ; Zhen WANG
Chinese Journal of Orthopaedic Trauma 2002;0(02):-
Objective To investigate the early effect of extracorporeal shockwave(ESW) treatment on distraction osteogenesis of rabbit tibias and its mechanism. Methods 30 adult New Zealand white rabbits were used. After osteotomy of left tibias, improved Orthofix M- 100 bone fixator was applied. After 5 days, bone lengthening of 1 cm was obtained over 10 days. Randomly the animals were divided into ESW and control groups. No ESW treatment was given to the control group. The shock wave was set at 0.54 mJ/mm2 and 1000 shots each time were applied to the central areas in the ESW group. Then the animals were divided into 3 sub- groups, and were killed respectively at 45, 60 and 75 days after osteotomy. During the process, X- ray, bone mineral density (BMD) and histological examinations were conducted for every animal. Results By X- ray and BMD measurements, we found significantly more bone mass increased in the ESW group than in the control group at 45, 60 days after operation (P
10.Semantic Dementia:A Study for a Chinese Patient with Severe Left Temporal Lobe Atrophy
Qihao GUO ; Zhen HONG ; Jianghui FU
Chinese Journal of Clinical Psychology 2000;0(04):-
Objective:To analyze neuropsychological characteristics of a Chinese patient with semantic dementia (SD)。Methods:A patient with SD was selected to finish 11 neuropsychological tests and MRI and XeCT。Results:(1)Selective impairment of semantic memory caused severe anomia, impaired spoken and written single-word comprehension, reduced generation of exemplars on category fluency tests and an impoverished fund of general knowledge; (2)relative sparing of other components of language output and comprehension; normal perceptual skill and non-verbal problem-solving abilities; relatively preserved episodic memory; (3)a reading disorder with pattern of surface dyslexia;(4) radiological investigations (MRI and XeCT) have shown severe left temporal neocortex atrophy.Conclusion:There are similar clinical and neuropsychological characteristics for SD between the Chinese patient and the sample of Western. Selective impairment of semantic memory may bring about by left temporal neocortex atrophy。