Objective To investigate the ultrasonic performance of carotid atherosclerotic plaque and the correlation between microvessel density in plaque .Methods 87 cases of patients undergoing carotid artery plaque dissection were selected .113 plaques were found .All patients were taken carotid color Doppler sonography test and analysis of the plaque .The maximum thickness of plaques was taken HE stained ,and the vessel density in the plaque was counted .The correlation with sonographic performance of plaques was analyzed .Results The maximum plaque thicknesses in hard plaque ,soft plaque and mixed plaque were (0.49 ±0.05)mm,(0.36 ±0.08)mm and (0.39 ± 0.10)mm,respectively,and cross-sectional area stenosis rates were (88.32 ±6.51)%,(68.92 ±12.05)% and (71.95 ±13.04)%,respectively,the differences were statistically significant (F=16.329,23.723,all P<0.05). The maximum plaque thickness and cross -sectional area stenosis rate in hard plaque were all larger than soft plaque and mixed plaque,the differences were statistically significant (t=7.091 7,2.501 and 6.452,6.086,all P<0.05). The microvessel density values in different plaques were (2.11 ±0.48)strips/mm2,(5.91 ±1.03)strips/mm2 and (3.82 ±0.99)strips/mm2,the differences were statistically significant (F=143.541,P<0.05),soft plaque>mixed plaques>hard plaque,the differences were statistically significant (t=6.579 and 9.392,all P<0.05).Pearson cor-relation analysis showed that the maximum plaque thickness and cross -sectional area stenosis rate in soft plaque were positive correlation between microvascular density values (r=0.372,P=0.011;r=0.438,P=0.000).Conclusion Color Doppler ultrasound examination might indirectly reflect microvessel densities in carotid artery plaque .It could be used preliminary assessment of vulnerability of carotid artery plaque .

Objective To investigate the value of contrast -enhanced ultrasound combined with serum homocysteine in determining the stability of atherosclerotic plaques.Methods 96 cases with cerebrovascular disease accompanied by carotid atherosclerotic plaques were selected.All patients were taken ultrasonography and contrast -enhanced ultrasound.Semi -quantitative grading was used for plaque according to the reinforced.The serum homocys-teine levels were detected.Results A total of 146 plaques of 96 cases were found out.Hard plaques were 13(8.9%),soft plaques were 71(48.6%)and mixed plaques were 62(42.5%).All cases were divided into three groups according to the plaque ultrasound contrast semiquantitative grading.24 cases were in Ⅰ grade group,46 cases were in Ⅱ grade group,26 cases were in Ⅲ grade group.The differences of serum homocysteine levels among the three groups were statistically significant(F =59.942,P <0.05),pairwise compared,the differences were statistically significant(t =16.837,20.682 and 15.416,all P <0.05).Pearson linear correlation analysis showed that contrast -enhanced ultrasound plaque classifications were positively correlated with serum homocysteine levels(r =0.709,P =0.000).Conclusion Contrast -enhanced ultrasound could accurately assess the neovascularization in the plaque. Semi -quantitative grading of ultrasound contrast are positively correlated with serum homocysteine levels.Combined the two could provides scientific basis for early and accurate prediction the stability of plaque.

Objective To explore the effect of modified type B lynch uterine suture combined with calcium in the prevention and treatment for uterine atony postpartum hemorrhage.Methods 63 pregnant women with postpartum hemorrhage risk factors which would be underwent cesarean delivery were randomly divided into the study group (32 cases) and the control group (31 cases).The study group was given intravenous calcium gluconate (10ml) 10 min before the operation,and modified type B lynch uterine suture in the operation.The control group was only given the same dose of oxytocin of the study group.Results The amount of bleeding intraoperation and 24h after the operation was (182.6 ± 47.7) ml and (214.1 ± 63.8) ml,respectively,the time of intraoperative uterine contractions was (3.8 ± 1.3)min,the degree of hemoglobin decreased 24h after the operation was (9.2 ±2.0) min in the study group,which were less than those of the control group(t =7.26,2.97,2.39,4.01,all P ＜ 0.05).There was no statistically significant difference in puerperal morbidity and neonatal asphyxia between the two groups (all P ＞ 0.05).Conclusion The modified type B lynch uterine suture combined with calcium could effectively prevent and treat uterine atony postpartum hemorrhage,and could not increase the rate of neonatal asphyxia and puerperal morbidity.

