Objective To evaluate the function of Hybrid capture 2 (HC2) human papillomavirus (HPV) test,liquid-based cytology test (LCT),HPV serial test,LCT serial test and HPV-LCT parallel test for cervical high-grade lesions screening and to guide in selecting the scheme of cervical cancer screening.Methods HPV test,LCT,and colpescopic biopsy were performed in 545 women treated in Centrale Hospital of Klamayi from Sep.2009 and Dec.2011.The pathology results were the final diagnosis to evaluate the value of each approach for screening cervical cancer.Results Of 545 patients, 10 had cervical cancer.41 had cervical intraepithelial neoplasia CIN3,69 had CIN2,and 120 had CIN 1.Positive rate of high risk HPV was 64.22 ％.The sensitivity,specificity,accuracy,positive pre-value,and negative pre-value of HPV test for detecting high-grade cervical lesions were 95.83 ％,84.71％,88.48 ％,30.68 ％,99.12 ％,respectively.The values of LCT were 84.20 ％,89.53 ％,85.53 ％,36.69 ％,91.76 ％,respectively.The values of LCT serial test were 81.03 ％,95.96 ％,78.33 ％,40.69 ％,92.92 ％,respectively.The values of HPV serial test were 81.03 ％,95.26 ％,78.33 ％,42.15 ％,99.52 ％,respectively.The values of HPV-LCT parallel test were 99.20 ％,81.53 ％,90.03 ％,32.09 ％,99.33 ％,respectively.Conclusion HPV-LCT parallel test can significantly improve the detection rate of cervical cancer screening.