Objective To evaluate the relationship between chemotherapy after pulmonary resection and the incidence rate of bron-chopleural fistula. Methods 246 patients who received pulmonary resection in our hospital from January 2009 to June 2014 were chosen, and they were divided into the chemotherapy group and the non-chemotherapy group. The 138 patients in the chemotherapy group received chemotherapy one month after resection while the other 108 in the non-chemotherapy group did not. Bronchopleural fistula of the two groups were diagnosed and analyzed in order to evaluate the relationship between chemotherapy after pulmonary resection and incidence rate of bron-chopleural fistula. Results There were 12 cases of bronchopleural fistula in the chemotherapy group with an incidence rate of 8. 70%, while there were 2 cases of bronchopleural fistula in the non-chemotherapy group with an incidence rate of 1. 85%. The difference between the two groups is statistically significant (P<0. 05). Conclusion Chemotherapy after pulmonary resection will increase the incidence rate of bron-chopleural fistula.

BACKGROUND: Evidence from in vitro study indicates that bone marrow stromal cells and undifferentiated mesenchymal cells can different into chondrocytes.OBJECTIVE: To observe the morphological changes of red bone marrow and periosteum allograft and its capability of chondrogenesis after transplantation in rabbits for repair of articular cartilage defects.DESIGN: Randomized controlled experiment with rabbits.SETTING: Department of Human AnatomY, Medical College of Yanbian University.MATERIALS: Fourteen Chinese rabbits of either sex with body mass of (2.15±0.30) kg.METHODS: This experiment was carried out in the Department of Human Anatomy, Medical College of Yanbian University between April 2001 and February 2002. Full thickness articular cartilage defect of 3.0 mm×6.0 mm was produced in the rabbits on the patellar surface of the femur in the 28knee joints, which were then randomized to receive either transplantation with autologous red bone marrow and periosteum graft into the bone defect (20 knees) or no grafts (8 knees). The morphological changes of graft were evaluated 7 days and 2, 4, 8, and 12 weeks after the operation by gross,optical microscopic, and electron microscopic observations with also assistance of image analysis.drocyte area of two groups.RESULTS: In the 12th week after the operation, the morphology, distribution and arrangement of the regenerated tissues were similar to normal cartilage in the knees with graft transplantation, and the regenerated tissues grew to be integrated with the surrounding normal cartilage with obscure boundary between them. But the boundary between the bone defect and surrounding normal cartilage was clearly observed in the ungrafted knees,and most of the defect was replaced by fibroblasts and collagen fibers with only some small chondrocytes seen in the superficial layer. Microscopic observation in the 4th week revealed the presence of chondrocytes in the superficial layer of the graft, and imaging analysis displayed greater single cell surface in the grafted than in the ungrafted knees in the 4th, 8th and 12th weeks [(248.70±16.62) vs (168.23 ±6.14) μm2, (267.79±28.88) vs (172.93±17.18) μm2, (175.75±13.24) vs (145.35±13.54) μm2, P ＜ 0.05].CONCLUSION: The chondrogenesis in autologous complex tissue graft of red bone marrow and periosteum occurs 8 weeks after the operation, and the morphology, distribution and arrangement of the newly generated cells are similar to that of the normal cartilage, with good mutual compatibility and complementarity in the regeneration activity between the two graft tissues.

