1.CT Diagnosis and Types of Malignant Ovarian Tumor
Hui ZHAO ; Hongyan LIU ; Zhaohu DONG ; Linchuan ZHANG
Journal of Practical Radiology 1992;0(11):-
Objective To improve the CT diagnostic rate of malignant ovarian tumor(MOT).Methods The CT appearences of 42 cases with MOT confirmed by operation and pathology were analyzed retropectively.The CT findings and types,differential diagnosis were emphatically discussed.Results (1)Ovanian tumors were most frequently located in the adnexal and the pouch of Douglas(78.6%);(2)The size of tumors was mostly beyond 5 cm in diameter(95.2%);(3)The most of tumors apperared flower-shaped(71.4%);(4)The tumors were classified as cystic,cyst-solid and solid types,but cyst-solid type was common(61.9%);(5)The solid and solid portion of the mass were enhanced obviously(90.8%);(6)Ascites and invasion of the adjacent organs were common appearences of the metastasis;(7)Arched,small nodelar and nodular calcification in a solid mass or solid portion of mass could be found.Conclusion CT examination is of great value in diagnosis of MOT,which may predict the pathologic characteristics of MOT.
2.Expression of thymidylate synthase and thymidine phosphorylase in gastric cancer and their correlation with prognosis
Dong HUA ; Zhaohu HUANG ; Jianzhong DENG ; Yong MAO
China Oncology 2006;0(10):-
Background and purpose:Chemotherapy plays an important role in the treatment of gastric cancer.It is becoming a direction that the choice of chemotherapeutic agent for the clinic will be based on the levels of some relative gene expressions in the tumor tissue.As the key enzymes of fluoropyrimidines,the expression levels of thymidylate synthase(TS) and thymidine phosphorylase(TP) may correlate with the response of tumor to chemotherapy.This study was to investigate the expression of TS and TP mRNA in gastric cancer tissues and their correlation with prognosis.Methods:The expression levels of TS,TP mRNA in 51 gastric adenocarcinoma tissues were detected by real-time quantitative reverse transcription polymerase chain reaction(RT-PCR).Results:The median expression levels of TS,TP mRNA were 0.94 and 21.20,respectively.There was significant difference in terms of disease-free and overall survival between the gastric cancer patients with high and low TS mRNA expression level(P0.05)but not overall survival(P0.05).Conclusions:The expression levels of TS,TP mRNA may serve as prognostic markers for gastric cancer patients treated with FU-based adjuvant chemotherapy.