Objective To approach the strategies of prevention and treatment of elderly patients with diabetic foot by analyzing the common pathogens and their drug- resistance.Methods136 isolated strains of drug resistance pathogens from 68 elderly patients with infected diabetic foot were retrospectively studied in our hospital from January 2008 to June 2010.Results Bacterial pathogens and fungal pathogens accounted for 92.6％ and 7.4 ％,respectively.The bacterial pathogens included gram-positive bacteria (58.7％) and gram-negative bacilli (41.3％).Among the gram-positive bacteria,staph were most common.Furthermore,the incidence of methicillin resistant staphylococcus aureus (MRSA) and methicillin resistant coagulase negative staphylococcus (MRCNS) increased year by year.Vancomycin-resistant gram-positive bacteria did not appear.Among the gram-negative bacilli,enterobacteriaceae were the most common pathogens.Patients with mixed infections accounted for 61.8％.Fungous infections were all in the form of mixed infection,increasing with years.Conclusions Pathogenic bacteria and its drug resistance should be timely monitored to control and prevent the diabetic foot in the elderly patients.