Objective: To investigate the therapeutic effect and safety of Jian Shen Li Shui No. 1 for treatment of acute cerebral hemorrhage. Methods: The patients enrolled were randomly devided into 3 groups. The group A were treated with Jian Shen Li Shui No. 1, the group B with Xing Nao Xiao Zhong Capsules and the group C with 20% mannitol. Symptoms and signs, changes of urine volume, quality of life, routine examination of blood, urine and feces, function of liver and kidney, electrocardiogram, blood lipid, sugar, electrolytes, reological changes were observed. Results: The total effective rate in the group A was superior to that in the group B(P0. 05) ; while the cured and markedly effective rate in the group A was better than that in the group C (P