Objective To detect the generation of multidrug -resistant organisms(MDROs)in our burn unit and analyze the antibiotic susceptibility.Methods The specimens were inoculated into different disks to isolate and cultivate bacteria.The antibiotic susceptibility of pathogens isolated was detected and judged by CLSI(clinical and laboratory standards institute)2012.The productive rate of MDROs were detected.Results The detection rate of MRSA and ESBLs were the most,87 (38.3%)and 73 (32.2%)respectively.MRSA was absolutely resistant to penicillin,the drug resistant rates to gentamicin,ciprofloxacin,levofloxacin,tetracycline,and rifampicin were above 70.0%,to erythromycin and clindamycin 52.9%,to moxifloxacin and SMZ -TMP 16.1% and 18.4% respectively, and absolutely sensitive to vancomycin,linezolid and tigecycline.The drug resistant rates of ESBLs to ceftriaxone, aztreonam and gentamicin were above 60.0%,to amoxicillin/clavulanic acid,ceftazidime and tobramycin were about 40.0%,to piperacillin -tazobactam,ertapenem,amikacin and cefoperazone /shubatan were below 20.0%,and absolutely sensitive to imipenem and meropenem.The drug resistant rates of CRE to the familiar antibiotics were above 45.0% except amikacin (18.2%),CR -AB to the common antibiotics were above 80.5% except levofloxacin (25.0%),and MDR/PDR -PA to the familiar antibiotics were above 50.0%.Conclusion The detection and drug resisrance rate of multidrug -resistant organisms in our burn unit was high.The clinic should pay more attention to use antibiotics reasonablely and may combine drugs to treat MDROs.It is necessary to use the antibiotic reasonably within different people to postpone the generation of MDROs.

The effects of fish oil rich in eicosapentaenoic acid (C20:5?-3; EPA) and docosahexaenoic acid (C22:6?-3; DHA) on serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels were investigated in experimental hypercholesterolemic rats. The fish oil contained about 15% EPA and 43% DHA. Each animal was given 1ml fish oil/day by intragastric feeding for 30 days. The results in twice experiments showed that TC concentration in the serum of rats fed fish oil was markedly decreased as compared to rats fed olive oil, but serum HDL-C elevated. Furthermore, the ratio of HDL-C to TC in the serum was also significantly elevated in rats fed fish oil.

Objective To construct and validate a nomogram prognostic model for elderly patients with chronic heart failure(CHF)based on echocardiographic parameters and serological indica-tors.Methods A total of 110 elderly CHF patients admitted to the First Affiliated Hospital of Guizhou University of Chinese Medicine from January 2021 to January 2023 were recruited and randomly divided into a modeling group(80 cases)and a validation group(30 cases).According to the prognosis,the patients in the modeling group were divided into good prognosis subgroup(57 cases)and poor prognosis subgroup(23 cases).Echocardiographic parameters and serological indi-cators were collected to analyze the factors affecting poor prognosis in elderly CHF patients,and then a risk-prediction nomogram model was drawn and verified.Results The patients of poor prognosis had significantly higher values of left ventricular end-diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)and serum levels of soluble growth stimulation ex-pressed gene 2(sST2),N-terminal pro-B-type natriuretic peptide(NT-proBNP)and cardiac tro-ponin T(cTnT),and lower left ventricular ejection fraction(LVEF)value than the good progno-sis group(P＜0.01).Multivariate logistic regression analysis showed that LVEDD,LVESD,LVEF,sST2,NT-proBNP and cTnT were all factors influencing poor prognosis in elderly CHF patients(P＜0.01).The AUC value,sensitivity and specificity of the constructed risk nomogram model based on the above influencing factors were 0.788,83.61％and 80.59％,respectively.Hosmer-Lemeshow test reveal x2=4.115,P=0.894.The results of decision curve analysis(DCA)dis-played that the benefit was higher when the threshold probability ranged from 17％-96％,and the model could select larger range of the threshold probability.Conclusion LVEDD,LVESD,LVEF,sST2,NT-proBNP and cTnT are all associated with poor prognosis in elderly CHF pa-tients.Our risk nomogram model for poor prognosis in elderly CHF patients based on the above factors has good accuracy and discriminability.