Objective To investigate the effect of Tanreqing injection assisted ganciclovir on children with respiratory syncytial virus pneumonia . Methods 145 cases of RSVP pediatric patientsin from February 2013 to January 2016 in our hospital were retrospectively chosen,according to different drug regimen,they were divided into two groups,the contronl group of 71 cases with ganciclovir injection treatment and study group of 74 cases,with Tanreqing injection treatment on the basis of the contronl group.The blood gas analysis was performed on the arterial blood of the two groups before treatment and 7 and 14 days after continuous administration.The changes of blood gas indexes (pH,PaO2,PaCO2) were compared.The lung rales, wheezing, fever, cough, wheeze disappearance of time and side effects of the children were recorded.Results After 7 and 14 days of treatment, the Ph of blood gas parameters in the study group were (7.38 ±0.21) and (7.41 ±0.26), the level of PaO2 were (96.45 ±4.06) mmHg and (98.84 ± 5.27) mmHg,which were significantly higher than those of the control group (P<0.05);the level of PaCO2 in the study group were(45.02 ±4.23) mmHg and (41.26 ±3.16) mmHg, which were significantly lower than those in the contronl group (P<0.05).The rale resorption time in the study group was (4.47 ±1.06) days, the duration of wheezing subsided was (5.03 ±0.43) days, the duration of wheezing was (4.89 ±0.72) days, the duration of fever subsided was (2.46 ±0.32) days, the duration of cough was (8.41 ±1.54) days,were significantly lower than the control group(P<0.05).The adverse reaction rate in the study group was 8.11%, significantly lower than that in the control group 21.13%(P<0.05).Conclusion The combination of Tanreqing injection combined with ganciclovir has a good effect on children with RSVP , and can significantly shorten the time of clinical evidences such as wheezing, wheezing and pulmonary rales, and improve the blood gas level in children,reduce adverse reactions.

Objective To explore the concentration of mannan-binding lectin(MBL ) of patients with chronic hepatitis B virus (HBV) .Methods Serum MBL concentrations of 250 patients(case group) with HBV and 150 healthy controls(control group) were measured .Results The serum MBL concentration in case group was higher than that in control group(t=7 .097 ,P<0 .01) . The serum MBL concentration in high HBV-DNA loading group was higher than that in control group(t=7 .179 ,P<0 .01) .The serum MBL concentration in low HBV-DNA loading group was higher than that in control group(t=4 .404 ,P<0 .01) .Conclusion Detection of serum MBL in patients with HBV will be clinically useful for understanding state of an illness and observing the cur-ative effect .

Objective:To investigate the effect of early enteral nutrition (EN) standardized treatment process management on the ventilation treatment effect and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) on invasive mechanical ventilation.Methods:Forty-three patients with AECOPD on invasive mechanical ventilation admitted to Shenzhen Baoan District People's Hospital from January 2017 to December 2018 were enrolled. According to the start time of the continuous quality improvement project of nutritional support treatment for critically ill patients in the hospital, 20 patients from January 1st to December 31st in 2017 were enrolled in the routine EN group, and 23 patients from January 1st to December 31st in 2018 were enrolled in the early EN group. In the early EN group, when the patient was hemodynamically stable within 24 hours after intensive care unit (ICU) admission and there was no contraindication for EN, early trans nasal intestinal EN was started, and the infusion rate was adjusted or parenteral nutrition was added according to the EN tolerance score. The target feeding amount was 104.6-125.5 kJ·kg -1·d -1, and achieve complete EN. The conventional EN group started EN after patients had experienced the early stress stage, the vital signs were stable, and 48 hours after ICU admission. The management process was the same as the early EN group. The ventilation indicators including rapid shallow breathing index (RSBI), arterial blood pH value, arterial oxygen partial pressure (PaO 2), arterial partial pressure of carbon dioxide (PaCO 2), and base excess (BE) at weaning, PaCO 2, CO 2 retention rate at 2 hours after weaning, as well as critical management indicators including the incidence of ventilator-associated pneumonia (VAP), duration of invasive mechanical ventilation, length of ICU stay, total hospitalization cost and re-intubation rate between the two groups were compared. Results:After the early EN standardized treatment process management, the RSBI at weaning of the patients in the early EN group was significantly lower than that in the conventional EN group (times·min -1·L -1: 36.68±16.12 vs. 52.63±14.81, P < 0.05), but no significant difference in pH value, PaO 2, PaCO 2 or BE was found as compared with the conventional EN group. The PaCO 2 and CO 2 retention rate at 2 hours after weaning in the early EN group were significantly lower than those in the conventional EN group [PaCO 2 (mmHg, 1 mmHg = 0.133 kPa): 52.48±7.62 vs. 58.32±8.43, CO 2 retention rate: (10.25±2.86)% vs. (18.46±3.21)%, both P < 0.05]. Compared with the conventional EN group, the incidence of VAP [8.7% (2/23) vs. 15.0% (3/20)], duration of invasive mechanical ventilation (hours: 52.64±14.81 vs. 53.78±12.75), length of ICU stay (days: 4.92±1.26 vs. 5.24±1.84), total hospitalization costs (thousand Yuan: 20.9±4.8 vs. 21.0±6.9) and re-intubation rate [13.0% (3/23) vs. 20.0% (4/20)] were slightly decreased in the early EN group without statistically significance (all P > 0.05). Conclusion:The management of early EN standardized treatment process for patients with AECOPD on invasive mechanical ventilation may alleviate the respiratory muscle fatigue status, and does not increase the complications.