Objective To investigate the clinical features,therapeutic methods,therapeutic effect and prognosis of a case of bladder urothelial carcinoma patients in combination with trophoblast.Methods The pathological data of a patient with bladder high grade urinary epithelial carcinoma in combination with trophoblast was retrospectively analyzed and the related literatures were reviewed.It was a male patient,69 years old,presenting with total painless gross hematuria.The CT scan showed irregular nodules on the anterior wall of bladder.Results Cystoscopy showed 1.5 cm cauliflower mass on the anterior wall of bladder,and transurethral resection of bladder tumor was performed.The pathology and immunohistochemistry showed urothelial carcinoma.Lung metastases was found due to hemoptysis,and increased serum beta human chorionic gonadotropin (β-HCG) was detected simuhaneously.Pathology was double checked and bladder urothelial carcinoma with trophoblast cell differentiation was considered.Three cycles gemcitabine + cisplatin (GC regimen) and 2 cycles etoposide + methotrexate + vincristine + cyclophosphamide (modified EMA-CO regimen) therapies were given,and the disease was stable at that time.The patient died on June 10,2016,and the total survival period was 9 months.Conclusions The clinical and imaging of urothelial carcinoma with trophoblast differentiation is not special.Diagnosis must depend on the pathological and immunohistochemistry examinations.The efficacy can be evaluated by combining imaging with serumβ-HCG.Treatment should be systemic venous chemotherapy.

Adult ; Androstadienes ; therapeutic use ; Aromatase Inhibitors ; therapeutic use ; Breast Neoplasms ; drug therapy ; Female ; Humans ; Middle Aged ; Nitriles ; therapeutic use ; Triazoles ; therapeutic use

Objective To study perioperative changes in serum levels of TNF-?, IL-6 and IL-10 in orthotopic liver transplantation without veno-venous bypass. Methods Sixteen patients with terminal liver disease underwent orthotopic liver transplantation under general anesthesia. Samples from arterial blood were obtained at beginning of surgery, before the anhepatic phase, 5min before recirculation, 15min and 60min after recirculation, 4h and 24h after operation, respectively. Serum levels of TNF-?, IL-6 and IL-10 were measured by ELISA. Results TNF-? and IL-6 concentrations were kept at a low level before operation, while IL-10 was not detected. The concentrations of IL-6 and IL-10 rose during the anhepatic phase (P

0.05).The 83 samples of HBV genotype B all belonged to subtype Ba,and we had not found subtype Bj.CONCLUSIONS The HBV genotypes among the children carriers of hepatitis B virus in Wenzhou mainly are the genotypes C and B.In two subtypes of genotype B mainly is the subtype Ba.

Family resilience explores the positive resources of a family under adversity. This paper expounded the origin, concept, related factors, framework and implications of family resilience, especially the family resilience in families with a cancer patient.

Objective:To study the clinical application of laparoscopic combined with multi-video debridement in treatment of complicated infectious pancreatic necrosis (CIPN).Methods:The clinical data of 34 patients with CIPN who were treated at the Department of General Surgery, Xuanwu Hospital, Capital Medical University from August 2017 to December 2019 were retrospectively studied. Based on the different video methods used, these patients were divided into 3 groups: the laparoscopic combined with intraoperative ultrasound group, the laparoscopic combined with choledochoscopy group and the laparoscopic group. The number of operations, operation time, blood loss, postoperative complication rates, mortality rates and total length of hospital stay were compared.Results:There were 13 patients in the laparoscopic combined with intraoperative ultrasound group, with age of (56.4±13.4) years. There were 7 patients in the laparoscopic combined with choledochoscopy group, with age of (48.0±8.4) years. There were 14 patients in the laparoscopic group with age of (51.4±15.6) years. The number of operations of the laparoscopic combined with intraoperative ultrasound group, the laparoscopic combined with choledochoscopy group and the laparoscopic group were (2.2±1.1), (1.6±0.8), (2.9±1.4), respectively. The number of operations of the laparoscopic combined with choledochoscopy group were significantly less than that of the laparoscopic group ( P<0.05), but there were no significant differences among the other groups ( P>0.05). The operation time of the laparoscopic combined with intraoperative ultrasound group, the laparoscopic combined with choledochoscopy group and the laparoscopic group were (70.5±22.9) min, (65.7±19.9) min, (51.5±15.4) min, respectively. The operation time of the laparoscopic combined with intraoperative ultrasound group was significantly longer than that of the laparoscopic group ( P<0.05), but there were no significant differences among the other groups ( P>0.05). There were no differences in blood loss, postoperative complication rate, mortality rates and total lengths of hospital stay among the three groups ( P>0.05). Conclusion:Laparoscopic combined with multi-video debridement after making full use of the advantages of each of the video methods, can be used to improve treatment outcomes of patients with CIPN.

