MicroRNAs (miRNAs) are another interest of small, non-coding RNAs, which regulate gene expression at post-transcriptional level in a sequence-specific manner. Recent researches demonstrate that miRNAs play important roles in innate immune response at various phases in vertebrates. In order to eliminate pathogens such as virus, miRNAs are crucial molecules in signaling of innate immune, and also in directly interfering in virus replication, therefore, miRNA may work as one important aspect of classical innate immune response against pathogenic microorganism. Meanwhile, pathogenic microorganism, especially viruses, can encode miRNA or regulate the miRNAs expression in host cells to disturb the expression of many immune associated genes directly and/or indirectly, so that they can escape from immune attacking. So, pathogenic microorganism and their hosts might fight with each other at miRNA level immediately after infection in the earliest phase.

Objective To retrospectively analyze the MRI findings of epithelioid angiomyolipoma (EAML) of the liver.Methods The MR findings in a series of 8 patients with pathologically proven liver EAML were retrospectively analyzed. Distribution of lesions, signal intensity characteristics, tumor vascularity,feeding arteries and draining veins, fat, hemorrhage, cystic necrosis and pseudocapsule formation were evaluated and correlated with pathology.Results A single lesion was found in each of the 8 patients.All eight lesions showed long T1,long T2 inhomogeneous signal,and high DWI signal. There was only 1 lesion presented with fat,3 lesions presented with hemorrhage. On the dynamic contrastenhanced MRI scan,all 8 lesions manifested as hypervascular with tortuous vasculature in 7 patients.Dilated feeding arteries and draining veins were seen in 5 patients. Conclusion Liver EAML has unique MR imaging features,exhibiting hyperwascular lesions with dialated,tortuous feeding arteries,and draining veins on DCE MRI,which could be helpful in the differential diagnosis of liver EAML.

RAGE (receptor for advanced glycation end products) is a multiligand receptor on the cell surface.Ligand-RAGE inter-actions activate several signal transduction pathways that propa-gate cellular oxidative stress and inflammatory response.RAGE expressed on the CD4 + T cells has been identified as a central transduction receptor which affects the activation,proliferation, migration and differentiation of the cells.In addition,blockade of RAGE suppressed the development of multiple immune-related
disorders mediated by CD4 + T cells.These studies highlight the importance of RAGE and its ligands for CD4 + T cells.This arti-cle briefly reviews the role of RAGE and its ligands on the prolif-eration,migration and differentiation of CD4 + T cells and sum-marizes the related research progress.