The present investigation reports the chemical composition of the Rhus typhina L. stem identified via mass spectrometry and NMR as gallic acid, 1-O-galloyl-β-D-glucose, tryptophan, scopolin, methyl gallate, fustin, quercetin, rutin, and 1,2,3,4,6-penta-O-galloyl-β-D-glucose. The antioxidant properties and the chemical composition contents of the R. typhina L. stem grown in different regions in China were de-termined. To determine the antioxidant activity, a total phenolic content analysis, 2, 2-diphenyl-1-pi-crylhydrazyl radical scavenging activity assay, ferric reducing antioxidant power assay, andβ-carotene linoleic acid model system were conducted. The results showed that the Rhus typhina L. stem possessed high antioxidant capacities due to its high phenolic content. The contents of the nine isolated compounds were determined by UPLC-ESI-MS/MS. The calibration curves of the nine isolated compounds were linear within the concentration range and the average recoveries were high. The result showed that 1-O-galloyl-β-D-glucose, gallic acid, methyl gallate, and 1,2,3,4,6-penta-O-galloyl-β-D-glucose could be the compounds mainly responsible for the antioxidant capacity of the R. typhina L. stem. This reveals that the R. typhina L. stem is a good source of antioxidants.

By reviewing the concept of disease management and disease managers, the admission qualification of disease managers, the role and specific work of disease managers in chronic disease management, this paper aims to provide a theoretical basis for disease managers to develop in a deeper and higher direction in chronic disease management, and to further improve the value of nurses themselves and the direction of specialty development.

Objective: To observe the effect of moxibustion on the colonic mucosal barrier of rats with ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). Methods: Forty male Sprague-Dawley rats were randomly divided into a normal group and a modeling group, with 20 rats in each group. Rats in the modeling group were subjected to preparing experimental UC models by drinking 4％ DSS for seven consecutive days. Two modeled rats and two normal rats were randomly selected for model identification. After the success of UC model was confirmed, the remaining 18 modeled rats were randomly divided into three groups, a model group, a model + herbal cake-partitioned moxibustion group, and a model + mild moxibustion group, with six rats in each group; the remaining normal rats were randomly divided into three groups, a normal group, a normal + herbal cake-partitioned moxibustion group, and a normal + mild moxibustion group, with six rats in each group. After 7 d of intervention with the herbal cake-partitioned moxibustion or the mild moxibustion, hematoxylin-eosin (HE) staining technique was used to observe the pathological changes of colon tissue under a light microscope; Western blotting and/or immunohistochemical techniques were used to detect the protein expression levels of Occludin, Claudin, junction adhesion molecular 1 (JAM1), mucin 2 (MUC2), and transforming growth factor beta1 (TGF-β1) in rat colon tissue. Results: Compared with the normal group, the colon tissue was severely damaged, the pathological score was significantly increased, and the protein expression levels of Occludin, Claudin, JAM1, MUC2, and TGF-β1 were significantly decreased in the model group (P<0.01); while there were no significant differences in the colonic histopathological score, protein expression levels of Occludin, Claudin, JAM1, MUC2, and TGF-β1 in the normal + herbal cake-partitioned moxibustion group and the normal + mild moxibustion group (P>0.05). Compared with the model group, the model + herbal cake-partitioned moxibustion group and the model + mild moxibustion group showed repaired colon tissue, ulcer healing, significantly reduced pathological score, and significantly increased protein expression levels of JAM1, MUC2, and TGF-β1 (P<0.05); the Occludin protein expression level in the colon tissue of the model + mild moxibustion group was increased (P<0.01). Conclusion: Neither herbal cake-partitioned moxibustion nor mild moxibustion influences the colonic histopathology and intestinal mucosal barrier-related protein expression in the normal rats; both herbal cake-partitioned moxibustion and mild moxibustion can up-regulate the protein expression levels of JAM1, MUC2, and TGF-β1 in the colon tissue of UC rats. Mild moxibustion can up-regulate Occludin protein expression. This may be a mechanism of moxibustion in reducing colonic mucosa inflammation in UC.