Objective To analyze the application and funding for projects in radiation oncology from National Natural Science Foundation of China ( NNSFC ) from 2006 to 2015. Methods To collect the funding information in radiation oncology from NNSFC from 2006 to 2015, a computerized search was performed in the ISIS system using a subject code of H1610 and a keyword of radiation oncology. Analyses were performed in distribution of research fields, the geographical distribution of applicants, and the properties of institutes/universities the applicants were affiliated with. Results In the last decade, a total of 435 projects in the field of radiation oncology were funded with 180 million yuan. Most projects were funded by general, youth, and regional foundation, which covered the highest proportion of NNSFC. For a single project, the amounts of funding from general, youth, and regional foundations were 530, 220, and 400 thousand yuan, respectively. The institutes/universities the NNSFC?funded projects were affiliated with were located quite close to each other. The top 10 institutes/universities in terms of the number of NNSFC?funded projects covered 53% of projects. In all projects, 88% studied basic science, which covered many hot topics in oncology including biological effects of radiotherapy, microenvironment, and stem cells. A small number ( 12%) of projects focused on physics. Top 3 cancers in terms of the number of projects and the amount of funding were lung cancer, nasopharyngeal carcinoma, and esophagus cancer. Conclusions In the last decade, the field of radiation oncology has stable increases in the number of NNSFC?funded projects and the amount of funding. The NNSFC?funded research teams are unevenly distributed, most of which are located in East China. The most popular topic in basic science studies is about biological effects of radiotherapy.

Objective To evaluate the efficacy and safety of cinacalcet on secondary hyperparathyroidism (SHPT) in patients with end-stage renal disease (ESRD). Methods Patients with ESRD and SHPT for the treatment with calcimimetic agents were included in this study. MEDLINE (1996.1-2014.9), OVID (1963.1-2014.9), Chinese Wanfang database (1996.1-2014.9), CNKI (1996.1-2014.9) and the clinical control test database of Cochrane Library were searched . Related literature, including published or unpublished papers, and meeting procedding were hand-searched. Quality assessment and data extraction were conducted by two independent investigators. Meta-analysis was conducted by RevMan 5.2. Results Nineteen randomized controlled trials involving 7 702 patients were included. The meta-analysis showed that compared with conventional therapy,cinacalcet can significantly decrease serum parathyroid hormone in dialysis patients [WMD=-301.54 μg/L, 95%CI:(-344.38)-(-258.7)μg/L, P<0.05], decrease serum level of calcium [WMD=-8.3 mg/L, 95%CI:(-9.1)-(-7.4)mg/L, P<0.05], and decrease serum level of phosphorus [WMD=-3.4 mg/L, 95%CI:(-4.6)-(-2.3) mg/L, P<0.05]. The total incidence of adverse events was similar (RR=1.03, 95%CI:0.98-1.09, P>0.05). Cinacalcet increased nausea (RR =2.05, 95%CI :1.53-2.75, P<0.05), vomiting (RR =2.00, 95%CI:1.78-2.23, P<0.05), diarrhea (RR=1.15, 95%CI:1.03-1.30, P<0.05), and asymptomatic hypocalcaemia (RR=7.60, 95%CI:5.61-10.30, P<0.05), but they were usually transient, and mild to moderate in severity. The mortality was similar (RR=0.97, 95%CI:0.89-1.05, P>0.05). Conclusion Results confirm that cinacalcet suppresses parathyroid hormone and decreases calcium and phosphorus in secondary hyperparathyroidism patients receiving dialysis. Cinacalcet increases risks of nausea, vomiting, diarrhea and hypocalcaemia,without increasing mortality.