The aquatic therapy is a part of comprehensive rehabilitation. Aquatic therapy may benefit the social interaction, stereotyp-ing and motor learning of children with autism, which may associate with the physical and mental mechanism. The programs applied for the autism include game in water, swimming, physical fitness training in water, etc. The assessment tools include scales and video, and so on.

Objective: To explore the effect of aerobic plus resistance training on the intervention of adolescents with moderate mental retardation and to provide reference for healthy development among specific need population. Methods: Totally 29 adolescents with moderate mental retardation, aged 12-17 years from one middle school in Shunde district of Foshan, were divided into intervention group and control group (16/13) with random number table. The intervention group was subjected to aerobic combined resistance exercise for 11 weeks. The control group maintained the original activities. The changes in body composition, muscle strength, cardiorespiratory endurance and balance ability of the two groups of subjects before and after intervention were compared. Results: After the intervention, the intervention group s skeletal muscle (22.90±3.63)kg, muscle mass (39.75±5.57)kg, lean body mass (41.52±6.79)kg, sitting arm support (49.19±35.28)s, standing timing test (22.13±6.01)s, half crunches (20.12±6.48), grip strength [left (15.98±4.86)kg; right (16.37±5.46)kg], heart rate immediately after 2 min stepping exercise (91.43±13.44)frequency/min, Standing on one foot with eyes closed [left (5.82±5.20)s; right (6.02±5.56)s] compared with before exercise, the body fat decreased(t=2.57,2.72,2.07,2.10,3.31,2.92,2.76,3.44, 2.86,2.04,2.38, -2.92,P<0.05); after the intervention, the sitting arm support and closed eyes standing(right) improved(P<0.05). Conclusion Aerobic combined resistance exercise can improve muscle strength and endurance, aerobic endurance and balance ability in adolescents with moderate mental retardation and adaptability of teenagers with moderate mental retardation.

Objective:To explore the atypical cranial MRI manifestation of patients with Wilson’s disease (WD) .Methods :The clinical features and cranial MRI manifestation of two patients with WD ,who were confirmed with clinical biochemistry and gene diagnosis ,were analyzed .Retrospectively analysis of reported cases was conducted based on review of literatures . Results:The typical WD MRI manifestations were lesions at bilateral lenticular nucleus ,thalamus and midbrain .However , these two cases showed subcortical hypointense on T 1WI ,hyperintense on T2WI ,and Flair hyperintense ,which were rare . According to the literature ,13 WD patients’ cranial MRI showed abnormal signal of subcortical white ,and lesions involved cerebral cortex in 9 of them (9 cases of frontal lobe ,4 cases of parietal lobe ,2 cases of temporal lobe ) .Among these 13 patients ,9 contained extrapyramidal manifestation as bradykinesia ,movement disorder and etc ,6 had intellectual impairment or dementia ,and 9 had epileptic seizure .The high rate of seizure might be related to cortical or subcortical lesions ,which had no special relationship with particular mutation in ATP7B gene .Conclusions :The cranial MRI manifestations of WD patients are variable ,and closely related to clinical symptoms .